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Jatrorrhizine AChR inhibitor

Cat.No.S3884

Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
Jatrorrhizine AChR inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 338.38

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Quality Control

Batch: S388401 DMSO]67 mg/mL]false]]]false]]]false Purity: 99.37%
99.37

Solubility

In vitro
Batch:

DMSO : 67 mg/mL (198.0 mM)
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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 338.38 Formula

C20H20NO4

 Storage (From the date of receipt)
CAS No. 3621-38-3 Download SDF Storage of Stock Solutions

Synonyms Neprotin, Yatrorizine Smiles COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC

Mechanism of Action

Targets/IC50/Ki
AChE
(Cell-free assay)
872 nM
In vitro
Jatrorrhizine hydrochloride suppresses C8161 cell proliferation in a dose-dependent manner, with a half-maximal inhibitory concentration of 47.4±1.6 μmol/l. however, it does not induce significant cellular apoptosis at doses up to 320 μmol/l. Mechanistic studies show that JH-induced C8161 cell cycle arrest at the G0/G1 transition, which is accompanied by overexpression of the cell cycle-suppressive genes p21 and p27 at higher doses.
In vivo
JH reduces metastatic melanoma cell-mediated neovascularization. JH ameliorates hyperlipidemia via the suppression of lipogenesis and the enhancement of lipid oxidation in the liver.
References

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