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Puerarin 5-HT Receptor antagonist

Cat.No.S2346

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
Puerarin 5-HT Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 416.38

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Quality Control

Batch: S234601 DMSO]86 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.80%
99.80

Chemical Information, Storage & Stability

Molecular Weight 416.38 Formula

C21H20O9

 Storage (From the date of receipt)
CAS No. 3681-99-0 Download SDF Storage of Stock Solutions

Synonyms Kakonein Smiles C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 86 mg/mL (206.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. [1] This compound is employed clinically to treat cardiovascular diseases in China. [2] Another study showed that this chemical also possessed anti-cancer properties. It at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. [3]
In vivo
In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, this compound markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. [2] LD50: Mice 738mg/kg (i.v.) [4]
References

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