Molecular Weight(MW): 856.99
Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
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|Description||Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.|
|In vivo||Intraperitoneal administration of DG protects mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells is significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 is improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way. DG is able to reduce inflammatory injury via suppression of nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB), tumor necrosis factor‑α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury. DG has neuroprotective potential against ischemia‑reperfusion injury in a model of focal cerebral ischemic‑reperfusion injury.|
|In vitro||DMSO||100 mg/mL (116.68 mM)|
|Water||100 mg/mL (116.68 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04071132||Not yet recruiting||--||Post Traumatic Stress Disorder||Nadav Goldental|The Chaim Sheba Medical Center||August 2019||--|
|NCT01899833||Recruiting||Diagnostic Test: 99mTc-Sestamibi||Coronary Artery Disease||Cell>Point LLC||November 3 2018||Phase 2|
|NCT03420781||Enrolling by invitation||Drug: Relamorelin|Drug: Placebo||Gastroparesis|Diabetes Mellitus||Allergan||January 24 2018||Phase 3|
|NCT03449628||Recruiting||Dietary Supplement: L.casei DG|Dietary Supplement: PLACEBO||IBS - Irritable Bowel Syndrome||SOFAR S.p.A.|1Med||November 6 2017||Not Applicable|
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