D-Aspartic acid

Catalog No.S5129 Synonyms: Asp, Aminosuccinic acid, asparagic acid, asparaginic acid

For research use only.

D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

D-Aspartic acid Chemical Structure

CAS No. 1783-96-6

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Biological Activity

Description D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
In vitro

D-aspartate (D-Asp) is an endogenous amino acid present in vertebrate tissues, with particularly high levels in the testis. In vitro studies have demonstrated that D-Asp up-regulates testosterone production in Leydig cells by enhancing expression of the steroidogenic acute regulatory protein. Besides testosterone release, D-Asp induced E2 synthesis through aromatase activation[1].

In vivo In vivo studies indicate that D-Asp indirectly stimulates spermatogenesis through the hypothalamic-pituitary-gonadal axis. The oral and/or intraperitoneal D-Asp administration to adult rats induced an increase of serum progesterone and LH as well as an increase of testis/serum testosterone levels, whereas 17β-estradiol (E2) levels did no change[1]. D-aspartic acid has significant analgesic activity[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: GC-1 cells
  • Concentrations: 200 μM
  • Incubation Time: 30 min, 2 h, 4 h
  • Method:

    Cultures were carried on in the presence of D-Asp (200 μM; diluted in distilled H2O) in different time exposure of the amino acid (30 min, 2 h, 4 h). Control cultures were treated with vehicle alone. At the end of the incubation period, cells were rinsed in PBS, harvested by trypsinization, collected by centrifugation at 1,000g for 10 min and immediately frozen at  80°C for biochemical analyses.

  • (Only for Reference)
Animal Research:

[2]

  • Animal Models: Inbred albino BALB/C mice
  • Dosages: 55, 115, and 230 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 0.01 mg/mL
(0.07 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 133.10
Formula

C4H7NO4

CAS No. 1783-96-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C(C(=O)O)N)C(=O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04064333 Not yet recruiting Device: Slow-Stream Expiratory Muscle Strength Training Dysphagia Oropharyngeal|Dysphagia|Dysphagia Progressive|Aging|Aspiration Pneumonia|Cough Sunnybrook Health Sciences Centre September 2022 Not Applicable
NCT05025865 Not yet recruiting Drug: Sodium Hyaluronate|Drug: Placebo Healthy Controls The Cleveland Clinic March 1 2022 Early Phase 1
NCT04015557 Suspended Drug: Acetaminophen|Drug: N-acetylcysteine CBS Deficiency Hospital de Clinicas de Porto Alegre|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Brazil February 11 2022 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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