Bioactive Compound Library-I

Catalog No.L1700

Offered in 96 or 384 well plate format

A unique collection of 7120 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).

Size

Price

Pre-dissolved In DMSO or Water
100uL/well (2mM or 10mM solution)	USD 64661
2x100uL/well (2mM or 10mM solution)	USD 99147

Selleck USA Tel: (832) 582-8158 [email protected]

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

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Bioactive Compound Library-I Contents

Download the Bioactive Compound Library-I - XLSX

Download the Bioactive Compound Library-I - SDF

Download the Compound Library Usage Instructions-pdf

Cited by 109 Publications

Cell Metab,2020,31(3):564-579

PubMed: 32130883 ( click the link to review the publication )

Cell,2019,7;176(4):687-701.e5.

PubMed: 30735632 ( click the link to review the publication )

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nat Med,2017,23(4):405-408

PubMed: 28388612 ( click the link to review the publication )

Physiol Rev,2017,1;97(3):889-938.

PubMed: 28468832 ( click the link to review the publication )

Cancer Cell,2016,29(6):874-888

PubMed: 27300436 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

EMBO Mol Med,2020,12(3):e10419

PubMed: 31950591 ( click the link to review the publication )

Cancer Res,2020,1;80(7):1387-1400.

PubMed: 32005716 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Int J Cancer,2020,10.1002/ijc.32966

PubMed: 32159854 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )

Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

ACS Infect Dis,2020,10.1021/acsinfecdis.9b00406

PubMed: 31887254 ( click the link to review the publication )

Front Oncol,2020,10:117

PubMed: 32117764 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )
Sci Rep,2020,10(1):2132

PubMed: 32034254 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

Biol Reprod,2020,25;ioaa062.

PubMed: 32463099 ( click the link to review the publication )

Bioorg Med Chem,2020,28(7):115372

PubMed: 32088124 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

Biochem Biophys Res Commun,2020,521(1):232-237

PubMed: 31653348 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.04.20.051581

PubMed: no ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

J Clin Invest,2019,129(10):4377-4392

PubMed: 31498151 ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

J Clin Invest,2019,1;129(3):1129-1151.

PubMed: 30741721 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2019,116(41):20760-20769

PubMed: 31548371 ( click the link to review the publication )

Cell Rep,2019,28(12):3224-3237

PubMed: 31533043 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

J Virol,2019,28;93(18):e00758-19.

PubMed: 31270223 ( click the link to review the publication )
Antiviral Res,2019,163:156-178

PubMed: 30597183 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

RSC Adv,2019,1696-1704

PubMed: 无 ( click the link to review the publication )

Vet Parasitol,2019,265:15-18

PubMed: 30638515 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

NPJ Aging Mech Dis,2019,16;5:2.

PubMed: 30675378 ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cell Chem Biol,2018,25(2):175-184

PubMed: 29249695 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):14017

PubMed: 30228302 ( click the link to review the publication )

Sci Rep,2018,30;8(1):11413.

PubMed: 30061704 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )
J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Invest New Drugs,2018,36(4):590-600

PubMed: 29297149 ( click the link to review the publication )

Mol Immunol,2018,101:86-91

PubMed: 29909366 ( click the link to review the publication )

Trends Microbiol,2018,10.1016/j.tim.2018.04.004

PubMed: 29759926 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )

Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Dis Model Mech,2017,10(9):1155-1164

PubMed: 28754836 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

Transl Oncol,2017,10(4):546-554

PubMed: 28654818 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

Chem Biol Drug Des,2017,90(4):629-636.

PubMed: 28303669 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Comb Chem High Throughput Screen,2016,19(2):161-9.

PubMed: 26552436 ( click the link to review the publication )

Synth Syst Biotechnol,2016,26;1(2):95-108.

PubMed: 29062932 ( click the link to review the publication )

Sci Rep,2016,6:33427

PubMed: 27641902 ( click the link to review the publication )

Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )
Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

J Biomol Screen,2015,20(9):1171-7

PubMed: 26160833 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )

Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

• A unique collection of 7120 bioactive compounds for high throughput screening (HTS) and high content screening (HCS)
• Bioactivity and safety of some compounds confirmed by preclinical research and clinical trials
• Some compounds have been approved by the FDA
• Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure and customer reviews
• NMR and HPLC validated to ensure high purity

Product Details

Formulation:	6618 compounds pre-dissolved in 10mM DMSO, 332 compounds pre-dissolved in 10mM water, 151 compounds pre-dissolved in 2mM DMSO and 19 compounds pre-dissolved in 2mM water
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice
Packaging:	Inert gas

