Isoliquiritigenin

Catalog No.S2404

Isoliquiritigenin Chemical Structure

Molecular Weight(MW): 256.25

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

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In DMSO USD 220 In stock
USD 170 In stock
USD 570 In stock
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Cited by 2 Publications

1 Customer Review

  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHFR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCNQjDj[YxteyCkeTC1NEUtKEOFNUC9NVIh|ryP NFfPfYc6PzZ5NkOy
MT-4 cells Mn3DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV25eppGS2:vcH;1coQh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3WgeIhmKGW6cH;u[Y51cWGuIHfyc5d1cCCxZjDNWE01KGOnbHzzJIJ6KDVyJTygR2M2OD15LkSg{txO MYC5O|Y4PjN{
Hepa lclc7 cells NHPs[JNEgXSxdH;4bYNqfHliYYPzZZk> NXq3S|RpS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUGWyYTDsZ4xkPyClZXzsd{whUUN3ME2zPUDPxE1? MmHXNVgxPzZzNEK=
J774.1 cells NH;QPXJHfW6ldHnvckBie3OjeR?= NFK2ZmgzPCCq MULJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44hcW5ibX;1d4UhUjd5ND6xJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5MhemWjZ3XueEBie3OjeTygTWM2OD1{OT6zJO69VQ>? MV6xOVk4PDZyOB?=
colon 26-L5 cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= M1f4WlczKGh? NI\yUnNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBkd2yxbjCyOk1NPSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKxMlgh|ryP Mn\ZNVg1PDB{M{O=
MCF7 cells NHTW[5FEgXSxdH;4bYNqfHliYYPzZZk> MmXXNlUuOTVyIN88US=> NHPKWm84OiCq M{\JS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XRiMkWgeI8hOTVyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NF:1R3UyQDZyM{OzOi=>
CHO cells MkTxR5l1d3SxeHnjbZR6KGG|c3H5 MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBEUE9iY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTR3Lkmg{txO NHWyWGcyQTV5MkezPC=>
human T47D cells NVvweYc3TnWwY4Tpc44h[XO|YYm= NVTlNGRPQTZiaB?= NV3QSHV6TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MXuxPVkzQDh|Mh?=
MCF7 cells MV7GeY5kfGmxbjDhd5NigQ>? MUG5OkBp MUnFd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDjZZV{cW6pIIP0bY12dGG2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCncYXpeoFt\W62IITvJFExKHCPIHXzeJJi\GmxbDDh[pRmeiB7NjDodpMh[nliYXzhcYFzKGKudXWgZZN{[Xl? M1e2elE6QTJ6OEOy
MCF7 cells Mn3CSpVv[3Srb36gZZN{[Xl? NXr1[lJSTXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDseYNq\mW{YYPlJJRz[W6|ZnXjeIVlKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDjZZV{cW6pIIP0bY12dGG2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCncYXpeoFt\W62IITvJFExKHCPIHXzeJJi\GmxbDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? M2\heVE6QTJ6OEOy
mouse NIH3T3 cells M{LqRmZ2dmO2aX;uJIF{e2G7 MUm4JIg> MYTJcohq[mm2aX;uJI9nKGOxYnHseEBkcGyxcnnk[U1qdmS3Y3XkJGhKTi1zIHHjeIl3[XSrb36g[ZhxemW|c3XkJIlvKG2xdYPlJG5KUDOWMzDj[YxteyCjZoTldkA5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:PC56IN88US=> NU\0dnBWOjFzMUK3PFM>
OE21 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= NYDuR5JsPzJiaB?= M2e5OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9GOjFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20PEDPxE1? NVK4bWtMOjF4OU[5OVQ>
U937 cells M3TFT2Z2dmO2aX;uJIF{e2G7 Mkj3OUB2\y:vbB?= NIXlNokzPCCq NUnhW41VSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBWQTN5IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiQ1PMOUB{\WO{ZYTpc44h[XRiNTD1[{9udCCjZoTldkAzPCCqcoOgZpkhTUyLU1GgdoVt[XSrdnWgeI8h[2:wdILvcC=> NYrONZVNOjF6Nk[4PVk>
