(+)-Matrine

Catalog No.S2322

For research use only.

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

(+)-Matrine Chemical Structure

CAS No. 519-02-8

Selleck's (+)-Matrine has been cited by 2 Publications

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Biological Activity

Description Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Targets
κ-opioid receptor [1]
In vitro

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. [1] matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. [2]

In vivo LD50: Mice 157mg/kg (i.p.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 49 mg/mL
(197.29 mM)
Ethanol 49 mg/mL
(197.29 mM)
Water 11 mg/mL warmed
(44.29 mM)

Chemical Information

Molecular Weight 248.36
Formula

C15H24N2O

CAS No. 519-02-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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