Pyrithioxin

Catalog No.S5141 Synonyms: Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide

For research use only.

Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

Pyrithioxin Chemical Structure

CAS No. 1098-97-1

Purity & Quality Control

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Biological Activity

Description Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.
In vivo In old rats, chronic administration of pyritinol increases sensitivity to foot shock and spatial retention. It enhances passive avoidance retention in young and old animals. Acute administration of the drug to young rats reveals a dose-dependent increase in levels of adenosinetriphosphate (ATP) in blood and enhances the age-related decreased utilisation of glucose in various regions of the brain. Chronic treatment with pyritinol elevates the high-affinity uptake of choline in hippocampal and striatal synaptosomes, which is reduced by ageing[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: female NMRI mice
  • Dosages: 200 mg/kg
  • Administration: p.o.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 60 mg/mL
(162.83 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 368.47
Formula

C16H20N2O4S2

CAS No. 1098-97-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=NC=C(C(=C1O)CO)CSSCC2=CN=C(C(=C2CO)O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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