Methyl gallate

Catalog No.S3790 Synonyms: Methylgallate, Gallic acid methyl ester, Gallicin

Methyl gallate Chemical Structure Methyl gallate Chemical Structure

Molecular Weight(MW): 184.15

Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.

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Biological Activity

Description Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
In vitro

Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. The expression of Treg surface markers including CTLA-4, CCR4, CXCR4, and glucocorticoid-induced TNFR are significantly suppressed upon methyl gallate treatment[2].

In vivo In tumor-bearing hosts, methyl gallate treatment substantially reduces tumor growth and prolonged the survival rate. In contrast, nu/nu mice do not show decreased tumor progression in response to methyl gallate. In addition, in tumor-bearing Treg-depleted mice, tumor growth and the survival rates are not changed by methyl gallate treatment, strongly suggesting that the main therapeutic target of methyl gallate in tumor suppression is related to modulation of the CD4+CD25+ Treg cell functions. In the spleen of tumor-bearing mice, methyl gallate treatment induces a significant decrease in the CD4+CD25+Foxp3high Treg cell population. Especially, the number of tumor-infiltrating CD25+Foxp3high Treg cells is significantly lower in methyl gallate-treated mice. methyl gallate can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy[2].

Protocol

Cell Research:[1]
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  • Cell lines: HUVEC
  • Concentrations: 0-0.5 mM
  • Incubation Time: 1 h
  • Method: HUVECs are grown in 96-well micro plates in a final volume of 100 μl culture medium containing 104 cells per well. After allowing the cultures to grow to confluence, chemical and H2O2 treatments are followed with certain intervals. To determine the cell viability, XTT assay kit is used. Two cases of oxidative stress are applied to pre-incubated HUVECs with chemical for 1 h: the treatment with 1 mM H2O2 for 1 h and the treatment with 0.1 mM H2O2 for 48 h. Concentrations of chemical are varied from 0 to 0.5 mM.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: C57BL/6, Foxp3EGFPC57BL/6 or nu/nu mice
  • Formulation: saline
  • Dosages: 200 μg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 36 mg/mL (195.49 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 184.15
Formula

C8H8O5

CAS No. 99-24-1
Storage powder
in solvent
Synonyms Methylgallate, Gallic acid methyl ester, Gallicin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID