Name: (+)-Catechin
Brand: Selleck Chemicals
SKU: S4722
Availability: InStock
Rating: 5 (3 reviews)

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Quality Control

Batch: Purity: 99.79%

99.79

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection COX Histamine Receptor
Other Antioxidant Inhibitors	Elamipretide (SS-31, MTP-131) EGCG ((-)-Epigallocatechin Gallate) Tangeretin Silymarin Gipsoside Hydroxygenkwanin Rutin (trihydrate) Oleuropein (-)Epicatechin Syringic acid

Solubility

In vitro
Batch:

DMSO : 58 mg/mL (199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 58 mg/mL

Water : 1.8 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.9mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 58 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5 %DMSO 1 95 %Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.41mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 8.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	290.27	Formula	C₁₅H₁₄O₆	Storage (From the date of receipt)	3 years -20°C powder (seal)
CAS No.	154-23-4	Download SDF		Storage of Stock Solutions	Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms	Cianidanol, Catechinic acid, Catechuic acid, Catechin			SMILES	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

Read more about storage stability CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	COX-1 (Cell-based assay) 80 μM COX-2 (Cell-based assay) 130 μM
In vitro	The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM.
In vivo	Dietary catechin significantly delayed tumor onset. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse.
References	[1] http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300009 [2] http://www.nature.com/articles/srep23077 [3] https://pubmed.ncbi.nlm.nih.gov/9741297/ [4] https://pubmed.ncbi.nlm.nih.gov/8187052/ [5] https://pubmed.ncbi.nlm.nih.gov/12324302/ [6] https://pubmed.ncbi.nlm.nih.gov/16957869/ [7] http://cancerres.aacrjournals.org/content/canres/61/1/118.full.pdf

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-09-05)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06015022	RECRUITING	Cirrhosis, Liver	University of Texas Southwestern Medical Center	2024-09-01	PHASE2
NCT07161726	RECRUITING	Mobility Disability	University of Alabama at Birmingham	2026-04-21	PHASE1; PHASE2
NCT04300855	ACTIVE_NOT_RECRUITING	Prostate Cancer; Prostate Adenocarcinoma	H. Lee Moffitt Cancer Center and Research Institute	2020-08-21	PHASE2
NCT04597359	ACTIVE_NOT_RECRUITING	Prostate Carcinoma	ECOG-ACRIN Cancer Research Group	2021-10-05	PHASE2
NCT07149506	ENROLLING_BY_INVITATION	Radiation Dermatitis Acute; Radiation Dermatitis; Fibrosis; Skin	CARLOS FRANCISCO SAAVEDRA GARCIA	2025-09-01	PHASE3
NCT06631820	RECRUITING	Chronic Kidney Disease(CKD); Myosteatosis; Mitochondrial Dysfunction; Muscle Function; Muscle Mass	Karolinska Institutet	2025-01-17

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(+)-Catechin Antioxidant chemical

Chemical Structure

Molecular Weight: 290.27