Home Metabolism P450 (e.g. CYP17) chemical Amentoflavone

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Amentoflavone P450 (e.g. CYP17) chemical

Cat.No.S3833

Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
Amentoflavone P450 (e.g. CYP17) chemical Chemical Structure

Chemical Structure

Molecular Weight: 538.46

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Quality Control

Batch: Purity: 99.94%
99.94

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (185.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 538.46 Formula

C30H18O10

 Storage (From the date of receipt)
CAS No. 1617-53-4 Download SDF Storage of Stock Solutions

Synonyms Didemethyl Ginkgetin Smiles C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

Mechanism of Action

In vitro
Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. It induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. This compound is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells.
In vivo
In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice. This compound can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons.
References

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