Isoliquiritigenin

For research use only.

Catalog No.S2404

5 publications

Isoliquiritigenin Chemical Structure

Molecular Weight(MW): 256.25

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

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10mM (1mL in DMSO) USD 220 In stock
USD 170 In stock
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Selleck's Isoliquiritigenin has been cited by 5 publications

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  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

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Choose Selective Aldose Reductase Inhibitors

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells M4nGbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGHyOJhEd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD0bIUh\Xiyb37lcpRq[WxiZ4Lve5RpKG:oIFvCJINmdGy|IHL5JFUxLSxiQ1O1NF0yOiEQvF2= MXK5O|Y4PjN{
MT-4 cells NITBW4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmj5R49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCPVD20JINmdGy|IHL5JFUxLSxiQ1O1NF04NjRizszN NHfaUlc6PzZ5NkOy
Hepa lclc7 cells NIq1XINEgXSxdH;4bYNqfHliYYPzZZk> NHjSWGVEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBJ\XCjIHzjcIM4KGOnbHzzMEBKSzVyPUO5JO69VQ>? M1nuNFE5ODd4MUSy
J774.1 cells NYnYSZBlTnWwY4Tpc44h[XO|YYm= NYnxfoxDOjRiaB?= M3HwTmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCMN{e0MlEh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyC{ZXHn[Y51KGG|c3H5MEBKSzVyPUK5MlMh|ryP NIP0XY0yPTl5NE[wPC=>
colon 26-L5 cells M3zOO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlXxO|IhcA>? MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDjc4xwdiB{Nj3MOUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJzLkig{txO MWGxPFQ1ODJ|Mx?=
MCF7 cells NWTOZ|hvS3m2b4TvfIlkcXS7IHHzd4F6 NXXVXllROjVvMUWwJO69VQ>? MXS3NkBp MlLQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BifCB{NTD0c{AyPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeR?= M{f1OFE5PjB|M{O2
CHO cells NX3KUXhYS3m2b4TvfIlkcXS7IHHzd4F6 M3L6O2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KEOKTzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;NEWuPUDPxE1? NE\k[5kyQTV5MkezPC=>
human T47D cells NHzsdllHfW6ldHnvckBie3OjeR?= NYPpW4J7QTZiaB?= MWHFd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGi3bXHuJHQ1P0RiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDjZZV{cW6pIIP0bY12dGG2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCncYXpeoFt\W62IITvJFExKHCPIHXzeJJi\GmxbDDh[pRmeiB7NjDodpMh[nliYXzhcYFzKGKudXWgZZN{[Xl? NGO4RmoyQTl{OEizNi=>
MCF7 cells MlXySpVv[3Srb36gZZN{[Xl? NGG3[Zk6PiCq MX;Fd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDjZZV{cW6pIIP0bY12dGG2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCncYXpeoFt\W62IITvJFExKHCPIHXzeJJi\GmxbDDh[pRmeiB7NjDodpMh[nliYXzhcYFzKGKudXWgZZN{[Xl? MV[xPVkzQDh|Mh?=
MCF7 cells M2DlTWZ2dmO2aX;uJIF{e2G7 NFf2fpFGe3S{b3flcolkKGGldHn2bZR6KGmwIHz1Z4ln\XKjc3WgeJJidnOoZXP0[YQhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCmcoXnJIxmfmWuIHPheZNqdmdic4TpcZVt[XSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGWzdXn2ZYxmdnRidH:gNVAheE1iZYP0doFlcW:uIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? MknLNVk6Ojh6M{K=
mouse NIH3T3 cells NVHZVlI2TnWwY4Tpc44h[XO|YYm= NVfJfVE1QCCq MoHmTY5pcWKrdHnvckBw\iClb3LhcJQh[2iub4Lp[IUucW6mdXPl[EBJUUZvMTDhZ5RqfmG2aX;uJIV5eHKnc4Pl[EBqdiCvb4Xz[UBPUUh|VEOgZ4VtdHNiYX\0[ZIhQCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTRwODFOwG0> NY\kellMOjFzMUK3PFM>
OE21 cells NWmxd3gzS3m2b4TvfIlkcXS7IHHzd4F6 Mn3FO|IhcA>? M3\G[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9GOjFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20PEDPxE1? MkS5NlE3QTZ7NUS=
