Isoliquiritigenin

Catalog No.S2404

Isoliquiritigenin Chemical Structure

Molecular Weight(MW): 256.25

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

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In DMSO USD 220 In stock
USD 170 In stock
USD 570 In stock
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Cited by 2 Publications

1 Customer Review

  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells NXeyfIl5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLPR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCNQjDj[YxteyCkeTC1NEUtKEOFNUC9NVIh|ryP NIr1[Xk6PzZ5NkOy
MT-4 cells NV;sN|lTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfYNYtEd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD0bIUh\Xiyb37lcpRq[WxiZ4Lve5RpKG:oIF3UMVQh[2WubIOgZpkhPTBnLDDDR|UxRTdwNDFOwG0> NF7qfHM6PzZ5NkOy
Hepa lclc7 cells Ml;sR5l1d3SxeHnjbZR6KGG|c3H5 M3\xdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGhmeGFibHPsZ|ch[2WubIOsJGlEPTB;M{mg{txO MmTFNVgxPzZzNEK=
J774.1 cells NGq0dJhHfW6ldHnvckBie3OjeR?= M{WzfVI1KGh? MUnJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44hcW5ibX;1d4UhUjd5ND6xJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5MhemWjZ3XueEBie3OjeTygTWM2OD1{OT6zJO69VQ>? M1[wT|E2QTd2NkC4
colon 26-L5 cells MXzDfZRwfG:6aXPpeJkh[XO|YYm= NXPBc4pJPzJiaB?= M4\CWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJINwdG:wIEK2MWw2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuPEDPxE1? Mof3NVg1PDB{M{O=
MCF7 cells NX[xOo1HS3m2b4TvfIlkcXS7IHHzd4F6 MoLSNlUuOTVyIN88US=> MV63NkBp MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF1KDJ3IITvJFE2OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 MWWxPFYxOzN|Nh?=
CHO cells M3z2SWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkjJR5l1d3SxeHnjbZR6KGGpYXnud5QhS0iRIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD12NT65JO69VQ>? NGDRXXEyQTV5MkezPC=>
human T47D cells NHrK[otHfW6ldHnvckBie3OjeR?= M1PJd|k3KGh? NUSwflV6TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MV:xPVkzQDh|Mh?=
MCF7 cells MY\GeY5kfGmxbjDhd5NigQ>? M3u1Vlk3KGh? NUj2[|R1TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MkjpNVk6Ojh6M{K=
MCF7 cells MUHGeY5kfGmxbjDhd5NigQ>? NFvjZW9Ge3S{b3flcolkKGGldHn2bZR6KGmwIHz1Z4ln\XKjc3WgeJJidnOoZXP0[YQhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCmcoXnJIxmfmWuIHPheZNqdmdic4TpcZVt[XSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGWzdXn2ZYxmdnRidH:gNVAheE1iZYP0doFlcW:uIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? MnOwNVk6Ojh6M{K=
mouse NIH3T3 cells MWTGeY5kfGmxbjDhd5NigQ>? NH\2cJc5KGh? MnXVTY5pcWKrdHnvckBw\iClb3LhcJQh[2iub4Lp[IUucW6mdXPl[EBJUUZvMTDhZ5RqfmG2aX;uJIV5eHKnc4Pl[EBqdiCvb4Xz[UBPUUh|VEOgZ4VtdHNiYX\0[ZIhQCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTRwODFOwG0> M1HX[|IyOTF{N{iz
OE21 cells MV3DfZRwfG:6aXPpeJkh[XO|YYm= MUW3NkBp M37VS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9GOjFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20PEDPxE1? MmPNNlE3QTZ7NUS=
U937 cells MWPGeY5kfGmxbjDhd5NigQ>? M3zlcVUhfWdxbXy= MkDCNlQhcA>? MlnVRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDVPVM4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhS0OONTDz[YNz\XSrb36gZZQhPSC3Zz;tcEBi\nSncjCyOEBpenNiYomgSWxKW0FicnXsZZRqfmVidH:gZ49vfHKxbB?= MWKyNVg3Pjh7OR?=
