Creatine

Synonyms: Methylguanidoacetic acid

Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.

Creatine Chemical Structure

Creatine Chemical Structure

CAS: 57-00-1

Selleck's Creatine has been cited by 3 publications

Purity & Quality Control

Batch: S558801 Water] 26 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 98%
98

Creatine Related Products

Signaling Pathway

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Biological Activity

Description Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
Targets
JAK2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04218786 Withdrawn
Myocardium; Injury|Myocardial Infarction|Myocardial Ischemia
Shifa Tameer-e-Millat University|Rawalpindi Institute of Cardiology
December 2025 Phase 2
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Takotsubo Cardiomyopathy
University Hospital Heidelberg|German Centre of Cardiovascular Research (DZHK)|Coordinating Centre for Clinical Studies (KKS) Heidelberg
February 2024 Phase 2
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C3 Glomerulopathy
NovelMed Therapeutics
January 2024 Phase 1|Phase 2
NCT06185790 Recruiting
Mitochondrial Diseases|Diabetes-Deafness Syndrome Maternally Transmitted
Radboud University Medical Center|Stichting Stofwisselkracht
January 1 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 131.13 Formula

C4H9N3O2

CAS No. 57-00-1 SDF --
Smiles CN(CC(=O)O)C(=N)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 26 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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