Home PI3K/Akt/mTOR Akt chemical Methyl-Hesperidin

research use only

Methyl-Hesperidin Akt chemical

Cat.No.S2323

Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.
Methyl-Hesperidin Akt chemical Chemical Structure

Chemical Structure

Molecular Weight: 624.59

Jump to

Quality Control

Batch: S232301 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]Insoluble]false Purity: 99.55%
99.55

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (160.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 624.59 Formula

C29H36O15

 Storage (From the date of receipt)
CAS No. 11013-97-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)OC)O)O)O)O)O)O)O

Mechanism of Action

Targets/IC50/Ki
Akt
PKC
In vitro
Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin and methyl hesperidin reduce TNF-alpha-induced VCAM-1 expression through inhibiting the phosphorylation of Akt and PKC. Methyl hesperidin can bind to buman serum albumin (BSA) with binding constants between 18 and 34 mM/L. Long-term carcinogenicity study demonstrates that methyl hesperidin shows no carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map