Creatine

For research use only.

Catalog No.S5588 Synonyms: Methylguanidoacetic acid

1 publication

Creatine Chemical Structure

CAS No. 57-00-1

Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.

Selleck's Creatine has been cited by 1 publication

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Biological Activity

Description Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
Targets
JAK2 [1]
()

Protocol

Solubility (25°C)

In vitro Water 26 mg/mL (198.27 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 131.13
Formula

C4H9N3O2

CAS No. 57-00-1
Storage powder
in solvent
Synonyms Methylguanidoacetic acid
Smiles CN(CC(=O)O)C(=N)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02463305 Not yet recruiting Drug: Creatine monohydrate|Other: Placebo Colitis Ulcerative University of Colorado Denver January 2022 Early Phase 1
NCT04094948 Not yet recruiting Drug: Clenbuterol|Drug: Placebos Pompe Disease (Late-onset) Duke University January 1 2022 Phase 2
NCT04903496 Not yet recruiting -- Diabetes Boehringer Ingelheim|Chengdu Big Data Association November 9 2021 --
NCT05012982 Not yet recruiting Device: AirBand|Device: uninflated AirBand Anterior Cruciate Ligament Reconstruction Yale University October 2021 Phase 4
NCT04735172 Not yet recruiting Other: specific MRI Acquisition (NMR spectroscopy) at 7T Parkinson''s Disease University Hospital Clermont-Ferrand September 2021 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID