Puerarin

Catalog No.S2346 Synonyms: Kakonein

Puerarin Chemical Structure

Molecular Weight(MW): 416.38

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.

Size Price Stock Quantity  
In DMSO USD 250 In stock
USD 88 In stock
USD 148 In stock
USD 268 In stock
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Biological Activity

Description Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
In vitro

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. [1] Pueraria is employed clinically to treat cardiovascular diseases in China. [2] Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. [3]

In vivo In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. [2] LD50: Mice 738mg/kg (i.v.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 86 mg/mL (206.54 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 416.38
Formula

C21H20O9

CAS No. 3681-99-0
Storage powder
in solvent
Synonyms Kakonein

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03676296 Recruiting Cardiovascular Disease Risk Factors The University of Hong Kong|Health and Medical Research Fund Hong Kong September 5 2018 Phase 2
NCT03676296 Recruiting Cardiovascular Disease Risk Factors The University of Hong Kong|Health and Medical Research Fund Hong Kong September 5 2018 Phase 2
NCT03099590 Recruiting Alcohol Drinking|Alcohol Use Disorder|Alcohol Abstinence Mclean Hospital January 1 2018 Phase 2
NCT03099590 Recruiting Alcohol Drinking|Alcohol Use Disorder|Alcohol Abstinence Mclean Hospital January 1 2018 Phase 2
NCT03016793 Unknown status Alveolar Cleft Grafting Cairo University January 2017 Phase 2
NCT03016793 Unknown status Alveolar Cleft Grafting Cairo University January 2017 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID