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Creatine JAK inhibitor

Cat.No.S5588

Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue. This compound can inhibit the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
Creatine JAK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 131.13

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Quality Control

Batch: S558801 Water]18 mg/mL]true]DMSO]Insoluble]false]]]false Purity: 98%
98

Solubility

In vitro
Batch:

Water : 18 mg/mL (超声加热十分钟，60℃)

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 131.13 Formula

C4H9N3O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 57-00-1 -- Storage of Stock Solutions

Synonyms Methylguanidoacetic acid SMILES CN(CC(=O)O)C(=N)N

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
JAK2
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-10)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07756060 NOT_YET_RECRUITING
Brain Injury; Traumatic Brain Injury; Stroke
Spaulding Rehabilitation Hospital
 2026-10
NCT06018519 RECRUITING
Creatine Transporter Defect
Hospices Civils de Lyon
 2023-03-13
NCT07463092 RECRUITING
Prostate Cancer; Sarcopenia
University of Sao Paulo
 2026-05-01
NCT06112990 RECRUITING
Metastatic Prostate Cancer
University of Utah
 2023-11-09 PHASE3
NCT07729930 RECRUITING
Cognition; Muscle Strength; Fatigue Symptom; Blood Pressure and Augmentation Index; Body Composition Changes; Sleep; Gastrointestinal Comfort; Quality of Life; Joint Pain; Inflammation Biomarkers; Bone Metabolism Biomarkers; Menopause Symptoms
Loughborough University
 2026-05-01
NCT07310043 NOT_YET_RECRUITING
Neurocognitive Disorders; Postoperative Delirium
Massachusetts General Hospital
 2026-09-01

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