Maltol

Catalog No.S4940 Synonyms: Larixinic acid, Palatone, Veltol

For research use only.

Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.

Maltol Chemical Structure

CAS No. 118-71-8

Purity & Quality Control

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Biological Activity

Description Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.
In vitro

Maltol can effectively protect nerve cells against oxidative damage caused by ROS in order to maintain normal physiological functions of cells and inhibit diabetes-induced oxidative stress and irreversible kidney damage[1].

In vivo For hepatoprotective activity in vivo, pretreatment with maltol (12.5, 25 and 50 mg/kg; 15 days) drastically prevents the elevated activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and triglyceride (TG) in serum and the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) in liver tissue. Meanwhile, the levels of hepatic antioxidant, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) are elevated by maltol pretreatment, compared to the alcohol group. Maltol pretreatment significantly inhibits alcohol-induced hepatocyte apoptosis and fatty degeneration. It is effective in the prevention of alcohol-induced hepatic damage in mice[1]. Also, maltol is suggested to be a functional agent to prevent the oxidative damage in the brain of mice[2].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Male ICR mice
  • Dosages: 12.5, 25 and 50 mg/kg
  • Administration: by gastric intubation
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 25 mg/mL
(198.23 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 126.11
Formula

C6H6O3

CAS No. 118-71-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=O)C=CO1)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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