Isoliquiritigenin

For research use only.

Catalog No.S2404

5 publications

Isoliquiritigenin Chemical Structure

Molecular Weight(MW): 256.25

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

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10mM (1mL in DMSO) USD 220 In stock
USD 170 In stock
USD 570 In stock
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Selleck's Isoliquiritigenin has been cited by 5 publications

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  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

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Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoHNR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCNQjDj[YxteyCkeTC1NEUtKEOFNUC9NVIh|ryP M1nsTFk4Pjd4M{K=
MT-4 cells MkmxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGDF[2VEd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD0bIUh\Xiyb37lcpRq[WxiZ4Lve5RpKG:oIF3UMVQh[2WubIOgZpkhPTBnLDDDR|UxRTdwNDFOwG0> NEG3Vo86PzZ5NkOy
Hepa lclc7 cells MlvuR5l1d3SxeHnjbZR6KGG|c3H5 MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDI[ZBiKGylbHO3JINmdGy|LDDJR|UxRTN7IN88US=> M3PaPFE5ODd4MUSy
J774.1 cells M{e2NGZ2dmO2aX;uJIF{e2G7 M1rOclI1KGh? MV3Jcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44hcW5ibX;1d4UhUjd5ND6xJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5MhemWjZ3XueEBie3OjeTygTWM2OD1{OT6zJO69VQ>? MYOxOVk4PDZyOB?=
colon 26-L5 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= MUm3NkBp MlrhR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgZ49td25iMk[tUFUh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{MT64JO69VQ>? Mo\iNVg1PDB{M{O=
MCF7 cells MoLGR5l1d3SxeHnjbZR6KGG|c3H5 NVK0UmJHOjVvMUWwJO69VQ>? NUfM[|VbPzJiaB?= MoPhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BifCB{NTD0c{AyPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeR?= M3jFflE5PjB|M{O2
CHO cells MUjDfZRwfG:6aXPpeJkh[XO|YYm= M2[xRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEOKTzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;NEWuPUDPxE1? NUXEOJlnOTl3N{K3N|g>
human T47D cells NVjHSHl{TnWwY4Tpc44h[XO|YYm= MkXLPVYhcA>? M2HVNGV{fHKxZ3XubYMh[WO2aY\peJkhcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDkdpVoKGyndnXsJINifXOrbnegd5RqdXWuYYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHXxeYl3[WynboSgeI8hOTBicF2g[ZN1emGmaX;sJIFnfGW{IEm2JIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeR?= NU\Cd2xFOTl7Mki4N|I>
MCF7 cells NWLJXmpHTnWwY4Tpc44h[XO|YYm= MnPvPVYhcA>? NVTkOpJ4TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MVKxPVkzQDh|Mh?=
MCF7 cells NXH1O5ltTnWwY4Tpc44h[XO|YYm= NV;oSW5mTXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDseYNq\mW{YYPlJJRz[W6|ZnXjeIVlKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDjZZV{cW6pIIP0bY12dGG2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCncYXpeoFt\W62IITvJFExKHCPIHXzeJJi\GmxbDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? MYSxPVkzQDh|Mh?=
mouse NIH3T3 cells MYrGeY5kfGmxbjDhd5NigQ>? NGnPVVA5KGh? MWLJcohq[mm2aX;uJI9nKGOxYnHseEBkcGyxcnnk[U1qdmS3Y3XkJGhKTi1zIHHjeIl3[XSrb36g[ZhxemW|c3XkJIlvKG2xdYPlJG5KUDOWMzDj[YxteyCjZoTldkA5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:PC56IN88US=> M3\6OlIyOTF{N{iz
OE21 cells M2HxN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHWxOoc4OiCq NFju[mtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQTTJzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OFgh|ryP MUKyNVY6Pjl3NB?=
U937 cells MUnGeY5kfGmxbjDhd5NigQ>? NX\kV2xoPSC3Zz;tcC=> M1LiO|I1KGh? M1TGZWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gWVk{PyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEOFTEWgd4VkemW2aX;uJIF1KDVidXevcYwh[W[2ZYKgNlQhcHK|IHL5JGVNUVODIILlcIF1cX[nIITvJINwdnS{b3y= MojuNlE5PjZ6OUm=
dog MDCK cells NX\3Z|FyTnWwY4Tpc44h[XO|YYm= NInXc2czOCC3Zz;tUC=> NYGxPIpSOSCq NH3mUnJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFiaX7m[YN1\WRiaX6g[I9oKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjdDCyNEB2\y:vTDDpcoN2[mG2ZXSgZZQhOSCqcjDwc5N1NWmwZnXjeIlwdiCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhcGWvYXfncJV1cW6rbnH0bY5oKHWwaYSgZZN{[XlicnXsZZRqfmVidH:gZ49vfHKxbB?= MoTtNlI4PDNyOE[=
dog MDCK cells M3TmTWZ2dmO2aX;uJIF{e2G7 NV7WbHBmQCCq MlfOTY5pcWKrdHnvckBw\iCSS1OvdFM5VUGSSz3t[YRq[XSnZDDueYNt\WG{LXP5eI9xdGG|bXnjJJZqemGuIILpZo9vfWOuZX;wdo91\WmwIHX4dI9zfCCrbjDkc4chVUSFSzDj[YxteyCrbn\lZ5Rm\CC5aYToJGlv\my3ZX76ZUB3cXK3czDBM3B2\XK2bzDSbYNwNzhxM{SgTFFPOSCvZXHzeZJm\CCjdDC4JIhzeyCyb4P0MYlv\mWldHnvckBjgSCrbn3teY5w\my3b4Lld4NmdmOn MYWyNlc1OzB6Nh?=
NCI-H292 cells NUjCbGF2TnWwY4Tpc44h[XO|YYm= NIPvV4lKdmirYnn0bY9vKG:oIGDLR{1u\WSrYYTl[EBRU0RicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE6FST3INlkzKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDZiaILzJJBwe3RvaX7m[YN1cW:wIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| M33DPVIzPzR|MEi2
NCI-H292 cells NEi4NnpHfW6ldHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKFCNQz3t[YRq[XSnZDDwN|hOSVCNIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= NV;pbJBMOjJ5NEOwPFY>
NCI-H292 cells MVrGeY5kfGmxbjDhd5NigQ>? NXTqeWV{UW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQhUk6NIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= MoW2NlI4PDNyOE[=
dog MDCK cells NYLvTXJ5TnWwY4Tpc44h[XO|YYm= MYTS[ZN1d3KjdHnvckBw\iCJU1igcIV3\WxiaX6g[I9oKE2GQ1ugZ4VtdHNiaX7m[YN1\WRid3n0bEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFibXXhd5Vz\WRiYYSgNlQhcHK|IIDvd5QucW6oZXP0bY9vKGK7IFTUUmIu[mG|ZXSgZ49td22ndILpZ{Bie3OjeR?= M4rXclIzPzR|MEi2
RBL-1 cells NYjD[2FYTnWwY4Tpc44h[XO|YYm= M1;pcmlvKH[rdILvJIlvcGmkaYTpc44h[WejaX7zeEA2NWyrcH;4fYdmdmG|ZTDpckBTSkxvMTDj[YxteyC5YYOg[IV1\XKvaX7l[EwhUUN3ME2zOUDPxE1? NUPQNIs2QDJ3NE[yNC=>
PC3 cells NWXHWmxSS3m2b4TvfIlkcXS7IHHzd4F6 MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOsJGlEPTB;NE[uOEDPxE1? MXmxOlQ1OTB4Nh?=
HUVEC NHq0OZhEgXSxdH;4bYNqfHliYYPzZZk> MWi0PEBp MUDUc5hq[2m2eTDh[4FqdnO2IFjVWmVEKGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20NU4yPyEQvF2= NIm2VVAzPTV7MEi2OC=>
K562 cells M{PCXmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYq0PEBp M1PuNGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgbY5kfWKjdHXkJIZweiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJ7LkK3JO69VQ>? NGS5engzPTV7MEi2OC=>
Hepa-1c1c7 cells MlTESpVv[3Srb36gZZN{[Xl? MVnJcoR2[3Srb36gc4YheXWrbn;u[UBz\WS3Y4Thd4Uh[WO2aY\peJkhcW5ibX;1d4UhUGWyYT2xZ|FkPyClZXzsd{Bie3Onc4Pl[EBieyCmcoXnJIxmfmWuIILldZVqemWmIITvJIRwfWKuZTDlcpp6dWViYXP0bZZqfHl? NGHiV3QyOjd4Mke4Oy=>
Hepa lclc7 cells NUHsUHJOTnWwY4Tpc44h[XO|YYm= MUjJcoR2[3Srb36gc4YhdW:3c3WgdZVqdm:wZTDy[YR2[3Sjc3WgbY4hdW:3c3WgTIVx[SCuY3zjO{Bk\WyuczDhd5Nme3OnZDDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJIRwfWKuZTDlcpp6dWViYXP0bZZqfHl? NFHoPHIyQDB5NkG0Ni=>
U937 cells NVH4Z2lVTnWwY4Tpc44h[XO|YYm= MYK1JJVoN22u MYnJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIFHQMVEh[WO2aY\heIlwdiCrbjDoeY1idiCXOUO3JINmdGy|IHH0JFUhfWdxbXygZYZ1\XJiMTDodkBz\WyjdHn2[UB1dyClb370do9t NGq4bZkzOTh4Nki5PS=>

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A
Smiles OC1=CC=C(C=C1)\C=C\C(=O)C2=C(O)C=C(O)C=C2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID