Diammonium Glycyrrhizinate

Catalog No.S3622

Diammonium Glycyrrhizinate Chemical Structure

Molecular Weight(MW): 856.99

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.

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Description Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
In vivo Intraperitoneal administration of DG protects mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells is significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 is improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way[1]. DG is able to reduce inflammatory injury via suppression of nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB), tumor necrosis factor‑α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury. DG has neuroprotective potential against ischemia‑reperfusion injury in a model of focal cerebral ischemic‑reperfusion injury[2].

Protocol

Animal Research:[2]
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  • Animal Models: Sprague‑Dawley rats
  • Formulation: Saline
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (116.68 mM)
Water 100 mg/mL (116.68 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 856.99
Formula

C42H62O16. 2H3N

CAS No. 79165-06-3
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04071132 Not yet recruiting -- Post Traumatic Stress Disorder Nadav Goldental|The Chaim Sheba Medical Center August 2019 --
NCT01899833 Recruiting Diagnostic Test: 99mTc-Sestamibi Coronary Artery Disease Cell>Point LLC November 3 2018 Phase 2
NCT03420781 Enrolling by invitation Drug: Relamorelin|Drug: Placebo Gastroparesis|Diabetes Mellitus Allergan January 24 2018 Phase 3
NCT03449628 Recruiting Dietary Supplement: L.casei DG|Dietary Supplement: PLACEBO IBS - Irritable Bowel Syndrome SOFAR S.p.A.|1Med November 6 2017 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID