Glycochenodeoxycholic acid

Name: Glycochenodeoxycholic acid
Brand: Selleck Chemicals
SKU: S5794
Rating: 5 (1 reviews)

Synonyms: Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate

Catalog No.S5794 Purity: 99.35%

Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid

Glycochenodeoxycholic acid Chemical Structure

CAS: 640-79-9

Selleck's Glycochenodeoxycholic acid has been cited by 1 publication

Purity & Quality Control

Batch: S579401 DMSO] 90 mg/mL] false] Ethanol] 90 mg/mL] false] Water] Insoluble] false Purity: 99.35%

99.35

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Biological Activity

Description	Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid

In vitro
In vitro	Glycochenodeoxycholic acid promotes chemoresistance in HCC cells by down-regulating and up-regulating the expression of apoptotic and anti-apoptotic genes, respectively. Furthermore, Glycochenodeoxycholic acid induces the EMT phenotype and stemness in HCC cells and activated the STAT3 signaling pathway. ^[1]
Cell Research	Cell lines	hepatocellular carcinoma (HCC) cell lines
	Concentrations	200 μM
	Incubation Time	24 h
	Method	HCC cells are treated with Glycochenodeoxycholic acid and chemotherapeuticdrugs5-fluorouracil (5-FU) (120μg/mL) and cisplatin (10 μg/mL), and the cell viability is detected using the CCK-8 assay.

In Vivo
In vivo	Glycochenodeoxycholic acid exerts effects on hypothalamic CRH expression after their uptake through the apical sodium-dependent bile acid transporter and subsequent activation of the glucocorticoid receptor.

References

[1] Shi C, et al. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555.

Chemical Information & Solubility

Molecular Weight	449.62	Formula	C₂₆H₄₃NO₅
CAS No.	640-79-9	SDF	--
Smiles	CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 90 mg/mL ( (200.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 90 mg/mL

Water : Insoluble

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In vivo
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Tech Support

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Handling Instructions

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