Bioactive Compound Library-I Composition

HTS Facility Partners

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541 small collections of human endogenous metabolites, involving multiple metabolic pathways, which can be used for high-throughput screening, opening up new ways for humans to treat various diseases such as tumors.
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Anti-cancer Compound Library (Verified by Broad Institute)

A unique collection of 922 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
Anti-cancer Metabolism Compound Library

A unique collection of 194 small molecules for cancer metabolism research.
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A unique collection of 700 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
Anti-diabetic Compound Library

A unique collection of 150 small molecules for exploring the development of diabetes.
Anti-infection Compound Library

A unique collection of 927 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc.
Antioxidant Compound Library

A unique collection of 426 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
Anti-parasitic Compound Library

A unique collection of 171 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS).
Antiviral Compound Library

A unique collection of 347 antiviral compounds used for exploring novel antiviral drug.
Apoptosis Compound Library

A unique collection of 978 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
Autophagy Compound Library

A unique collection of 998 small molecules with autophagy-inducing or autophagy-inhibiting activity.
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A unique collection of 247 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS).
Cell Cycle compound library

A unique collection of 120 small molecule compounds used for cell cycle and related diseases research.
CNS-Penetrant Compound Library

A unique collection of 307 CNS-Penetrant compounds with biological activity for neurologic research.
Covalent Inhibitor Library

A unique collection of 81 covalent Inhibitors for high throughput screening (HTS) and high content screening (HCS).
Cytoskeletal Signaling Pathway Compound Library

A unique collection of 184 compounds used for research in cytoskeleton and cytoskeletal interactions.
DNA Damage/DNA Repair compound Library

A unique collection of 511 small molecules used for DNA Damage and Repair research with targeting PARP,ATM/ATR,Topoisomerase,DNA/RNA Synthesis etc.
Drug-like Compound Library

A unique collection of 2081 drug-like compounds used for high throughput screening(HTS) and high content screening(HCS).
Endoplasmic Reticulum Stress Compound Library

A unique collection of 93 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening(HTS) and high content screening(HCS).
Epigenetics Compound Library

A unique collection of 606 compounds with biological activity used for epigenetic research and associated assays.
FDA-approved Anticancer Drug Library

A unique collection of 1567 approved drugs with anticancer activity used for high throughput screening(HTS) and high content screening(HCS).
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A unique collection of 547 compounds used for exploring the mechanism of ferroptosis which is an iron-dependent form of non-apoptotic cell death.
Flavonoid Compound Library

A unique collection of 185 flavonoid compounds used for high throughput screening(HTS) and high content screening(HCS).
Fragment Library

A unique collection of 1015 Fragment compounds for Fragment-Based Drug Discovery (FBDD).
Glutamine Metabolism Compound Library

A unique collection of 236 glutamine metabolism related compounds used for high throughput screening (HTS) and high content screening (HCS).
GPCR Compound Library

A unique collection of 1086 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS).
Gut Microbial Metabolite Library

A unique collection of 91 gut microbial metabolites used for high throughput screening(HTS) and high content screening(HCS).
HIF-1 Signaling Pathway Compound Library

A unique collection of 447 HIF-1 signaling pathway compounds used for oxygen sensing related research.
Highly Selective Inhibitor Library

A unique collection of 339 validated highly selective inhibitors with covering over 123 targets.
Histone modification compound library

A unique collection of 199 small molecule compounds with biological activity used for histone modification research and associated assays.
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Immunology/Inflammation Compound Library

A unique collection of 1834 small molecules with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 3456 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 231 small molecule modulators used for Ion channel research.
JAK/STAT compound library

A unique collection of 50 small molecules used for research in JAK-STAT signaling pathway.
Macrocyclic Compound Library

A unique collection of 106 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
MAPK Inhibitor Library

A unique collection of 175 small molecule inhibitors used for MAPK signaling research.
Medicine Food Homology Compound Library

A unique collection of 376 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
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A unique collection of 2024 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
Methylation Compound Library

A unique collection of 112 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
Natural Organic Compound Library

A unique collection of 1127 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
Neuronal Signaling Compound Library

A unique collection of 1093 small molecule compounds with biological activity used for neurologic research and associated assays
NF-κB Signaling Compound Library

A unique collection of 310 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
Nucleoside Analogue Library

A unique collection of 135 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
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Protease Inhibitor Library

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Protein-protein Interaction Inhibitor Library

A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).
Pyroptosis Compound Library

A unique collection of 441 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
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