Name: Cordycepin
Brand: Selleck Chemicals
SKU: S3610
Availability: InStock
Rating: 5 (2 reviews)

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Quality Control

Batch: Purity: 99.97%

99.97

Related Targets	HDAC Caspase Proteasome Secretase HCV Protease Cysteine Protease DPP Tyrosinase HIV Protease Serine Protease
Other MMP Inhibitors	Ilomastat (GM6001) Marimastat (BB-2516) Batimastat (BB-94) SB-3CT T-5224 Nobiletin NSC 405020 MMP-9-IN-1 JNJ0966 1, 10-Phenanthroline monohydrate

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 25 mg/mL

Ethanol : 1 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.500mg/ml (9.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.500mg/ml (9.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	251.24	Formula	C₁₀H₁₃N₅O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	73-03-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	3'-Deoxyadenosine			Smiles	C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO

Mechanism of Action

In vitro	Cordycepin increases interleukin (IL)-10 expression, decreased IL-2 expression and suppresses T lymphocyte activity. It also up-regulates IL-1beta, IL-6, IL-8 and TNF-alpha and suppresses phytohemagglutinin (PHA)-induced production of IL-2, IL-4, IL-5, IFN-gamma and IL-12. The structure of this compound is very much similar with cellular nucleoside, adenosine and acts like a nucleoside analogue. It lacks 3' hydroxyl group in its structure. This compound provokes RNA chain termination and interferes in mTOR signal transduction. At higher doses, it inhibits cell attachment and reduces focal adhesion. under low nutritional stress, this chemical activates AMPK which blocks the activity of mTORC1 and mTORC2 complex. The inactivated mTORC2 complex cannot activate AKT 1 kinase fully, which in turn blocks mTOR signal transduction inhibiting translation and further cell proliferation and growth. It also induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules. This compound has anti-tumor effect on mouse melanoma and lung carcinoma cells and human oral cancer cells.
In vivo	Orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects. Oral administration of this compound at dose of 10 mg/kg significantly improves Y-maze learning performance both in healthy and ischemic mice. However, it at dose of 5 mg/kg enhanced Y-maze learning only in ischemic mice but not healthy mice. This chemical significantly decreases the neuronal loss induced by ischemia in hippocampal CA1 and CA3 regions.
References	[1] https://pubmed.ncbi.nlm.nih.gov/19051361/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/ [3] https://pubmed.ncbi.nlm.nih.gov/19131393/ [4] https://pubmed.ncbi.nlm.nih.gov/15649290/ [5] https://pubmed.ncbi.nlm.nih.gov/23819912/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00709215	Unknown status	Refractory TdT-Positive Leukemia	OncoVista Inc.\|AAIPharma	June 2008	Phase 1\|Phase 2

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Cordycepin MMP inhibitor

Chemical Structure

Molecular Weight: 251.24