(-)-Arctigenin

For research use only.

Catalog No.S3897

(-)-Arctigenin Chemical Structure

CAS No. 7770-78-7

(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.

Purity & Quality Control

Biological Activity

Description (-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.
In vitro

Arctigenin induces apoptosis in HT-29 colon cancer cells by regulating ROS and p38 MAPK pathways[1]. It is a phytoestrogen that exerts a proliferative effect by binding to the ER. Treatment with arctigenin effectively downregulates ERα expression. Thus, arctigenin, mainly targets the mTOR pathway in ERα-positive MCF-7 human breast cancer cells, leading to autophagy-induced cell death and the downregulation of ERα expression[2]. Arctigenin decreases BACE1 translation via dephosphorylation of eIF2α, causing the suppression of Aβ production, and initiates autophagy through both AMPK/Raptor signaling activation and AKT/mTOR pathway inhibition, resulting in enhanced Aβ clearance. Arctigenin suppresses BACE1 activity via inhibition of BACE1 translation[3].

In vivo Treatment of arctigenin in mice highly decreases Aβ formation and senile plaques and efficiently ameliorates AD mouse memory impairment of APP/PS1 transgenic model mice[3].

Protocol

Cell Research:[3]
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  • Cell lines: HEK293-APPswe, primary cortical neuronal, and BV2 cells
  • Concentrations: 0.1, 1, 10, 20, 40 μM
  • Incubation Time: 24 h
  • Method: Cells are treated with 0.1% DMSO or different concentrations of arctigenin for 24 h. The cell culture media are collected, and a complete protease inhibitor mixture is added. The culture media are then centrifuged by 20,000 × g at 4°C for 30 min, and supernatants are collected.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: The APP/PS1 mice
  • Dosages: 3 mg/kg/d
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (198.7 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 372.41
Formula

C21H24O6

CAS No. 7770-78-7
Storage powder
in solvent
Synonyms N/A
Smiles COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID