Home Neuronal Signaling Opioid Receptor agonist (+)-Matrine

(+)-Matrine

Catalog No.S2322

For research use only.

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

(+)-Matrine Chemical Structure

CAS No. 519-02-8

Selleck's (+)-Matrine has been cited by 2 Publications

Purity & Quality Control

Choose Selective Opioid Receptor Inhibitors

Related Compound Libraries

Other Opioid Receptor Products

Download Inhibitor Catalog

Download Inhibitor Catalog
Opioid Receptor Signaling Pathways

Opioid Receptor Signaling Pathway Map

Biological Activity

Description Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Targets
κ-opioid receptor [1]
In vitro

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. [1] matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. [2]
In vivo LD50: Mice 157mg/kg (i.p.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

 DMSO 49 mg/mL
(197.29 mM)
Ethanol 49 mg/mL
(197.29 mM)
Water 11 mg/mL warmed
(44.29 mM)

Chemical Information

Molecular Weight 248.36
Formula

C15H24N2O
CAS No. 519-02-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy (+)-Matrine | (+)-Matrine supplier | purchase (+)-Matrine | (+)-Matrine cost | (+)-Matrine manufacturer | order (+)-Matrine | (+)-Matrine distributor