(+)-Matrine
Catalog No.S2322
-Matrine-chemical-structure-S2322.gif)
Molecular Weight(MW): 248.36
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Purity & Quality Control
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Biological Activity
| Description | Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. | |
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| Targets |
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| In vitro |
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. [1] matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. [2] |
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| In vivo | LD50: Mice 157mg/kg (i.p.) [3] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 49 mg/mL (197.29 mM) |
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| Ethanol | 49 mg/mL (197.29 mM) | |
| Water | 11 mg/mL warmed (44.29 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 248.36 |
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| Formula | C15H24N2O |
| CAS No. | 519-02-8 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
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