Isoliquiritigenin

Catalog No.S2404

For research use only.

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

Isoliquiritigenin Chemical Structure

CAS No. 961-29-5

Selleck's Isoliquiritigenin has been cited by 7 Publications

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Purity & Quality Control

Choose Selective Aldose Reductase Inhibitors

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells NEHjRVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXrDc41xd3WwZDDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SC2aHWg[Zhxd26nboTpZYwh\3Kxd4ToJI9nKEuEIHPlcIx{KGK7IEWwKUwhS0N3ME2xNkDPxE1? M1XNdVk4Pjd4M{K=
MT-4 cells M1PI[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWPiWJF1S2:vcH;1coQh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3WgeIhmKGW6cH;u[Y51cWGuIHfyc5d1cCCxZjDNWE01KGOnbHzzJIJ6KDVyJTygR2M2OD15LkSg{txO M1OxXFk4Pjd4M{K=
Hepa lclc7 cells MWTDfZRwfG:6aXPpeJkh[XO|YYm= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDI[ZBiKGylbHO3JINmdGy|LDDJR|UxRTN7IN88US=> MUCxPFA4PjF2Mh?=
J774.1 cells NWricG4{TnWwY4Tpc44h[XO|YYm= NE\XXGgzPCCq MoHwTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKGmwIH3veZNmKEp5N{SuNUBk\WyuczDh[pRmeiB{NDDodpMh[nliR4Lp[ZN{KHKnYXflcpQh[XO|YYmsJGlEPTB;MkmuN{DPxE1? NXL5UGhFOTV7N{S2NFg>
colon 26-L5 cells MY\DfZRwfG:6aXPpeJkh[XO|YYm= NFrBXHU4OiCq MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDjc4xwdiB{Nj3MOUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJzLkig{txO MkThNVg1PDB{M{O=
MCF7 cells NV;0RnV5S3m2b4TvfIlkcXS7IHHzd4F6 MYOyOU0yPTBizszN NVT5cIR1PzJiaB?= NWHjXFFsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjdDCyOUB1dyBzNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> NVv0dYdCOTh4MEOzN|Y>
CHO cells NWLnUnNvS3m2b4TvfIlkcXS7IHHzd4F6 NHXqZ21EgXSxdH;4bYNqfHliYXfhbY5{fCCFSF:gZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUS1Mlkh|ryP NYnoUmhtOTl3N{K3N|g>
human T47D cells M4i0XmZ2dmO2aX;uJIF{e2G7 MU[5OkBp MoX0SZN1em:pZX7pZ{Bi[3Srdnn0fUBqdiCqdX3hckBVPDeGIHPlcIx{KGG|c3Xzd4VlKGG|IHTyeYchdGW4ZXygZ4F2e2mwZzDzeIlufWyjdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iZYH1bZZidGWwdDD0c{AyOCCyTTDld5Rz[WSrb3ygZYZ1\XJiOU[gbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7 M2DKSFE6QTJ6OEOy
MCF7 cells MlTTSpVv[3Srb36gZZN{[Xl? MWW5OkBp NUTnVWd7TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MnryNVk6Ojh6M{K=
MCF7 cells Ml[wSpVv[3Srb36gZZN{[Xl? MU\Fd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGy3Y3nm[ZJie2VidILhcpNn\WO2ZXSgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BlenWpIHzleoVtKGOjdYPpcoche3SrbYXsZZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIVyfWm4YXzlcpQhfG9iMUCgdG0h\XO2cnHkbY9tKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> NHPBc3cyQTl{OEizNi=>
mouse NIH3T3 cells M1LWXmZ2dmO2aX;uJIF{e2G7 M33RN|ghcA>? NV[5NWtpUW6qaXLpeIlwdiCxZjDjc4JidHRiY3jsc5Jq\GVvaX7keYNm\CCKSV[tNUBi[3SrdnH0bY9vKGW6cILld5Nm\CCrbjDtc5V{\SCQSVizWFMh[2WubIOgZYZ1\XJiODDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUSuPEDPxE1? NGS3NJUzOTFzMke4Ny=>
OE21 cells MWTDfZRwfG:6aXPpeJkh[XO|YYm= NY\wfGFEPzJiaB?= Mn\KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU2UzOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUS4JO69VQ>? MnP6NlE3QTZ7NUS=
U937 cells NEOzXnZHfW6ldHnvckBie3OjeR?= M4fMNlUhfWdxbXy= NXvFNJo1OjRiaB?= M2HifmFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gWVk{PyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEOFTEWgd4VkemW2aX;uJIF1KDVidXevcYwh[W[2ZYKgNlQhcHK|IHL5JGVNUVODIILlcIF1cX[nIITvJINwdnS{b3y= M12wcFIyQDZ4OEm5
