Bioactive Compound Library-I

Catalog No.L1700

Offered in 96 or 384 well plate format

A unique collection of 6988 bioactive compounds for high throughput screening (HTS) and high content screening (HCS).

Size

Price

Pre-dissolved In DMSO or Water
100uL/well (2mM or 10mM solution)	USD 63462
2x100uL/well (2mM or 10mM solution)	USD 97309

Selleck USA Tel: (832) 582-8158 [email protected]

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Bioactive Compound Library-I Contents

Download the Bioactive Compound Library-I - SDF

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Cited by 71 Publications

Cell Metab,2020,31(3):564-579

PubMed: 32130883 ( click the link to review the publication )

Nat Med,2017,23(4):405-408

PubMed: 28388612 ( click the link to review the publication )

Cancer Cell,2016,29(6):874-888

PubMed: 27300436 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

EMBO Mol Med,2020,12(3):e10419

PubMed: 31950591 ( click the link to review the publication )

Int J Cancer,2020,10.1002/ijc.32966

PubMed: 32159854 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

ACS Infect Dis,2020,10.1021/acsinfecdis.9b00406

PubMed: 31887254 ( click the link to review the publication )

Front Oncol,2020,10:117

PubMed: 32117764 ( click the link to review the publication )

Sci Rep,2020,10(1):2132

PubMed: 32034254 ( click the link to review the publication )

Bioorg Med Chem,2020,28(7):115372

PubMed: 32088124 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

Biochem Biophys Res Commun,2020,521(1):232-237

PubMed: 31653348 ( click the link to review the publication )

J Clin Invest,2019,129(10):4377-4392

PubMed: 31498151 ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2019,116(41):20760-20769

PubMed: 31548371 ( click the link to review the publication )

Cell Rep,2019,28(12):3224-3237

PubMed: 31533043 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

Antiviral Res,2019,163:156-178

PubMed: 30597183 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )
Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

RSC Adv,2019,1696-1704

PubMed: 无 ( click the link to review the publication )

Vet Parasitol,2019,265:15-18

PubMed: 30638515 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

bioRxiv,2019,http://dx.doi.org/10.1101/665505

PubMed: no ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

Cell Chem Biol,2018,25(2):175-184

PubMed: 29249695 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):14017

PubMed: 30228302 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Invest New Drugs,2018,36(4):590-600

PubMed: 29297149 ( click the link to review the publication )

Mol Immunol,2018,101:86-91

PubMed: 29909366 ( click the link to review the publication )

Trends Microbiol,2018,10.1016/j.tim.2018.04.004

PubMed: 29759926 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Dis Model Mech,2017,10(9):1155-1164

PubMed: 28754836 ( click the link to review the publication )
Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

Transl Oncol,2017,10(4):546-554

PubMed: 28654818 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Sci Rep,2016,6:33427

PubMed: 27641902 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

J Biomol Screen,2015,20(9):1171-7

PubMed: 26160833 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

• A unique collection of 6988 bioactive compounds for high throughput screening (HTS) and high content screening (HCS)
• Bioactivity and safety of some compounds confirmed by preclinical research and clinical trials
• Some compounds have been approved by the FDA
• Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure and customer reviews
• NMR and HPLC validated to ensure high purity

Product Details

Formulation:	6492 compounds pre-dissolved in 10mM DMSO, 327 compounds pre-dissolved in 10mM water, 149 compounds pre-dissolved in 2mM DMSO and 20 compounds pre-dissolved in 2mM water
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice
Packaging:	Inert gas

Bioactive Compound Library-I Composition

HTS Facility Partners

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A unique collection of 2701 approved drugs for high throughput screening (HTS) and high content screening (HCS).
FDA-approved & Passed Phase I Drug Library

A unique collection of 3003 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS).
Preclinical/Clinical Compound Library

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Bioactive Compound Library-Ⅱ

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Kinase Inhibitor Library

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Express-Pick Library

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A unique collection of 2230 natural products for high throughput screening (HTS) and high content screening (HCS).
Human Endogenous Metabolite Compound Library

541 small collections of human endogenous metabolites, involving multiple metabolic pathways, which can be used for high-throughput screening, opening up new ways for humans to treat various diseases such as tumors.
Alkaloid Compound Library

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A unique collection of 236 small molecules used for angiogenesis research targeting Bcr-Abl,BTK,HIF,VEGFR,FGFR,FAK,etc.
Anti-Aging Compound Library

