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Vanillyl Alcohol

Name: Vanillyl Alcohol
Brand: Selleck Chemicals
SKU: S3859
Rating: 5 (1 reviews)

Synonyms: 4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol, 4-Hydroxy-3-methoxybenzenemethanol

Catalog No.S3859 Purity: 99.75%

Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food.

Vanillyl Alcohol Chemical Structure

CAS: 498-00-0

Purity & Quality Control

Batch: S385901 DMSO] 30 mg/mL] false] ] ] false] ] ] false Purity: 99.75%

99.75

Vanillyl Alcohol Related Products

Biological Activity

Description	Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food.

In vitro
In vitro	Vanillyl alcohol (VA) attenuates the elevation of reactive oxygen species (ROS) levels, decreases in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. It protects dopaminergic MN9D cells against MPP+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process^[2]. VA has a suppressive effect on ferric chloride-induced lipid peroxidation in rat brains in vitro^[3].
Cell Research	Cell lines	MN9D Cells
	Concentrations	1, 10, 20 μM
	Incubation Time	4 h
	Method	MN9D cells are pretreated with various concentrations (10, 100, 200 μg/mL) of GE and 1, 10, 20 μM vanillyl alcohol for 4 h before incubation in medium containing 25 μM MPP+. The control cells are treated with the same medium without drugs.

In Vivo
In vivo	vanillyl alcohol possesses anti-angiogenic, anti-inflammatory, and anti-nociceptive activities. Vanillyl alcohol contains both anticonvulsive and suppressive effects on seizures and lipid peroxidation induced by ferric chloride in rats^[1].
Animal Research	Animal Models	Male ICR mice
	Dosages	3, 10, or 30 mg/kg
	Administration	oral

References

Chemical Information & Solubility

Molecular Weight	154.16	Formula	C₈H₁₀O₃
CAS No.	498-00-0	SDF	--
Smiles	COC1=C(C=CC(=C1)CO)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 30 mg/mL ( (194.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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