Manganese chloride

Catalog No.S4827

For research use only.

Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.

Manganese chloride Chemical Structure

CAS No. 7773-01-5

Purity & Quality Control

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Biological Activity

Description Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.
In vitro

MnCl2 inhibits proliferation in a dose- and time-dependent manner, induces G0/G1 and S phase arrest and apoptosis in A549 cells[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: A549 cells
  • Concentrations: 0.1, 0.5, 1.0 or 2.0 mM
  • Incubation Time: 24, 48 or 72 h
  • Method:

    Cells are treated with various concentrations of MnCl2 (0, 0.01, 0.1, 0.5, 1.0 or 2.0 mM) for 24, 48 or 72 h. Cell proliferation is determined with MTT assay and mitotic index measurement and apoptosis is measured by flow cytometer.

  • (Only for Reference)
Animal Research:

[2]

  • Animal Models: 9-10 week old Fischer 344/N rats and FVB/N mice
  • Dosages: 2.0-2.3 mg/m3 at a flow rate of 20 L/min
  • Administration: inhalation exposure
  • (Only for Reference)

Chemical Information

Molecular Weight 125.84
Formula

MnCl2

CAS No. 7773-01-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles [Cl-].[Cl-].[Mn+2]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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