Guanidinoacetic acid

Catalog No.S6340 Synonyms: Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate

For research use only.

Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate), the natural precursor of creatine, is under investigation as a dietary agent. Guanidinoacetic acid exhibits potential ergogenic benefits for physically active men and women.

Guanidinoacetic acid Chemical Structure

CAS No. 352-97-6

Purity & Quality Control

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Biological Activity

Description Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate), the natural precursor of creatine, is under investigation as a dietary agent. Guanidinoacetic acid exhibits potential ergogenic benefits for physically active men and women.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 117.11
Formula

C3H7N3O2

CAS No. 352-97-6
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04981210 Not yet recruiting -- Pompe Disease National Taiwan University Hospital August 1 2021 --
NCT04174105 Recruiting Genetic: AT845 Pompe Disease (Late-onset) Audentes Therapeutics October 28 2020 Phase 1|Phase 2
NCT04093349 Recruiting Genetic: SPK-3006 Pompe Disease|Pompe Disease (Late-onset)|Glycogen Storage Disease Type 2|Glycogen Storage Disease Type II|LOPD|Lysosomal Storage Diseases|Acid Maltase Deficiency Spark Therapeutics October 1 2020 Phase 1|Phase 2
NCT03893240 Completed Diagnostic Test: Neutralizing Antibody to SPK-3006 capsid Pompe Disease|Pompe Disease (Late-onset)|Glycogen Storage Disease Type 2|LOPD|Lysosomal Storage Diseases|Acid Maltase Deficiency Spark Therapeutics June 12 2019 Not Applicable
NCT03533673 Recruiting Biological: AAV2/8LSPhGAA Pompe Disease Asklepios Biopharmaceutical Inc.|Duke University|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) November 1 2018 Phase 1|Phase 2
NCT04755751 Recruiting Diagnostic Test: Cardiopulmonary exercise testing (CPET) Pompe Disease Infantile-Onset Rambam Health Care Campus June 24 2018 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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