Receptor tyrosine kinases (RTK)s are very important signaling pathway, which not only include growth factor receptors such as EGFR(HER), VEGFR, PDGFR, FGFR, IGF-1R, Mast/stem cell growth factor receptor (c-Met) and HER2, but also other gene products which are expressed by the oncogenes such as SRC, Bcr, c-Met and Abl as well. There are the others targets such as Endothelin receptor type A(ETA-receptor), Fms-like tyrosine kinase receptor-3(FLT-3) and kinases such as Spleen tyrosine kinase(Syk), Tie2 kinase, Anaplastic lymphoma kinase(ALK). Now the hot targets are growth factor receptors. Researchers pay more attention to VEGFR / PDGFR / HER2 inhibitors such as Cediranib (AZD2171), BIBW2992 (Tovok), BIBF1120 (Vargatef), ABT-869 (Linifanib), Imatinib Mesylate, Lapatinib Ditosylate and Sunitinib Malate (Sutent) which suppress tumor.
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