Lycopene

Catalog No.S3943 Synonyms: ψ,ψ-Carotene

For research use only.

Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.

Lycopene Chemical Structure

CAS No. 502-65-8

Purity & Quality Control

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Biological Activity

Description Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
In vitro

Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization[3]. Lycopene is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. Lycopene has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43[1]. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death[2].

In vivo Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of lycopene in fruits and vegetables may reduce the likelihood of developing heart disease. Lycopene prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. Lycopene is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats[1]. Lycopene acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production[3].

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: HT-29, T84 and MCF-7 cells
  • Concentrations: 1-5 μM
  • Incubation Time: 48 and 96 h
  • Method:

    Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI.

  • (Only for Reference)
Animal Research:

[3]

  • Animal Models: Male C57BL/6 mice
  • Dosages: 25 or 50 mg/kg/day
  • Administration: by orogastric gavage
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 536.87
Formula

C40H56

CAS No. 502-65-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04446624 Completed Other: Music therapy intervention Breast Cancer|Depression Anxiety|Oxidative Stress Università degli Studi del Piemonte Orientale Amedeo Avogadro February 1 2018 Not Applicable
NCT03608254 Completed Other: 100% watermelon juice Vascular Health of Postmenopausal Women University of Alabama Tuscaloosa November 5 2015 --
NCT01102504 Withdrawn Drug: Placebo|Dietary Supplement: Ateronon Carotid Atherosclerotic Disease Cambridge University Hospitals NHS Foundation Trust August 2015 Not Applicable

(data from https://clinicaltrials.gov, updated on 2021-09-06)

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