Kynurenic acid

For research use only.

Catalog No.S4719 Synonyms: Quinurenic acid|Kynurenate

1 publication

Kynurenic acid Chemical Structure

Molecular Weight(MW): 189.17

Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.

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Selleck's Kynurenic acid has been cited by 1 publication

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Biological Activity

Description Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.
Targets
α7 nicotinic acetylcholine receptor [1] glutamate receptors [2] NMDAR [4]
In vitro

Kynurenic acid(KYNA) is neuroactive tryptophan metabolites formed along the kynurenine pathway. It is considered a non-competitive antagonist of glutamate receptors of NMDA type. KYNA, at low concentration, inhibits FGF-1 release in all cellular models and displays a major stimulatory effect on the proliferation rate of mouse microglia and human glioblastoma cells, in vitro[2].

In vivo Treatment with KYNA (30–100 mg per kg of body weight, intravenously) 4 h before the start of heat stress significantly (P<0.05) and dose-dependently decreases the survival time to new values of 152–356 min compared with normothermic rats. KYNA protects against hypotension but not hyperthermia during heatstroke. KYNA attenuates hypothalamic neuronal degeneration and apoptosis during heatstroke. Also spleen, kidney, liver, and lung apoptosis during heatstroke are decrease. KYNA up-regulates serum IL-10 levels but down-regulates serum TNF-α and ICAM-1 levels. KYNA treatment significantly prevents the occurrence of heat-induced multi-organ damage and inflammation without affecting the induced hyperthermia. Only high doses of KYNA proved to be neuroprotective in neonatal rats by reducing anoxia or hypoxia-ischemia-induced brain edema and in adult rats and gerbils given before ischemia induction. KYNA cannot cross the blood-brain barrier[3].

Protocol

Animal Research:

[3]

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  • Animal Models: Adult male Sprague-Dawley rats
  • Dosages: 30-100 mg/kg
  • Administration: i.v
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL (52.86 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 189.17
Formula

C10H7NO3

CAS No. 492-27-3
Storage powder
in solvent
Synonyms Quinurenic acid|Kynurenate
Smiles OC(=O)C1=CC(=C2C=CC=CC2=N1)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04013555 Recruiting Drug: N-acetylcysteine (NAC)|Drug: Placebo|Drug: Tryptophan Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder University of Maryland Baltimore January 20 2020 Phase 1|Phase 2
NCT03901859 Recruiting -- Attention Deficit Hyperactivity Disorder National Taiwan University Hospital April 1 2019 --
NCT02234752 Terminated Drug: Galantamine ER|Drug: Memantine XR Schizophrenia|Schizoaffective Disorder Sheppard Pratt Health System September 2014 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID