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Tea polyphenol

Cat.No.S5104

Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.
Tea polyphenol Chemical Structure

Chemical Structure

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Quality Control

Batch: S510401 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.55%
99.55

Solubility

In vitro
Batch:

DMSO : 100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight Formula Storage (From the date of receipt)
CAS No. 84650-60-2 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Mechanism of Action

In vitro
Tea polyphenols are known as catechins. The catechins are subject to extensive biotransformation including methylation, glucuronidation, sulfation and ring-fission metabolism. (−)-epigallocatechin gallate (EGCG) is the major catechin in tea. Among tea catechins, EGCG is most effective in reacting with most reactive oxygen species.
In vivo
The potential health effects of Tea polyphenols (catechins) depend on the amount consumed and on their bioavailability. Following oral administration to rats, tea catechins are absorbed intestinally. They are rapidly and extensively metabolized in rats.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00176566 Terminated
Oral Leukoplakia
University of Medicine and Dentistry of New Jersey|Rutgers The State University of New Jersey
 September 2003 Phase 2
NCT00176514 Terminated
Mucositis
University of Medicine and Dentistry of New Jersey|Rutgers The State University of New Jersey
 July 2000 Not Applicable

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