Home Metabolism PDE activator Linderane

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Linderane PDE activator

Cat.No.S9229

Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.
Linderane PDE activator Chemical Structure

Chemical Structure

Molecular Weight: 260.29

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Chemical Information, Storage & Stability

Molecular Weight 260.29 Formula

C15H16O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 13476-25-0 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1=CCCC23C(O2)C(C4=C(C1)OC=C4C)OC3=O

Solubility

In vitro
Batch:

DMSO : 52 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
PDE3 [1]
In vitro
Linderane inhibits gluconeogenesis by activating hepatic PDE3 in rat primary hepatocytes. It reduces phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, and decreases intracellular cAMP concentration and CREB phosphorylation in rat primary hepatocytes under both basal and forskolin-stimulated conditions. This compound also increases total PDE and PDE3 activity but not PDE4 activity in rat primary hepatocytes. It indirectly activated PDE3 through extracellular regulated protein kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) activation[1].
In vivo
Linderane improved glucose and lipid metabolism after chronic oral administration in ob/ob mice[1].
References

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