Catalog No.S4719 Synonyms: Quinurenic acid|Kynurenate
Molecular Weight(MW): 189.17
Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.
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|Description||Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.|
Kynurenic acid(KYNA) is neuroactive tryptophan metabolites formed along the kynurenine pathway. It is considered a non-competitive antagonist of glutamate receptors of NMDA type. KYNA, at low concentration, inhibits FGF-1 release in all cellular models and displays a major stimulatory effect on the proliferation rate of mouse microglia and human glioblastoma cells, in vitro.
|In vivo||Treatment with KYNA (30–100 mg per kg of body weight, intravenously) 4 h before the start of heat stress significantly (P<0.05) and dose-dependently decreases the survival time to new values of 152–356 min compared with normothermic rats. KYNA protects against hypotension but not hyperthermia during heatstroke. KYNA attenuates hypothalamic neuronal degeneration and apoptosis during heatstroke. Also spleen, kidney, liver, and lung apoptosis during heatstroke are decrease. KYNA up-regulates serum IL-10 levels but down-regulates serum TNF-α and ICAM-1 levels. KYNA treatment significantly prevents the occurrence of heat-induced multi-organ damage and inflammation without affecting the induced hyperthermia. Only high doses of KYNA proved to be neuroprotective in neonatal rats by reducing anoxia or hypoxia-ischemia-induced brain edema and in adult rats and gerbils given before ischemia induction. KYNA cannot cross the blood-brain barrier.|
|In vitro||DMSO||10 mg/mL (52.86 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04013555||Not yet recruiting||Drug: N-acetylcysteine (NAC)|Drug: Placebo|Drug: Tryptophan||Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder||University of Maryland Baltimore||October 2019||Phase 1|Phase 2|
|NCT03901859||Recruiting||--||Attention Deficit Hyperactivity Disorder||National Taiwan University Hospital||April 1 2019||--|
|NCT02234752||Terminated||Drug: Galantamine ER|Drug: Memantine XR||Schizophrenia|Schizoaffective Disorder||Sheppard Pratt Health System||September 2014||Phase 2|
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