Salicylic acid

For research use only.

Catalog No.S4539 Synonyms: 2-Hydroxybenzoic acid

Salicylic acid Chemical Structure

CAS No. 69-72-7

Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.

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Biological Activity

Description Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
Targets
Ethylene biosynthesis [4] COX [1]
()
In vitro

Salicylic acid (SA) is a phenolic phytohormone involved in plant defence against pathogens. It significantly stimulated PON1 activity in a concentration dependent manner[3].

In vivo Although oral SA (5.5 mg/kg body weight) during the Hg(0) exposure did not reduce the Hg levels in these organs, it effectively counteracted the Hg(0)-induced growth inhibition, and improved the behavioral performance, accompanied by a series of ameliorations in the antioxidative defense and anti-inflammatory response[2].

Protocol

Solubility (25°C)

In vitro DMSO 27 mg/mL (195.48 mM)
Ethanol 27 mg/mL (195.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 138.12
Formula

C7H6O3

CAS No. 69-72-7
Storage powder
in solvent
Synonyms 2-Hydroxybenzoic acid
Smiles C1=CC=C(C(=C1)C(=O)O)O

In vivo Formulation Calculator (Clear solution)

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Dilution Calculator

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The Serial Dilution Calculator Equation

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04811625 Not yet recruiting Drug: PL-ASA Healthy Volunteers PLx Pharma May 2021 Phase 4
NCT04792723 Not yet recruiting Drug: Sublingual aspirin|Drug: Oral aspirin Cardiovascular Diseases Vita Green Health Products Co. Ltd March 5 2021 Phase 1
NCT04645004 Recruiting Drug: Aspirin 81Mg Ec Tab Preeclampsia Thomas Jefferson University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|March of Dimes December 31 2020 Phase 1|Phase 2
NCT04295850 Recruiting Drug: Aspirin 81 mg Preeclampsia Thomas Jefferson University August 21 2020 --
NCT04328883 Completed Drug: Aspirin Platelet Aggregation Inhibitors Inova Health Care Services July 16 2019 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID