Home Neuronal Signaling Beta Amyloid inhibitor - NF-κB inhibitor Ginsenoside Rg1

research use only

Ginsenoside Rg1 Beta Amyloid inhibitor

Cat.No.S3923

Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. This compound reduces cerebral Aβ levels and NF-κB nuclear translocation.
Ginsenoside Rg1 Beta Amyloid inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 801.01

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Chemical Information, Storage & Stability

Molecular Weight 801.01 Formula

C42H72O14

 Storage (From the date of receipt)
CAS No. 22427-39-0 -- Storage of Stock Solutions

Synonyms Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1 Smiles CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)OC6C(C(C(C(O6)CO)O)O)O)C

Solubility

In vitro
Batch:

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Aβ [5]
NF-κB [6]
In vitro

Ginsenoside Rg1 (Rg1) activates promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promotes the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, this compound induces myotube growth and prevents dexamethasone-induced myotube atrophy. Furthermore, it increases MyoD-dependent myogenic conversion of fibroblast. This chemical enhances glucose uptake in insulin-resistant myoblasts[1]. It possesses the capacity for anti-aging activity in HSCs both in vitro and vivo[2]. This compound promotes endothelial progenitor cells (EPCs) adhesion, proliferation, migration and in vitro vasculogenesis in a dose- and time-dependent manner[3]. It could prevent cellular apoptosis via initiating an autophagic survival response, during which time this chemical could promote the expression of Beclin1 and Bcl-2 and weaken the interaction between Beclin1 and Bcl-2[4].
In vivo

Rg1 can protect BMSCs against senescence and affect cell cycle phase distribution of bone marrow stromal cells (BMSCs) in aged rats. It affects inflammatory cytokine and stem cell factor (SCF) levels of BMSCs. This compound affects inflammatory cytokine and SCF levels of BMSCs. It improves the anti-aging ability of hematopoietic microenvironment through enhancing the anti-oxidant and anti-inflammatory capacities of BMSCs[2]. This chemical has neuroprotective properties in neurodegenerative diseases such as AD. It could ameliorate cognitive impairment in the mouse model of AD, improve the learning and memory abilities, decrease the levels of cerebral Aβ, maintain hippocampal neuron activity, and prevent cellular apoptosis induced by Aβ accumulation. On the other hand, this compound also could protect against brain aging by enhancing the scavenging of free radicals in the brain[5].
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/27228978/
  • [5] https://www.hindawi.com/journals/omcl/2017/6473506/#B16
  • [6] https://pubmed.ncbi.nlm.nih.gov/28903427/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Signaling Pathway Map