Tea polyphenol

Name: Tea polyphenol
Brand: Selleck Chemicals
SKU: S5104
Rating: 5 (1 reviews)

Catalog No.S5104 Purity: 99.55%

Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.

Tea polyphenol Chemical Structure

CAS: 84650-60-2

Selleck's Tea polyphenol has been cited by 1 publication

Purity & Quality Control

Batch: S510401 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.55%

99.55

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Biological Activity

Description	Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.

In vitro
In vitro	Tea polyphenols are known as catechins. The catechins are subject to extensive biotransformation including methylation, glucuronidation, sulfation and ring-fission metabolism. (−)-epigallocatechin gallate (EGCG) is the major catechin in tea. Among tea catechins, EGCG is most effective in reacting with most reactive oxygen species^[1].

In Vivo
In vivo	The potential health effects of Tea polyphenols (catechins) depend on the amount consumed and on their bioavailability. Following oral administration to rats, tea catechins are absorbed intestinally. They are rapidly and extensively metabolized in rats^[1].

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT00176566	Terminated	Oral Leukoplakia	University of Medicine and Dentistry of New Jersey\|Rutgers The State University of New Jersey	September 2003	Phase 2
NCT00176514	Terminated	Mucositis	University of Medicine and Dentistry of New Jersey\|Rutgers The State University of New Jersey	July 2000	Not Applicable

References

[1] Khan N, et al. Life Sci. 2007, 81(7):519-33.

Chemical Information & Solubility

Molecular Weight		Formula
CAS No.	84650-60-2	SDF	Download Tea polyphenol SDF
Smiles	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( ； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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