Metformin

Catalog No.S5958 Synonyms: 1,1-Dimethylbiguanide

For research use only.

Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.

Metformin Chemical Structure

CAS No. 657-24-9

Selleck's Metformin has been cited by 13 publications

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Biological Activity

Description Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
Targets
AMPK [1]
()
JNK [1]
()
p38 MAPK [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 26 mg/mL
(201.3 mM)
Water 26 mg/mL
(201.3 mM)
Ethanol '''26 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 129.16
Formula

C4H11N5

CAS No. 657-24-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04169243 Not yet recruiting Behavioral: New Nordic Diet|Other: Control Gestational Diabetes Mellitus Göteborg University|Swedish Council for Working Life and Social Research September 2022 Not Applicable
NCT04931017 Not yet recruiting Drug: Extended Release Metformin Hydrochloride Lung Carcinoma National Cancer Institute (NCI) April 20 2022 Phase 2
NCT05131828 Not yet recruiting Drug: Metformin and clemastine in combination|Drug: Placebo Multiple Sclerosis Cambridge University Hospitals NHS Foundation Trust|University of Cambridge February 2022 Phase 2
NCT05181449 Not yet recruiting Behavioral: Twin Precision Treatment Type 2 Diabetes The Cleveland Clinic|Twin Health January 3 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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