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Baohuoside I ROS chemical

Cat.No.S3840

Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
Baohuoside I ROS chemical Chemical Structure

Chemical Structure

Molecular Weight: 514.52

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Quality Control

Batch: S384001 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (194.35 mM)
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 514.52 Formula

C27H30O10

 Storage (From the date of receipt)
CAS No. 113558-15-9 Download SDF Storage of Stock Solutions

Synonyms Icariside II Smiles CC1C(C(C(C(O1)OC2=C(OC3=C(C(=CC(=C3C2=O)O)O)CC=C(C)C)C4=CC=C(C=C4)OC)O)O)O

Mechanism of Action

In vitro
Baohuoside I accelerates apoptosis through the mitochondrial apoptotic pathway, involving the increment of BAX/Bcl-2 ratio, dissipation of mitochondrial membrane potential, transposition of cytochrome c, caspase 3 and caspase 9 activation, degradation of poly (ADP-ribose) polymerase and the over-production of reactive oxygen species (ROS). In vitro studies with three leukaemia and three solid tumour cell lines show that this compound has cytotoxic properties, with IC50 values of between 2.8 and 7.5 μg/ml.
In vivo
Baohuoside I is both anti-inflammatory and immunosuppressive, but unlike the cytotoxic and anti-rejection drugs it suppresses only B-cell (antibody) and not T-cell responses. This compound may have a role in therapy of those autoimmune diseases.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02931305 Unknown status
Osteoporosis|Cardiovascular Disease
National University Hospital Singapore
 October 2016 Phase 1

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