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Procyanidin C1

Synonyms: PCC1

Procyanidin C1 is a polyphenolic component of grape seed extract, increases the healthspan and lifespan of mice through its action on senescent cells. PCC1 is a natural senotherapeutic agent with in vivo activity and a potential intervention to delay, alleviate or prevent age-related pathologies.

Procyanidin C1 Chemical Structure

Procyanidin C1 Chemical Structure

CAS: 37064-30-5

Purity & Quality Control

Batch: Purity: 99.75%
99.75

Procyanidin C1 Related Products

Biological Activity

Description Procyanidin C1 is a polyphenolic component of grape seed extract, increases the healthspan and lifespan of mice through its action on senescent cells. PCC1 is a natural senotherapeutic agent with in vivo activity and a potential intervention to delay, alleviate or prevent age-related pathologies.
In vitro
In vitro

Procyanidin C1 induces DNA damage, cell cycle arrest and enhanced the expression of checkpoint kinases. Procyanidin C1 decreases the level of Bcl-2 but increases the BAX, caspase 3 and 9 expression in cancer cells.[1]
Cell Research Cell lines MDA-MB- 231 cell line, MCF-7 cell line
Concentrations 48 h
Incubation Time 6.25-100 mg/ml
Method

Overnight grown cells (5×103cells/well) are treated for 48 h with procyanidin C1 at a concentration ranging from 6.25 to 100 mg/ml in final volume of 150 ml. Cells without treatment served as control. After treatment, cells are used for MTT assay and cell cycle phase distribution analysis. Analysis of Bcl-2 or BAX levels is performed using an ELISA method.
In Vivo
In vivo

In rodent models, Procyanidin C1 depletes senescent cells in a treatment-damaged tumour microenvironment and enhances therapeutic efficacy when co-administered with chemotherapy. Intermittent administration of Procyanidin C1 to either irradiated, senescent cell-implanted or naturally aged old mice alleviates physical dysfunction and prolongs survival.[2]
Animal Research Animal Models C57BL/6J mice (males, 8–12 weeks)
Dosages 20 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 866.77 Formula

C45H38O18
CAS No. 37064-30-5 SDF --
Storage (From the date of receipt) store at -20℃(in the dark, powder)

In vitro
Batch:

DMSO : 100 mg/mL ( (115.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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