ER stress & UPR Inhibitor | ER stress & UPR activator | unfolded protein response | endoplasmic reticulum stress | selleckchem.com
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ER stress & UPR

During unstressed conditions, immunoglobulin-heavy-chain-binding protein (BIP) binds to and inhibits the three endoplasmic reticulum (ER)-proximal unfolded-protein response (UPR) transmembrane proteins: activating transcription factor 6 (ATF6), inositol-requiring transmembrane kinase/endonuclease 1 (IRE1) and pancreatic ER kinase (PERK). ER stress is averted as long as newly synthesized proteins fold properly as they transit into the ER lumen through SEC61 channel proteins. When unfolded proteins accumulate during stress (bottom panel), BIP is recruited away from ATF6, IRE1 and PERK. This has the potential to activate the different UPR signalling axes.

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