dog MDCK cells Mn;4SpVv[3Srb36gZZN{[Xl? M{Do[FIxKHWpL33M MYixJIg> MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgeolzfXNiQT;QeYVzfG9iUnnjc{85NzN2IFixUlEhcW6oZXP0[YQhcW5iZH;nJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBifCB{MDD1[{9uVCCrbnP1ZoF1\WRiYYSgNUBpeiCyb4P0MYlv\mWldHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgbIVu[WepbIX0bY5qdmG2aX7nJJVvcXRiYYPzZZkhemWuYYTpeoUhfG9iY3;ueJJwdA>? NEL4dGozOjd2M{C4Oi=>
dog MDCK cells NGjkOodHfW6ldHnvckBie3OjeR?= M2HrcVghcA>? NX3q[JFZUW6qaXLpeIlwdiCxZjDQT2MweDN6TVHQT{1u\WSrYYTl[EBvfWOuZXHyMYN6fG:ybHHzcYlkKH[rcnHsJJJq[m:wdXPs[Y9xem:2ZXnuJIV5eG:{dDDpckBld2diTVTDT{Bk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEA5KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDpco1ufW6xZnz1c5Jme2OnbnPl NXzUZ|drOjJ5NEOwPFY>
NCI-H292 cells NFP0blNHfW6ldHnvckBie3OjeR?= M3SwWGlvcGmkaYTpc44hd2ZiUFvDMY1m\GmjdHXkJHBMTCCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVkOLLViyPVIh[2WubIOgbY5n\WO2ZXSge4l1cCCLbn\seYVvgmFidnnyeZMhSS:SdXXyeI8hWmmlbz:4M|M1KEhzTkGgcYVie3W{ZXSgZZQhPiCqcoOgdI9{fC2rbn\lZ5Rqd25iYomgbY1ufW6xYnzveJRqdmdiYX7hcJl{cXN? M32yPVIzPzR|MEi2
NCI-H292 cells MnzDSpVv[3Srb36gZZN{[Xl? M3LGNmlvcGmkaYTpc44hd2ZiUFvDMY1m\GmjdHXkJJA{QE2DUFugdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIF7DTU1JOjl{IHPlcIx{KGmwZnXjeIVlKHerdHigTY5ndHWnborhJJZqenW|IFGvVJVmenSxIGLpZ48wQC9|NDDINW4yKG2nYYP1doVlKGG2IE[gbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KGmvbYXuc4Jtd3S2aX7nJIFv[Wy7c3nz Mo\SNlI4PDNyOE[=
NCI-H292 cells MnPFSpVv[3Srb36gZZN{[Xl? NYfxPZM4UW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQhUk6NIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= NHO1WFkzOjd2M{C4Oi=>
dog MDCK cells MVXGeY5kfGmxbjDhd5NigQ>? M{LKPXJme3SxcnH0bY9vKG:oIFfTTEBt\X[nbDDpckBld2diTVTDT{Bk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEAzPCCqcoOgdI9{fC2rbn\lZ5Rqd25iYomgSHRPSi2kYYPl[EBkd2yxbXX0dolkKGG|c3H5 M1[2dVIzPzR|MEi2
RBL-1 cells NHfWOVJHfW6ldHnvckBie3OjeR?= MkjSTY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUO1JO69VQ>? MormPFI2PDZ{MB?=
PC3 cells NEfWSVhEgXSxdH;4bYNqfHliYYPzZZk> NWW1TXJRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{NCCLQ{WwQVQ3NjRizszN MYWxOlQ1OTB4Nh?=
HUVEC MV7DfZRwfG:6aXPpeJkh[XO|YYm= M3r5e|Q5KGh? M3zKZ3RwgGmlaYT5JIFo[Wmwc4SgTHVXTUNiaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQyNjF5IN88US=> M{\EOlI2PTlyOE[0
K562 cells MnrmR5l1d3SxeHnjbZR6KGG|c3H5 NXLhVm1JPDhiaB?= NV\S[pdESW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{BqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkmuNlch|ryP MoPENlU2QTB6NkS=
Hepa-1c1c7 cells Ml3ISpVv[3Srb36gZZN{[Xl? NUTiNWI{UW6mdXP0bY9vKG:oIIH1bY5wdmVicnXkeYN1[XOnIHHjeIl3cXS7IHnuJI1wfXOnIFjldIEuOWNzY{egZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBz\XG3aYLl[EB1dyCmb4XicIUh\W68eX3lJIFkfGm4aYT5 MlW3NVI4PjJ5OEe=
Hepa lclc7 cells NF\KWY1HfW6ldHnvckBie3OjeR?= Ml\hTY5lfWO2aX;uJI9nKG2xdYPlJJF2cW6xbnWgdoVlfWO2YYPlJIlvKG2xdYPlJGhmeGFibHPsZ|ch[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 MXOxPFA4PjF2Mh?=
U937 cells M4DjdGZ2dmO2aX;uJIF{e2G7 M2j6d|UhfWdxbXy= M{T0RmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgRXAuOSCjY4TpeoF1cW:wIHnuJIh2dWGwIGW5N|ch[2WubIOgZZQhPSC3Zz;tcEBi\nSncjCxJIhzKHKnbHH0bZZmKHSxIHPvcpRzd2x? NXHrS45ZOjF6Nk[4PVk>

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID