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Chondroitin sulfate NF-κB inhibitor

Cat.No.S2416

Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.
Chondroitin sulfate NF-κB inhibitor Chemical Structure

Chemical Structure

Molecular Weight:

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Quality Control

Batch: S241601 Water]97 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99%
99

Chemical Information, Storage & Stability

Molecular Weight Formula

(C14H21NO14S)n

 Storage (From the date of receipt)
CAS No. 9007-28-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O

Solubility

In vitro
Batch:

Water : 97 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04507074 Active not recruiting
Low Back Pain|Obesity
Poznan University of Physical Education
 September 1 2020 Not Applicable
NCT03463499 Completed
Interstitial Cystitis
Samsung Medical Center
 September 22 2017 Not Applicable
NCT03827161 Completed
Healthy Subject|Overweight
Fred Hutchinson Cancer Center
 August 1 2017 Phase 1
NCT01856218 Completed
Mucopolysaccharidosis Type 7
Ultragenyx Pharmaceutical Inc
 November 2013 Phase 1|Phase 2

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