research use only

Trigonelline Hydrochloride Bacterial chemical

Name: Trigonelline Hydrochloride
Brand: Selleck Chemicals
SKU: S3802
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S3802

Trigonelline (Nicotinic acid N-methylbetaine, Coffearine, Gynesine), a major alkaloid component of fenugreek, has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and also has been shown to reduce diabetic auditory neuropathy and platelet aggregation.

Chemical Structure

Molecular Weight: 173.6

Jump to

Quality Control

Batch: Purity: 99.99%

99.99

Related Targets	Integrase Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Bacterial Inhibitors	Berberine BTZ043 Racemate Teicoplanin Ornidazole Skatole Berberine Sulfate Pipemidic acid Ceftiofur PBTZ169 Aminothiazole

Solubility

In vitro
Batch:

DMSO : 18 mg/mL (103.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	173.6	Formula	C₇H₈NO₂.Cl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	6138-41-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Nicotinic acid N-methylbetaine Hydrochloride, Coffearine Hydrochloride, Gynesine Hydrochloride			Smiles	C[N+]1=CC=CC(=C1)C(=O)O.[Cl-]

Mechanism of Action

In vitro	Trigonelline suppresses lipid droplet accumulation in a concentration (75 and 100 μM) dependent manner. Treatment of adipocyte with of Trigonelline down-regulates the peroxisome proliferator-activated receptor (PPAR) and CCAAT element binding protein (C/EBP- ) mRNA expression, which leads to further down regulation of other gene such as adiponectin, adipogenin, leptin, resistin andadipocyte fatty acid binding protein (aP2) as compared with respective control cells on 5th and 10thday of differentiation .
In vivo	Trigonelline has been shown to reduce diabetic auditory neuropathy and platelet aggregation. In rabbits, the main parameters for the fenugreek extract (i.g.) are as follows: T_1/2(Ka)=0.9 h, T_1/2(Ke)=2.2 h, V=0.64 L/kg, area under the curve=1.93 mg/min/L. The main parameters for trigonelline (i.v.) are as follows: T_1/2α=10.8 min, T_1/2β=44.0 min, K₂₁=0.044/min, K₁₀=0.026/min, K₁₂=0.017/min, area under the concentration-time curve=931.0 mg/min/L. Trigonelline has a moderate rate of absorption and high rate of elimination in the rabbit. Trigonelline has beneficial effects in several human diseases, notably diabetes and central nervous system disease. Its properties include hypoglycemic, hypolipidemic, improving diabetic auditory neuropathy, neuroprotective, antimigraine, sedative, antibacterial, antiviral, and anti-tumor activities; it also improves memory retention and inhibits platelet aggregation.
References	[1] https://pubmed.ncbi.nlm.nih.gov/22680628/ [2] https://pubmed.ncbi.nlm.nih.gov/24369814/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):