For research use only.
Catalog No.S2346 Synonyms: Kakonein
Molecular Weight(MW): 416.38
Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
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|Description||Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.|
Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.  Pueraria is employed clinically to treat cardiovascular diseases in China.  Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. 
|In vivo||In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver.  LD50: Mice 738mg/kg (i.v.) |
|In vitro||DMSO||86 mg/mL (206.54 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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