Fisetin

Catalog No.S2298

For research use only.

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

Fisetin Chemical Structure

CAS No. 528-48-3

Selleck's Fisetin has been cited by 14 publications

Purity & Quality Control

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Biological Activity

Description Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
Targets
Sirtuin [1]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-453 NEHDPHVE\WyuII\pZYJqdGm2eTDhd5NigQ>? NVjNZ|g{OCxiMkCsJFQxNCB4MDygPFAtKGGwZDCxNFAhyrWP MXWyOEwhPDhuIHHu[EA4OiCqb4Xydy=> MW\XbZRpKGmwY4LlZZNqdmdiY3;uZ4VvfHKjdHnvcpMhd2ZiZnnz[ZRqdiBqMDygNlAtKDRyLDC2NEwhQDBuIHHu[EAyODBiwsXNLUwhfGincnWge4F{KGFiZHXjdoVie2Vib3Lz[ZJ3\WRiaX6gZ4VtdCCwdX3i[ZIhcW5iZHnm[oVz\W62IITpcYUhcW62ZYL2ZYx{KCh{NDygOFgtKGGwZDC3NkBpd3W{czmu NX3iWFNHOzB2M{G2PVI>
SGC7901 NWLlblQ6WHKxbHnm[ZJifGmxbjDhd5NigQ>? NUXGWGVHOCxiMTygOUwhOTBuIEG1JI9zKDJyINM1US=> MlyyOFghcA>? NGHtdVRqdmirYnn0d{Bxem:uaX\ldoF1cW:w M4D2TVI6QDB3NUiw
A549 NXLZRnU{S2WubDD2bYFjcWyrdImgZZN{[Xl? NID3eGUxNCBzMDygNlAtKDNyIH;yJFQxKML3TR?= NYHhe5JwOjRuIES4JI9zKDd{IHi= M4e3bIZqe2W2aX6ge4F{KGWoZnXjeIl3\SCrbjDpcohq[mm2aX7nJJRp\SCpcn;3eIghd2ZiQUW0PUBk\WyuczDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NIe2[YUzQTR4N{i1PS=>
ARPE-19 NVjRcJIzS2WubDDtbYdz[XSrb36gZZN{[Xl? MnTROUBweiBzMDFOwG0> NVvS[mRiOjRiaB?= Mnv1dJJmfHKnYYTt[Y51KHerdHig[ol{\XSrbjDtZZJs\WSueTDy[YR2[2WmIHPlcIwhdWmpcnH0bY9vKGmwIFXHSk11emWjdHXkJGFTWEVvMUmgZ4VtdHN? NWHEdYQ2Ojl{OU[wO|A>
SCC-23 MVLD[YxtKH[rYXLpcIl1gSCjc4PhfS=> M1joUFAuOTByIN88US=> NHr6bW0zPCCq NXjmOJFI\mm|ZYTpckB{cWewaX\pZ4FvfGy7IHnubIljcXSnZDDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiBqc3nncolncWOjboTsfUB4cGWwIITo[UBkd26lZX70doF1cW:wIHnzJIhq\2incjD0bIFvKDJyIN88UUk> NEfxNHAzQTNzMkWyNC=>
Tca-8113 MV3D[YxtKH[rYXLpcIl1gSCjc4PhfS=> MViwMVExOCEQvF2= MkHSNlQhcA>? MVHmbZNmfGmwIIPp[45q\mmlYX70cJkhcW6qaXLpeIVlKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJEh{cWewaX\pZ4FvfGy7IIfo[Y4hfGinIHPvcoNmdnS{YYTpc44hcXNiaHnnbIVzKHSqYX6gNlAh|ryPKR?= NFHU[|UzQTNzMkWyNC=>
Assay
Methods Test Index PMID
Western blot p-mTOR / mTOR / Raptor / Rictor ; DR3 / pNF-κB / NF-κB ; XBP1s / ATF6 / CHOP / ATF4 / PERK ; p-IKKα/β / IKKβ / IKKα / p-IκBα / IκBα / p-p65 / p65 20530556 19670328 25016296 23861901
Immunofluorescence uPA ; p-4EBP1 / p-eIF4B / p-rpS6 23940799 20530556
Growth inhibition assay Cell viability 19670328

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 57 mg/mL
(199.13 mM)
Ethanol 3 mg/mL
(10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 528-48-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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