dog MDCK cells MkjZSpVv[3Srb36gZZN{[Xl? M1zZRVIxKHWpL33M Mn[5NUBp MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgeolzfXNiQT;QeYVzfG9iUnnjc{85NzN2IFixUlEhcW6oZXP0[YQhcW5iZH;nJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBifCB{MDD1[{9uVCCrbnP1ZoF1\WRiYYSgNUBpeiCyb4P0MYlv\mWldHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgbIVu[WepbIX0bY5qdmG2aX7nJJVvcXRiYYPzZZkhemWuYYTpeoUhfG9iY3;ueJJwdA>? NYHacZpLOjJ5NEOwPFY>
dog MDCK cells M4\RXWZ2dmO2aX;uJIF{e2G7 NEn6VVc5KGh? NUCzXJFbUW6qaXLpeIlwdiCxZjDQT2MweDN6TVHQT{1u\WSrYYTl[EBvfWOuZXHyMYN6fG:ybHHzcYlkKH[rcnHsJJJq[m:wdXPs[Y9xem:2ZXnuJIV5eG:{dDDpckBld2diTVTDT{Bk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEA5KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDpco1ufW6xZnz1c5Jme2OnbnPl M4PacVIzPzR|MEi2
NCI-H292 cells MoftSpVv[3Srb36gZZN{[Xl? NXjUPJJ5UW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQhWEuGIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= M4\RPVIzPzR|MEi2
NCI-H292 cells MVLGeY5kfGmxbjDhd5NigQ>? NXTjbotDUW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQheDN6TVHQT{BxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gUmNKNUh{OUKgZ4VtdHNiaX7m[YN1\WRid3n0bEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFibXXhd5Vz\WRiYYSgOkBpenNicH;zeE1qdm[nY4Tpc44h[nliaX3teY5w[myxdITpcoch[W6jbInzbZM> NWX4fIhuOjJ5NEOwPFY>
NCI-H292 cells NGi4VlhHfW6ldHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKFCNQz3t[YRq[XSnZDDKUmsheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG5EUS2KMkmyJINmdGy|IHnu[oVkfGWmIIfpeIghUW6obIXlcppiKH[rcoXzJGEwWHWncoTvJHJq[29xOD:zOEBJOU5zIH3lZZN2emWmIHH0JFYhcHK|IIDvd5QucW6oZXP0bY9vKGK7IHntcZVvd2Kub4T0bY5oKGGwYXz5d4l{ M{nGTVIzPzR|MEi2
dog MDCK cells NH7Wd4lHfW6ldHnvckBie3OjeR?= M3rqdHJme3SxcnH0bY9vKG:oIFfTTEBt\X[nbDDpckBld2diTVTDT{Bk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEAzPCCqcoOgdI9{fC2rbn\lZ5Rqd25iYomgSHRPSi2kYYPl[EBkd2yxbXX0dolkKGG|c3H5 NYjkfXJJOjJ5NEOwPFY>
RBL-1 cells M1vXOWZ2dmO2aX;uJIF{e2G7 NX36bmg6UW5idnn0do8hcW6qaXLpeIlwdiCjZ3HpcpN1KDVvbHnwc5h6\2WwYYPlJIlvKFKETD2xJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVM2KM7:TR?= NEHzdIs5OjV2NkKw
PC3 cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= MkfQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzMEBKSzVyPUS2MlQh|ryP NX74Tnl2OTZ2NEGwOlY>
HUVEC NWe0XnB1S3m2b4TvfIlkcXS7IHHzd4F6 NIXm[oM1QCCq M4\kcnRwgGmlaYT5JIFo[Wmwc4SgTHVXTUNiaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQyNjF5IN88US=> MkPWNlU2QTB6NkS=
K562 cells M1;iXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmfnOFghcA>? MV7BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0zQS5{NzFOwG0> NHnuWoMzPTV7MEi2OC=>
Hepa-1c1c7 cells M2\CbWZ2dmO2aX;uJIF{e2G7 NWDvbW1HUW6mdXP0bY9vKG:oIIH1bY5wdmVicnXkeYN1[XOnIHHjeIl3cXS7IHnuJI1wfXOnIFjldIEuOWNzY{egZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBz\XG3aYLl[EB1dyCmb4XicIUh\W68eX3lJIFkfGm4aYT5 M2jifVEzPzZ{N{i3
Hepa lclc7 cells MlTpSpVv[3Srb36gZZN{[Xl? Mnv6TY5lfWO2aX;uJI9nKG2xdYPlJJF2cW6xbnWgdoVlfWO2YYPlJIlvKG2xdYPlJGhmeGFibHPsZ|ch[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 NFO3cGwyQDB5NkG0Ni=>
U937 cells M{\jc2Z2dmO2aX;uJIF{e2G7 NWDyRXV7PSC3Zz;tcC=> M4nYUGlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgRXAuOSCjY4TpeoF1cW:wIHnuJIh2dWGwIGW5N|ch[2WubIOgZZQhPSC3Zz;tcEBi\nSncjCxJIhzKHKnbHH0bZZmKHSxIHPvcpRzd2x? M1X5fVIyQDZ4OEm5

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID