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Triptolide (PG490)

Name: Triptolide (PG490)
Brand: Selleck Chemicals
SKU: S3604
Rating: 5 (27 reviews)

Catalog No.S3604 Synonyms: NSC 163062

For research use only.

Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

CAS No. 38748-32-2

Selleck's Triptolide (PG490) has been cited by 27 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Related Compound Libraries

Biological Activity

Description

Targets

NF-κB ^[1]
()

HSF1 ^[1]
()

Mdm2 ^[1]
()

In vitro

Triptolide is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. Triptolide is shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. ^[1] Triptolide inhibits the proliferation and colony formation of tumor cells at extremely low concentrations (2–10 ng/mL). Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-κB activation and sensitizing tumor cells for TNF-&alpha induced programmed cell death. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

HT-29	MnfGR5l1d3SxeHnjbZR6KGGpYXnud5Q>			NGe2U3hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyxiSVO1NF0xNjByMkJOwG0>	NGTZXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS3NFg3PCd-MkG0O\|A5PjR:L3G+
HCT116	MUDDfZRwfG:6aXPpeJkh[WejaX7zeC=>			NWrEO3FPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUCuNFA1P87:TR?=	NH;Pc289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyNVU1Pid-M{GxNlE2PDZ:L3G+
SKOV3	NGD5bFVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0		MWK3NkBpenN?	M{XpNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkCwOu69VQ>?	M{iwSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEOzOVQ{Lz5{MEizN\|U1OzxxYU6=
SKOV3	M{XWbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1		NELYSHE4OiCqcoO=	MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0xNjByNt88US=>	MkXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|N{i3NFkoRjJ2M{e4O\|A6RC:jPh?=
SKOV3	NIfPbolEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeC=>		M1W0cFczKGi{cx?=	MYnDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVS1;WN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlAxPzMQvF2=	NUXRR2xjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNVEzOjNpPkK4NFEyOjJ\|PD;hQi=>
KBM5	NXXKZpNOS3m2b4TvfIlkcXS7IHHnZYlve3R?		NXzOcXRjPzJiaILz	MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBqdWG2aX7pZk1z\XOrc4ThcpQhcHWvYX6gT2JOPSClZXzsd{Bp[XKkb4LpcochSmO{LVHicEBVOzF3STDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0xNjByOEROwG0>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2OU[2OUc,OjBzNEm2OlU9N2F-
SKOV3	NFv5[WlEgXSxdH;4bYNqfHliYXfhbY5{fA>?			M4Pu[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KGK7IGPSRkBie3OjeTygTWM2OD1yLkCwPe69VQ>?	NHn4V\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[zO\|g4PCd-MUm2N\|c5PzR:L3G+
MDA-MB-468	MnOwR5l1d3SxeHnjbZR6KGGpYXnud5Q>			M2DkbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODIQvF2=	M{T5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
HCT116	MYPDfZRwfG:6aXPpeJkh[WejaX7zeC=>		MnzCO\|IhcHK\|	M{HtWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODIQvF2=	M{PlU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
SKOV3	M{\3NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1		MV63NkBpenN?	NFSwSpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODIQvF2=	MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4M{e4O\|QoRjF7NkO3PFc1RC:jPh?=
KBM5	MlP1R5l1d3SxeHnjbZR6KGGpYXnud5Q>		MWS3NkBpenN?	M2j2bmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDVTViY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCEY4KtRYJtKGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NE4xOTB\|zszN	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2OU[2OUc,OjBzNEm2OlU9N2F-
Rh30	MVzDfZRwfG:6aXPpeJkh[WejaX7zeC=>		MoTlO\|IhcHK\|	M{\DeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJpOzBiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlAyPM7:TR?=	M{TPPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
A549	NGfUVmRCdnSjZ3;ubZN1KGGldHn2bZR6KGG2			NF;Tc4pCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHj1cYFvKFCDUkKg[ZhxemW\|c3XkJIlvKGi3bXHuJGE2PDliY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kAz\i2OSVfSUG8uVkh{LXnu[JVk\WRiTl\rZZBx[UJiYXP0bZZifGmxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5yMUVOwG0>	NIS1c5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i5OVQ6Oid-MkO4PVU1QTJ:L3G+
SGC7901	Ml76R5l1d3SxeHnjbZR6KGGpYXnud5Q>		NW\UZ3d6PzJiaILz	MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTS2M4QTBzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOTYQvF2=	M4nHPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
MOLT4	M3TvTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1		NFLDWWc4OiCqcoO=	MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNU2xVPCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFE4\|ryP	NVj3[mNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2N\|c5PzRpPkG5OlM4QDd2PD;hQi=>
A549	NVLvN25DS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5Q>		Mmm4O\|IhcHK\|	NXuxdWllS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjBzN{ZOwG0>	NHOzW2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECxNVIzOyd-MkiwNVEzOjN:L3G+
SMMC7721	M4\6eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1		MmrhO\|IhcHK\|	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF6zszN	MmG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4M{e4O\|QoRjF7NkO3PFc1RC:jPh?=
PC3	NXf0WmJyS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5Q>		M3jVdlczKGi{cx?=	MoLTR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUCuNFE5O87:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDBzMUKyN{c,OjhyMUGyNlM9N2F-
MCF7	MkDkR5l1d3SxeHnjbZR6KGGpYXnud5Q>		M1vQXVczKGi{cx?=	MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD6wNVnPxE1?	MoTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4M{e4O\|QoRjF7NkO3PFc1RC:jPh?=
A549	M2Dq[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1			MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyPUCuNFE6\|ryP	MnPtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2N{C4OlQoRjJzNEewPFY1RC:jPh?=
PC3	NXP5[lQ4S3m2b4TvfIlkcXS7IHHnZYlve3R?			MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODMQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ\|N{i3OEc,OTl4M{e4O\|Q9N2F-
Bel7402	MUPDfZRwfG:6aXPpeJkh[WejaX7zeC=>		NF62PZU4OiCqcoO=	NEnxXnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBD\Wx5NECyJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMt88US=>	M3y1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
PC3	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2		MX23NkBpenN?	MkLmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjB{zszN	M2XvfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEOzOVQ{Lz5{MEizN\|U1OzxxYU6=
PC3	MnzVR5l1d3SxeHnjbZR6KGGpYXnud5Q>		M2K0TVczKGi{cx?=	M4HZOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiSVO1NF0xNjB{zszN	MoPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|N{i3NFkoRjJ2M{e4O\|A6RC:jPh?=
PC3	M4HWWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1			MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|Mh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36gZpkhe3WuZn;ybI9l[W2rbnWgRkBie3OjeTygTWM2OD1yLkCy{txO	M1zUNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[3NVU5Lz5{NUS2O\|E2QDxxYU6=
786-O	MkfOR5l1d3SxeHnjbZR6KGGpYXnud5Q>		NFXPR2w4OiCqcoO=	Mnz1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gO\|g3NU9iY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlAzOs7:TR?=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ\|N{i3OEc,OTl4M{e4O\|Q9N2F-
A549	NG\UVGVCdnSjZ3;ubZN1KGGldHn2bZR6KGG2			MV;BcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBCWjJiZYjwdoV{e2WmIHnuJIh2dWGwIFG1OFkh[2WubIOgZ49mgHC{ZYPzbY5oKFSDQ2KxJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gd5Vje3SjbnPlJHAucW6mdXPl[EBKVC16IIDyc4R2[3Srb36gZpkhTUyLU1GsJGlEPTB;MD6wNlPPxE1?	M4P5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEm1OFkzLz5{M{i5OVQ6OjxxYU6=
MDA-MB-231	MlLqR5l1d3SxeHnjbZR6KGGpYXnud5Q>		M2LXWFczKGi{cx?=	M2T5UmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkCyOO69VQ>?	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ\|N{i3OEc,OTl4M{e4O\|Q9N2F-
DU145	MYnDfZRwfG:6aXPpeJkh[WejaX7zeC=>		NGHubWY4OiCqcoO=	M1;KNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjUQvF2=	M3\Z[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
HO8910	MX3DfZRwfG:6aXPpeJkh[WejaX7zeC=>		NFq1bXc4OiCqcoO=	Mon5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTG85QTFyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjkQvF2=	M1GySVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
HCT15	NHTK[FREgXSxdH;4bYNqfHliYXfhbY5{fA>?		NE\ld2s4OiCqcoO=	NIjYT4lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzNTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODJ7zszN	NGP3WHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[zO\|g4PCd-MUm2N\|c5PzR:L3G+
A549	M{nzS2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHu			MYnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyPUCuNFPPxE1?	M3PQSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEG0N\|c1Lz5{OEixOFM4PDxxYU6=
32D	Ml3tR5l1d3SxeHnjbZR6KGGpYXnud5Q>		MWW3NkBpenN?	NFS5fI9EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UA{OkRiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCEY4KtRYJtKGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NE4xOzMQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2OU[2OUc,OjBzNEm2OlU9N2F-
U251	MlXpR5l1d3SxeHnjbZR6KGGpYXnud5Q>			NUO3[pZ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwQVAvODN\|zszN	MmjHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkexOVgoRjJ3NE[3NVU5RC:jPh?=
32D	NVWwflF[S3m2b4TvfIlkcXS7IHHnZYlve3R?		NYrldJFNPzJiaILz	NV7oblRuS3m2b4TvfIlkcXS7IHHnZYlve3RiaX3heIlvcWJvcnXzbZN1[W62IH3veZNmKDN{RDDj[YxteyCqYYLic5JqdmdiQnPyMWFjdCCWM{G1TUBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1yLkCzOO69VQ>?	MkjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEm2OlUoRjJyMUS5OlY2RC:jPh?=
PC3	MX\DfZRwfG:6aXPpeJkh[WejaX7zeC=>		MYW3NkBpenN?	NI\mU5JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA1O87:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ\|N{i3OEc,OTl4M{e4O\|Q9N2F-
KB	MYnDfZRwfG:6aXPpeJkh[WejaX7zeC=>		MoDWO\|IhcHK\|	MmPyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkC0N:69VQ>?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ\|N{i3OEc,OTl4M{e4O\|Q9N2F-
HepG2	MXLDfZRwfG:6aXPpeJkh[WejaX7zeC=>		MoDtOFghcHK\|	M4roV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBZXFRiYYPzZZktKEmFNUC9NE4xPDN\|zszN	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZzM{OzOUc,OzB4MUOzN\|U9N2F-
HeLa	NWjGem1CS3m2b4TvfIlkcXS7IHHnZYlve3R?		NUfpUmo2PzJiaILz	MoDFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFQ4\|ryP	NW[3OYRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2N\|c5PzRpPkG5OlM4QDd2PD;hQi=>
U251	NGrtWlZEgXSxdH;4bYNqfHliYXfhbY5{fA>?		M4n2T\|czKGi{cx?=	NXHlVXN[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODR7zszN	MoH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4M{e4O\|QoRjF7NkO3PFc1RC:jPh?=
K562	M13HdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1		NVLCdYJDPzJiaILz	MmjzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFXPxE1?	M1fVVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
NIH/3T3	NUS5W3oxS3m2b4TvfIlkcXS7IHHnZYlve3R?			M4rVdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9\|VEOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImsJGlEPTB;MD6wOe69VQ>?	NYjmZYtyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlE2PDZpPkOxNVIyPTR4PD;hQi=>
SW1116	NYnxfHcyS3m2b4TvfIlkcXS7IHHnZYlve3R?		MWW3NkBpenN?	NF3X[XpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzFzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjB3Mt88US=>	NWLDVXV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2N\|c5PzRpPkG5OlM4QDd2PD;hQi=>
A549	M1rEXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1		M3e1eFczKGi{cx?=	MmnhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFU6\|ryP	MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4M{e4O\|QoRjF7NkO3PFc1RC:jPh?=
HeLa	MlzMR5l1d3SxeHnjbZR6KGGpYXnud5Q>			NV[yS4J5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkC4O:69VQ>?	NF;2cXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyNVU1Pid-M{GxNlE2PDZ:L3G+
Jurkat	NEDpRZFEgXSxdH;4bYNqfHliYXfhbY5{fA>?			NVLQSGN2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUnW{a3H0JINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUCuNVTPxE1?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{MUW0Okc,OzFzMkG1OFY9N2F-
MKN28	MoX5R5l1d3SxeHnjbZR6KGGpYXnud5Q>		MkHwO\|IhcHK\|	MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT24zQCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNu69VQ>?	M4HEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkO3PFc1Lz5zOU[zO\|g4PDxxYU6=
MDCK	NH\jTYZEgXSxdH;4bYNqfHliYXfhbY5{fA>?			NHTV[o1EgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUGuNu69VQ>?	NEXaSJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyNVU1Pid-M{GxNlE2PDZ:L3G+
Pkd1-/-	MYnJcoR2[3Srb36gc4Y>			MUfJcoR2[3Srb36gc4Yh[2WubDDndo94fGhiYYLy[ZN1KGmwIH3veZNmKFCtZEGtM{0h[2WubIOgbY4heHKnc3XuZ4Uhd2ZiY3HsZ4l2dQ>?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN4MEWzOEc,OTd\|NkC1N\|Q9N2F-
Pkd1-/-	NYTIcXl1UW6lcnXhd4UhcW5?	NF35fI0yODBibl2=	M2HO[lk3KGi{cx?=	NXPKboZkUW6lcnXhd4UhcW5icEKxR2lRN1eDRjDlfJBz\XO\|aX;uJIlvKG2xdYPlJHBs\DFvLz2gZ4VtdHNiYYSgNVAxKG6PIHHmeIVzKDl4IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN4MEWzOEc,OTd\|NkC1N\|Q9N2F-
Pkd1+/-	NXzENYEyUW6lcnXhd4UhcW5?	Mn7LNVAxKG6P		NXLqeVh{UW6lcnXhd4UhcW5iUFOyJIRmeGWwZHXueEBk[WylaYXtJJJmdGWjc3WgbY4hdW:3c3WgVItlOStxLTDj[YxteyCjdDCxNFAhdk1?	Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|NkC1N\|QoRjF5M{[wOVM1RC:jPh?=
Pkd1-/-	M4DtVGlv[3KnYYPlJIlv	NGfuW2EyODBibl2=		MnK4TY5kemWjc3WgbY4hWEN{IHTldIVv\GWwdDDjZYxkcXWvIILlcIVie2ViaX6gcY92e2ViUHvkNU0wNSClZXzsd{BifCBzMECgcm0>	NIHn[\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O2NFU{PCd-MUezOlA2OzR:L3G+
Pkd1-/-	NVLCVG5zUW6lcnXhd4UhcW5?	MY[1NEB2VQ>?		MoPiTY5kemWjc3WgbY4h[2GuY3n1cUBz\WynYYPlJIlvKG2xdYPlJHBs\DFvLz2gZ4VtdHNiYYSgOVAhfU1iaX6gdJJme2WwY3Wgc4YhWnmUIHHueIFod26rc4Sg[IFvfHKxbHXu[S=>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN4MEWzOEc,OTd\|NkC1N\|Q9N2F-
Pkd2+/-	NYjFT4ZST3Kxd4ToJIlvcGmkaYTpc44hd2ZiUFOyJIV5eHKnc4PpcochdW:3c3W=	NXvyfm4xOTByIH7N	M4G5UVI1KGi{cx?=	Mo[2S5Jwf3SqIHnubIljcXSrb36gc4YhWEN{IHX4dJJme3OrbnegcY92e2ViUHvkNkswNSClZXzsd{BieyClZXzsJIRm[XSqIHH0JFExOCCwTTDh[pRmeiB{NDDodpM>	MlfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|NkC1N\|QoRjF5M{[wOVM1RC:jPh?=
KBM5	NFXFSYNEgXSxdH;4bYNqfHliYXfhbY5{fA>?	MnTqNE4xODFidH:gNVchfU1?	MVq3NkBpenN?	MnjnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2JOPSClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEKlcj3BZowh[XRiMD6wNFEhfG9iMUegeW0h[W[2ZYKgO\|IhcHK\|IHL5JG1VWyCjc4PhfS=>	MljBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEm2OlUoRjJyMUS5OlY2RC:jPh?=
KBM5	MUfDfZRwfG:6aXPpeJkh[WejaX7zeC=>	MoTNNE4xODFidH:gNVchfU1?	M3K0cFczKGi{cx?=	NIezc5hEgXSxdH;4bYNqfHliYXfhbY5{fCCrbXH0bY5q[i2{ZYPpd5RidnRiaIXtZY4hU0KPNTDj[YxteyCqYYLic5JqdmdiQnPyMWFjdCCWM{G1TUBufXSjboSgZZQhOC5yMEGgeI8hOTdidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeR?=	M4XKT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUS5OlY2Lz5{MEG0PVY3PTxxYU6=
LNCAP	MV7BcpRi\2:waYP0JIFkfGm4aYT5JIF1	M2SzZVUhfU1?	MUOyOEBpenN?	MnfqRY51[WexbnnzeEBi[3Srdnn0fUBifCCDUjDpckBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyC\|dYDwdoV{e2mxbjDv[kBFUFRvaX7keYNm\CC{ZXPldJRweiC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkh[XRiNTD1UUBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYm=	NEXCUHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5OFc{OSd-Mke5PVQ4OzF:L3G+
LNCAP	Moe2RY51[WexbnnzeEBi[3Srdnn0fUBifA>?	MlXHOVAxKG6P	NH;EU5gzPCCqcoO=	NYrhb2JKSW62YXfvcol{fCCjY4Tpeol1gSCjdDDBVkBqdiCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW\|c3nvckBw\iCGSGStbY5lfWOnZDDy[YNmeHSxcjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliYYSgOVAxKG6PIHHmeIVzKDJ2IHjyd{BjgSCmdXHsJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>?	MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N\|EoRjJ5OUm0O\|MyRC:jPh?=
HepG2	MmXpRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4S=	NWTQU2NsOC5{IH3nM4to	M3vOTFE2KGSjeYO=	NYHaNIhRSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMhgGWwb3fyZYZ1\WRiaX6gRoFt[i:lIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIIT1cY9zKGe{b4f0bEBifCByLkKgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbnPlJIRicWy7IH\vdkAyPSCmYYnz	NXnlR2RpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C2NVM{OzVpPkOwOlE{OzN3PD;hQi=>

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	c-Jun ; MDM2 ; p-AKT / AKT / p-Foxo3a / Foxo3a / p53 ; p-PI3K / PI3K / p85 / p110	22666381 27004407
Growth inhibition assay	Cell viability	22666381

In vivo

Triptolide synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF-α) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction. ^[1] ^[3] Triptolide treatment for 2–3 weeks inhibits the growth of xenografts formed by four different tumor cell lines (B16 melanoma, MDA-435 breast cancer, TSU bladder cancer, and MGC80-3 gastric carcinoma), indicating that TPL has a broad spectrum of activity against tumors that contain both wild-type and mutant forms of p53. In addition, Triptolide inhibits experimental metastasis of B16F10 cells to the lungs and spleens of mice. ^[2] Triptolide has in vitro and in vivo activities against mouse models of polycystic kidney disease. ^[4] LD50: Mice 0.83mg/kg (i.v.). ^[5]

Protocol (from reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	72 mg/mL warmed (199.77 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order (Data is from Selleck tests instead of citations): 2% DMSO+30% PEG 300+2% Tween 80+ddH2O For best results, use promptly after mixing. Click to purchase: PEG300 Tween 80	3mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	360.4
Formula	C₂₀H₂₄O₆
CAS No.	38748-32-2
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C

Download Triptolide (PG490) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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