Metformin

For research use only.

Catalog No.S5958 Synonyms: 1,1-Dimethylbiguanide

7 publications

Metformin Chemical Structure

CAS No. 657-24-9

Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.

Selleck's Metformin has been cited by 7 publications

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Biological Activity

Description Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
Targets
AMPK [1]
()
JNK [1]
()
p38 MAPK [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 26 mg/mL (201.3 mM)
Water 26 mg/mL (201.3 mM)
Ethanol '''26 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 129.16
Formula

C4H11N5

CAS No. 657-24-9
Storage powder
in solvent
Synonyms 1,1-Dimethylbiguanide

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04931017 Not yet recruiting Drug: Extended Release Metformin Hydrochloride Lung Carcinoma National Cancer Institute (NCI) November 1 2021 Phase 2
NCT04945148 Not yet recruiting Drug: Metformin|Radiation: Radiation IMRT|Drug: Temozolomide Glioblastoma IDH-wildtype Hopital Foch|National Cancer Institute France October 2021 Phase 2
NCT04169243 Not yet recruiting Behavioral: New Nordic Diet|Other: Control Gestational Diabetes Mellitus Göteborg University|Swedish Council for Working Life and Social Research October 2021 Not Applicable
NCT04530383 Not yet recruiting Drug: Metformin Hydrochloride Cystic Fibrosis-related Diabetes|Cystic Fibrosis University of Kansas Medical Center September 1 2021 Phase 2

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AMPK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID