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Lycopene

Name: Lycopene
Brand: Selleck Chemicals
SKU: S3943
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S3943

Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant., This compound is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.

Chemical Structure

Molecular Weight: 536.87

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Quality Control

Batch: Purity: 99.28%

99.28

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Solubility

In vitro
Batch:

0.1M NaOH : 5 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	536.87	Formula	C₄₀H₅₆	Storage (From the date of receipt)	3 years -20°C(in the dark) powder
CAS No.	502-65-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vitro	Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization. This compound is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. It has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death.
In vivo	Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of this compound in fruits and vegetables may reduce the likelihood of developing heart disease. It prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. This compound is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats. It acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production.
References	[1] http://www.tandfonline.com/doi/abs/10.1080/07388550091144212 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492052/ [3] https://pubmed.ncbi.nlm.nih.gov/28651168/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04446624	Completed	Breast Cancer\|Depression Anxiety\|Oxidative Stress	Università degli Studi del Piemonte Orientale Amedeo Avogadro	February 1 2018	Not Applicable
NCT03608254	Completed	Vascular Health of Postmenopausal Women	University of Alabama Tuscaloosa	November 5 2015	--

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