U937 cells MkTLSpVv[3Srb36gZZN{[Xl? NGjESnk2KHWpL33s MnfoNlQhcA>? M1[zZWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gWVk{PyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEOFTEWgd4VkemW2aX;uJIF1KDVidXevcYwh[W[2ZYKgNlQhcHK|IHL5JGVNUVODIILlcIF1cX[nIITvJINwdnS{b3y= NXrJVI1QOjF6Nk[4PVk>
dog MDCK cells NF;OfZdHfW6ldHnvckBie3OjeR?= NVzMO4NuOjBidXevcWw> NXTGSIM3OSCq M2[0S2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUB3cXK3czDBM3B2\XK2bzDSbYNwNzhxM{SgTFFPOSCrbn\lZ5Rm\CCrbjDkc4chVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGG2IEKwJJVoN22OIHnuZ5Vj[XSnZDDheEAyKGi{IIDvd5QucW6oZXP0bY9vKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBp\W2jZ3fseZRqdmmwYYTpcochfW6rdDDhd5NigSC{ZXzheIl3\SC2bzDjc451em:u MWmyNlc1OzB6Nh?=
dog MDCK cells NFv2eVRHfW6ldHnvckBie3OjeR?= M13pc|ghcA>? MU\Jcohq[mm2aX;uJI9nKFCNQz;wN|hOSVCNLX3l[IlifGWmIH71Z4xm[XJvY4n0c5Bt[XOvaXOgeolz[Wxicnnic452[2ynb4Dyc5RmcW5iZYjwc5J1KGmwIHTv[{BOTEONIHPlcIx{KGmwZnXjeIVlKHerdHigTY5ndHWnborhJJZqenW|IFGvVJVmenSxIGLpZ48wQC9|NDDINW4yKG2nYYP1doVlKGG2IEigbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KGmwbX31co9ndHWxcnXzZ4Vv[2V? MkDpNlI4PDNyOE[=
NCI-H292 cells NYjaVXd5TnWwY4Tpc44h[XO|YYm= NGf4TlJKdmirYnn0bY9vKG:oIGDLR{1u\WSrYYTl[EBRU0RicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE6FST3INlkzKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDZiaILzJJBwe3RvaX7m[YN1cW:wIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| NETSOI8zOjd2M{C4Oi=>
NCI-H292 cells Mk\rSpVv[3Srb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKFCNQz3t[YRq[XSnZDDwN|hOSVCNIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= NVuyWWwxOjJ5NEOwPFY>
NCI-H292 cells MXjGeY5kfGmxbjDhd5NigQ>? NFPPd25KdmirYnn0bY9vKG:oIGDLR{1u\WSrYYTl[EBLVkticHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE6FST3INlkzKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDZiaILzJJBwe3RvaX7m[YN1cW:wIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| MlPwNlI4PDNyOE[=
dog MDCK cells M4n4NGZ2dmO2aX;uJIF{e2G7 NUW2SGQ{WmW|dH;yZZRqd25ib3[gS3NJKGyndnXsJIlvKGSxZzDNSGNMKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDJ2IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBFXE6ELXLhd4VlKGOxbH;t[ZRzcWNiYYPzZZk> NUnLTGZOOjJ5NEOwPFY>
RBL-1 cells MonYSpVv[3Srb36gZZN{[Xl? NE\OSZNKdiC4aYTyc{BqdmirYnn0bY9vKGGpYXnud5QhPS2uaYDvfJlo\W6jc3WgbY4hWkKOLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQtKEmFNUC9N|Uh|ryP NVfWcVhbQDJ3NE[yNC=>
PC3 cells M{LoTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOsJGlEPTB;NE[uOEDPxE1? MXexOlQ1OTB4Nh?=
HUVEC MVjDfZRwfG:6aXPpeJkh[XO|YYm= M13iUlQ5KGh? M2K0U3RwgGmlaYT5JIFo[Wmwc4SgTHVXTUNiaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQyNjF5IN88US=> NYDVbm5jOjV3OUC4OlQ>
K562 cells NG\PfG5EgXSxdH;4bYNqfHliYYPzZZk> NFHlfWc1QCCq MoTWRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDpcoN2[mG2ZXSg[o9zKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OjlwMkeg{txO NW\CW|ZSOjV3OUC4OlQ>
Hepa-1c1c7 cells M2jMVGZ2dmO2aX;uJIF{e2G7 NHzxWXFKdmS3Y4Tpc44hd2ZicYXpco9v\SC{ZXT1Z5Rie2ViYXP0bZZqfHliaX6gcY92e2ViSHXwZU0y[zGlNzDj[YxteyCjc4Pld5Nm\CCjczDkdpVoKGyndnXsJJJmeXWrcnXkJJRwKGSxdXLs[UBmdnq7bXWgZYN1cX[rdIm= M3HMSVEzPzZ{N{i3
Hepa lclc7 cells NIPXTY5HfW6ldHnvckBie3OjeR?= MkHVTY5lfWO2aX;uJI9nKG2xdYPlJJF2cW6xbnWgdoVlfWO2YYPlJIlvKG2xdYPlJGhmeGFibHPsZ|ch[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 NFXMUGkyQDB5NkG0Ni=>
U937 cells NITT[XVHfW6ldHnvckBie3OjeR?= MX21JJVoN22u NH:xNFNKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGFRNTFiYXP0bZZifGmxbjDpckBpfW2jbjDVPVM4KGOnbHzzJIF1KDVidXevcYwh[W[2ZYKgNUBpeiC{ZXzheIl3\SC2bzDjc451em:u MlfNNlE5PjZ6OUm=

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A
Smiles OC1=CC=C(C=C1)\C=C\C(=O)C2=C(O)C=C(O)C=C2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID