Creatine

Catalog No.S5588 Synonyms: Methylguanidoacetic acid

For research use only.

Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.

Creatine Chemical Structure

CAS No. 57-00-1

Selleck's Creatine has been cited by 2 Publications

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Biological Activity

Description Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
Targets
JAK2 [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

Water 26 mg/mL
(198.27 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 131.13
Formula

C4H9N3O2

CAS No. 57-00-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(CC(=O)O)C(=N)N

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04218786 Suspended Drug: Colchicine|Drug: Placebo oral tablet Myocardium; Injury|Myocardial Infarction|Myocardial Ischemia Shifa Tameer-e-Millat University|Rawalpindi Institute of Cardiology December 2025 Phase 2
NCT05111054 Suspended Other: Resistance Exercise Muscle Damage Durham University January 2023 Not Applicable
NCT04094948 Not yet recruiting Drug: Clenbuterol|Drug: Placebos Pompe Disease (Late-onset) Duke University January 1 2023 Phase 2
NCT05148208 Not yet recruiting Device: Creatine supplementation to dialysate Dialysis; Complications University Medical Center Groningen January 1 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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