dog MDCK cells MWHGeY5kfGmxbjDhd5NigQ>? MnvUNlAhfWdxbVy= M{PrUlEhcA>? MkDrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFGvVJVmenSxIGLpZ48wQC9|NDDINW4yKGmwZnXjeIVlKGmwIHTv[{BOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[XRiMkCgeYcwdUxiaX7jeYJifGWmIHH0JFEhcHJicH;zeE1qdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JIhmdWGpZ3z1eIlvcW6jdHnu[{B2dmm2IHHzd4F6KHKnbHH0bZZmKHSxIHPvcpRzd2x? NVOzdZFxOjJ5NEOwPFY>
dog MDCK cells MkLoSpVv[3Srb36gZZN{[Xl? M4\IcFghcA>? MlfMTY5pcWKrdHnvckBw\iCSS1OvdFM5VUGSSz3t[YRq[XSnZDDueYNt\WG{LXP5eI9xdGG|bXnjJJZqemGuIILpZo9vfWOuZX;wdo91\WmwIHX4dI9zfCCrbjDkc4chVUSFSzDj[YxteyCrbn\lZ5Rm\CC5aYToJGlv\my3ZX76ZUB3cXK3czDBM3B2\XK2bzDSbYNwNzhxM{SgTFFPOSCvZXHzeZJm\CCjdDC4JIhzeyCyb4P0MYlv\mWldHnvckBjgSCrbn3teY5w\my3b4Lld4NmdmOn M1;BUFIzPzR|MEi2
NCI-H292 cells MUPGeY5kfGmxbjDhd5NigQ>? NHvtcYdKdmirYnn0bY9vKG:oIGDLR{1u\WSrYYTl[EBRU0RicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE6FST3INlkzKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDZiaILzJJBwe3RvaX7m[YN1cW:wIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| MXSyNlc1OzB6Nh?=
NCI-H292 cells NYjuc3UxTnWwY4Tpc44h[XO|YYm= NY\SZppUUW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQheDN6TVHQT{BxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gUmNKNUh{OUKgZ4VtdHNiaX7m[YN1\WRid3n0bEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFibXXhd5Vz\WRiYYSgOkBpenNicH;zeE1qdm[nY4Tpc44h[nliaX3teY5w[myxdITpcoch[W6jbInzbZM> MUiyNlc1OzB6Nh?=
NCI-H292 cells NUGw[Zl4TnWwY4Tpc44h[XO|YYm= M13vTGlvcGmkaYTpc44hd2ZiUFvDMY1m\GmjdHXkJGpPUyCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVkOLLViyPVIh[2WubIOgbY5n\WO2ZXSge4l1cCCLbn\seYVvgmFidnnyeZMhSS:SdXXyeI8hWmmlbz:4M|M1KEhzTkGgcYVie3W{ZXSgZZQhPiCqcoOgdI9{fC2rbn\lZ5Rqd25iYomgbY1ufW6xYnzveJRqdmdiYX7hcJl{cXN? MorINlI4PDNyOE[=
dog MDCK cells MVLGeY5kfGmxbjDhd5NigQ>? MkK2VoV{fG:{YYTpc44hd2ZiR2PIJIxmfmWuIHnuJIRw\yCPRFPLJINmdGy|IHnu[oVkfGWmIIfpeIghUW6obIXlcppiKH[rcoXzJGEwWHWncoTvJHJq[29xOD:zOEBJOU5zIH3lZZN2emWmIHH0JFI1KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDEWG5DNWKjc3XkJINwdG:vZYTybYMh[XO|YYm= Mnr1NlI4PDNyOE[=
RBL-1 cells NHv4OIhHfW6ldHnvckBie3OjeR?= M1e0b2lvKH[rdILvJIlvcGmkaYTpc44h[WejaX7zeEA2NWyrcH;4fYdmdmG|ZTDpckBTSkxvMTDj[YxteyC5YYOg[IV1\XKvaX7l[EwhUUN3ME2zOUDPxE1? NX\xXlVpQDJ3NE[yNC=>
PC3 cells MXPDfZRwfG:6aXPpeJkh[XO|YYm= MoXzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzMEBKSzVyPUS2MlQh|ryP M3u0RlE3PDRzME[2
HUVEC M3fRVWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3fkUFQ5KGh? NGHLUHJVd3irY3n0fUBi\2GrboP0JGhWXkWFIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01OS5zNzFOwG0> NVfhNo9HOjV3OUC4OlQ>
K562 cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= MVO0PEBp MkfoRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDpcoN2[mG2ZXSg[o9zKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OjlwMkeg{txO NIO0SYUzPTV7MEi2OC=>
Hepa-1c1c7 cells NGCwPHJHfW6ldHnvckBie3OjeR?= MlLzTY5lfWO2aX;uJI9nKHG3aX7vcoUhemWmdXP0ZZNmKGGldHn2bZR6KGmwIH3veZNmKEincHGtNYMy[zdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 NGXhPWYyOjd4Mke4Oy=>
Hepa lclc7 cells NFfqWY1HfW6ldHnvckBie3OjeR?= MXnJcoR2[3Srb36gc4YhdW:3c3WgdZVqdm:wZTDy[YR2[3Sjc3WgbY4hdW:3c3WgTIVx[SCuY3zjO{Bk\WyuczDhd5Nme3OnZDDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJIRwfWKuZTDlcpp6dWViYXP0bZZqfHl? Mo[2NVgxPzZzNEK=
U937 cells NUjtU|NkTnWwY4Tpc44h[XO|YYm= MnzqOUB2\y:vbB?= MWHJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIFHQMVEh[WO2aY\heIlwdiCrbjDoeY1idiCXOUO3JINmdGy|IHH0JFUhfWdxbXygZYZ1\XJiMTDodkBz\WyjdHn2[UB1dyClb370do9t NHrmdlQzOTh4Nki5PS=>
In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Ethanol 26 mg/mL
(101.46 mM)
DMSO 12 mg/mL
(46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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