A unique collection of 1503 anti-aging compounds used for aging related research.
Anti-alzheimer Disease Compound Library

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Antibiotics compound Library

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Anti-cancer Compound Library

A unique collection of 3561 anti-cancer compounds for multiple cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc.
Anti-cancer Compound Library (Verified by Broad Institute)

A unique collection of 923 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
Anti-cancer Metabolism Compound Library

A unique collection of 195 small molecules for cancer metabolism research.
Anti-Cardiovascular Disease Compound Library

A unique collection of 702 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
Anti-diabetic Compound Library

A unique collection of 152 small molecules for exploring the development of diabetes.
Anti-infection Compound Library

A unique collection of 930 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc.
Antioxidant Compound Library

A unique collection of 428 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
Antiviral Compound Library

A unique collection of 348 antiviral compounds used for exploring novel antiviral drug.
Apoptosis Compound Library

A unique collection of 693 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
Autophagy Compound Library

A unique collection of 822 small molecules with autophagy-inducing or autophagy-inhibiting activity.
Cambridge Cancer Compound Library

A unique collection of 247 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS).
Cell Cycle compound library

A unique collection of 120 small molecule compounds used for cell cycle and related diseases research.
CNS-Penetrant Compound Library

A unique collection of 307 CNS-Penetrant compounds with biological activity for neurologic research.
Covalent Inhibitor Library

A unique collection of 81 covalent Inhibitors for high throughput screening (HTS) and high content screening (HCS).
Cytoskeletal Signaling Pathway Compound Library

A unique collection of 185 compounds used for research in cytoskeleton and cytoskeletal interactions.
DNA Damage/DNA Repair compound Library

A unique collection of 511 small molecules used for DNA Damage and Repair research with targeting PARP,ATM/ATR,Topoisomerase,DNA/RNA Synthesis etc.
Drug-like Compound Library

A unique collection of 2088 drug-like compounds used for high throughput screening(HTS) and high content screening(HCS).
Epigenetics Compound Library

A unique collection of 580 compounds with biological activity used for epigenetic research and associated assays.
Ferroptosis Compound Library

A unique collection of 549 compounds used for exploring the mechanism of ferroptosis which is an iron-dependent form of non-apoptotic cell death.
Flavonoid Compound Library

A unique collection of 186 flavonoid compounds used for high throughput screening(HTS) and high content screening(HCS).
Fragment Library

A unique collection of 1015 Fragment compounds for Fragment-Based Drug Discovery (FBDD).
Glutamine Metabolism Compound Library

A unique collection of 237 glutamine metabolism related compounds used for high throughput screening (HTS) and high content screening (HCS).
GPCR Compound Library

A unique collection of 1032 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS).
HIF-1 Signaling Pathway Compound Library

A unique collection of 449 HIF-1 signaling pathway compounds used for oxygen sensing related research.
Highly Selective Inhibitor Library

A unique collection of 339 validated highly selective inhibitors with covering over 123 targets.
Histone modification compound library

A unique collection of 200 small molecule compounds with biological activity used for histone modification research and associated assays.
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Immunology/Inflammation Compound Library

A unique collection of 1838 small molecules with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 3470 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 232 small molecule modulators used for Ion channel research.
JAK/STAT compound library

A unique collection of 50 small molecules used for research in JAK-STAT signaling pathway.
Macrocyclic Compound Library

A unique collection of 106 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
MAPK Inhibitor Library

A unique collection of 175 small molecule inhibitors used for MAPK signaling research.
Medicine Food Homology Compound Library

A unique collection of 377 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
Metabolism Compound Library

A unique collection of 2029 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
Methylation Compound Library

A unique collection of 113 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
Natural Organic Compound Library

A unique collection of 1130 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
Neuronal Signaling Compound Library

A unique collection of 1095 small molecule compounds with biological activity used for neurologic research and associated assays
NF-κB Signaling Compound Library

A unique collection of 310 small molecules used for NF-κB Signaling pathway research which plays a key role in immunology/inflammation and cancer.
Nucleoside Analogue Library

A unique collection of 135 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
Obesity Compound Library

A unique collection of 941 compounds used for research in obesity.
PI3K/Akt Inhibitor Library

A unique collection of 262 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.
Protease Inhibitor Library

A unique collection of 227 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).
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A unique collection of 441 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
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A unique collection of 151 small molecules for Ubiquitination related research.

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