Home Proteases MMP inhibitor - p38 MAPK inhibitor - ERK inhibitor - JNK inhibitor Trans-Zeatin

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Trans-Zeatin MMP inhibitor

Cat.No.S4884

Trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. This compound inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.
Trans-Zeatin MMP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 219.24

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S488401 DMSO]43 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

Chemical Information, Storage & Stability

Molecular Weight 219.24 Formula

C10H13N5O

 Storage (From the date of receipt)
CAS No. 1637-39-4 -- Storage of Stock Solutions

Synonyms (E)-Zeatin Smiles CC(=CCNC1=NC=NC2=C1NC=N2)CO

Solubility

In vitro
Batch:

DMSO : 43 mg/mL ( (196.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
MMP-1 [1]
ERK [1]
JNK [1]
p38 MAPK [1]
In vitro
Pretreatment with trans-Zeatin significantly inhibits UVB-induced MMP-1 expression and c-Jun activation in a dose-dependent manner in cultured human skin fibroblasts, which may be mediated by inhibition of ERK, JNK and p38 MAPKs signaling pathways[1].
References

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