Allantoin

Catalog No.S3856 Synonyms: Glyoxyldiureide, 5-Ureidohydantoin

For research use only.

Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.

Allantoin Chemical Structure

CAS No. 97-59-6

Purity & Quality Control

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Biological Activity

Description Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
In vivo The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increases the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. Allantoin treatment (3 or 10 mg/kg, for 7 days) also increases the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β). Allantoin has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway[2].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: adult male Swiss albino mice
  • Dosages: 20, 40, 60 and 80 mg/kg
  • Administration: p.o.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 7 mg/mL
(44.27 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 158.12
Formula

C4H6N4O3

CAS No. 97-59-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1(C(=O)NC(=O)N1)NC(=O)N

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04325490 Completed Drug: Liquid powder|Drug: Hydrocortisone cream 1% Intertrigo Mahidol University|HOE pharmaceuticals Sdn. Bhd. October 1 2019 Phase 4
NCT04046783 Completed Device: patch Cesarean Section; Dehiscence|Scar Keloid|Wound Heal University of Salerno March 2 2019 --
NCT03849677 Completed Other: Endothelial function and inflammation Healthy|Diet Modification Erasme University Hospital|Fonds National de la Recherche Scientifique|Fonds Erasme|Fonds pour la chirurgie cardiaque March 10 2019 --
NCT03631394 Completed Other: beetroot and anthocyanin|Other: beetroot and placebo Exercise Loma Linda University September 1 2018 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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