2,3-Dihydroxybenzoic acid

Catalog No.S4946 Synonyms: Pyrocatechuic acid, O-Pyrocatechuic acid, 2-Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid

For research use only.

2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.

2,3-Dihydroxybenzoic acid Chemical Structure

CAS No. 303-38-8

Purity & Quality Control

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Biological Activity

Description 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.
In vivo 2,3-dihydroxyhenzoic acid (2,3-DHB) is an orally effective iron-chelating agent in hypertransfused rat. The iron excreted in response tc 2,3-DHB is excreted via the urine. The oral administration of 2,3-DHB decreases time absorption of iron (59FeCl3) by the gut. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: iron-overloaded rat (Sprague-Dawley rats)
  • Dosages: 100 mg/kg
  • Administration: orally
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 30 mg/mL
(194.65 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 154.12
Formula

C7H6O4

CAS No. 303-38-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C(=C1)O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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