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Chondroitin sulfate

Name: Chondroitin sulfate
Brand: Selleck Chemicals
SKU: S2416
Rating: 5 (2 reviews)

Catalog No.S2416 Purity: 99%

Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.

Chondroitin sulfate Chemical Structure

CAS: 9007-28-7

Selleck's Chondroitin sulfate has been cited by 2 publications

Purity & Quality Control

Batch: S241601 Water] 97 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99%

Chondroitin sulfate Related Products

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Signaling Pathway

NF-κB Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description	Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04507074	Active not recruiting	Low Back Pain\|Obesity	Poznan University of Physical Education	January 1 2020	Not Applicable
NCT03463499	Completed	Interstitial Cystitis	Samsung Medical Center	September 22 2017	Not Applicable
NCT03827161	Completed	Healthy Subject\|Overweight	Fred Hutchinson Cancer Center	August 1 2017	Phase 1
NCT01856218	Completed	Mucopolysaccharidosis Type 7	Ultragenyx Pharmaceutical Inc	November 2013	Phase 1\|Phase 2

Chemical Information & Solubility

Molecular Weight		Formula	(C₁₄H₂₁NO₁₄S)n
CAS No.	9007-28-7	SDF	Download Chondroitin sulfate SDF
Smiles	CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 97 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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