Isoliquiritigenin

For research use only.

Catalog No.S2404

7 publications

Isoliquiritigenin Chemical Structure

CAS No. 961-29-5

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

Selleck's Isoliquiritigenin has been cited by 7 publications

1 Customer Review

  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

Purity & Quality Control

Choose Selective Aldose Reductase Inhibitors

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells M2fsUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlvXR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCNQjDj[YxteyCkeTC1NEUtKEOFNUC9NVIh|ryP NVzDNW9yQTd4N{[zNi=>
MT-4 cells NULPbYxPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYLDc41xd3WwZDDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIILl[JVk\SC2aHWg[Zhxd26nboTpZYwh\3Kxd4ToJI9nKE2WLUSgZ4VtdHNiYomgOVAmNCCFQ{WwQVcvPCEQvF2= NF\WXYI6PzZ5NkOy
Hepa lclc7 cells MoO2R5l1d3SxeHnjbZR6KGG|c3H5 MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDI[ZBiKGylbHO3JINmdGy|LDDJR|UxRTN7IN88US=> NGnDO|YyQDB5NkG0Ni=>
J774.1 cells NGGybm5HfW6ldHnvckBie3OjeR?= MlrzNlQhcA>? M4jtN2lvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCMN{e0MlEh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyC{ZXHn[Y51KGG|c3H5MEBKSzVyPUK5MlMh|ryP M2fsXVE2QTd2NkC4
colon 26-L5 cells MYnDfZRwfG:6aXPpeJkh[XO|YYm= NXT5NINDPzJiaB?= M1LlNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJINwdG:wIEK2MWw2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuPEDPxE1? NHPCPG8yQDR2MEKzNy=>
MCF7 cells NIrYc5BEgXSxdH;4bYNqfHliYYPzZZk> MW[yOU0yPTBizszN NILYbnY4OiCq M2jHXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XRiMkWgeI8hOTVyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= MWOxPFYxOzN|Nh?=
CHO cells MnLiR5l1d3SxeHnjbZR6KGG|c3H5 MkDmR5l1d3SxeHnjbZR6KGGpYXnud5QhS0iRIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD12NT65JO69VQ>? NYO2OpZTOTl3N{K3N|g>
human T47D cells NVHye2dUTnWwY4Tpc44h[XO|YYm= MXG5OkBp M2SxNGV{fHKxZ3XubYMh[WO2aY\peJkhcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDkdpVoKGyndnXsJINifXOrbnegd5RqdXWuYYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHXxeYl3[WynboSgeI8hOTBicF2g[ZN1emGmaX;sJIFnfGW{IEm2JIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeR?= NHHn[pcyQTl{OEizNi=>
MCF7 cells NVW5N3ZtTnWwY4Tpc44h[XO|YYm= MX25OkBp NI\rWWZGe3S{b3flcolkKGGldHn2bZR6KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBk[XW|aX7nJJN1cW23bHH0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDldZVqfmGuZX70JJRwKDFyIIDNJIV{fHKjZHnvcEBi\nSncjC5OkBpenNiYomgZYxidWG{IHLseYUh[XO|YYm= NHvqflUyQTl{OEizNi=>
MCF7 cells NFjRRmNHfW6ldHnvckBie3OjeR?= MWDFd5Rzd2enbnnjJIFkfGm4aYT5JIlvKGy3Y3nm[ZJie2VidILhcpNn\WO2ZXSgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BlenWpIHzleoVtKGOjdYPpcoche3SrbYXsZZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIVyfWm4YXzlcpQhfG9iMUCgdG0h\XO2cnHkbY9tKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> NYHOOoRROTl7Mki4N|I>
mouse NIH3T3 cells NHWwRmdHfW6ldHnvckBie3OjeR?= MV64JIg> NEDNUVhKdmirYnn0bY9vKG:oIHPvZoFtfCClaHzvdoll\S2rbnT1Z4VlKEiLRj2xJIFkfGm4YYTpc44h\XiycnXzd4VlKGmwIH3veZNmKE6LSEPUN{Bk\WyuczDh[pRmeiB6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;ND64JO69VQ>? Moj0NlEyOTJ5OEO=
OE21 cells NH\0NGxEgXSxdH;4bYNqfHliYYPzZZk> MV23NkBp NHnsc4tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQTTJzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OFgh|ryP MlvvNlE3QTZ7NUS=
U937 cells NHG1U2pHfW6ldHnvckBie3OjeR?= NGX1O4o2KHWpL33s M3PjZlI1KGh? MoK3RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDVPVM4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhS0OONTDz[YNz\XSrb36gZZQhPSC3Zz;tcEBi\nSncjCyOEBpenNiYomgSWxKW0FicnXsZZRqfmVidH:gZ49vfHKxbB?= MnXSNlE5PjZ6OUm=
dog MDCK cells MlLySpVv[3Srb36gZZN{[Xl? NIf6fZAzOCC3Zz;tUC=> NIjXUoQyKGh? M2fx[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUB3cXK3czDBM3B2\XK2bzDSbYNwNzhxM{SgTFFPOSCrbn\lZ5Rm\CCrbjDkc4chVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGG2IEKwJJVoN22OIHnuZ5Vj[XSnZDDheEAyKGi{IIDvd5QucW6oZXP0bY9vKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBp\W2jZ3fseZRqdmmwYYTpcochfW6rdDDhd5NigSC{ZXzheIl3\SC2bzDjc451em:u NHjrUoUzOjd2M{C4Oi=>
dog MDCK cells NHXWUHlHfW6ldHnvckBie3OjeR?= NX7xR4hLQCCq M1LpbmlvcGmkaYTpc44hd2ZiUFvDM5A{QE2DUFutcYVlcWG2ZXSgcpVkdGWjcj3jfZRweGyjc33pZ{B3cXKjbDDybYJwdnWlbHXvdJJwfGWrbjDlfJBwenRiaX6g[I9oKE2GQ1ugZ4VtdHNiaX7m[YN1\WRid3n0bEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFibXXhd5Vz\WRiYYSgPEBpenNicH;zeE1qdm[nY4Tpc44h[nliaX7tcZVvd2[udX;y[ZNk\W6lZR?= MX6yNlc1OzB6Nh?=
NCI-H292 cells M1vvNWZ2dmO2aX;uJIF{e2G7 NFm5d5hKdmirYnn0bY9vKG:oIGDLR{1u\WSrYYTl[EBRU0RicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE6FST3INlkzKGOnbHzzJIlv\mWldHXkJJdqfGhiSX7mcJVmdnqjII\pdpV{KEFxUIXldpRwKFKrY3:vPE8{PCCKMV6xJI1m[XO3cnXkJIF1KDZiaILzJJBwe3RvaX7m[YN1cW:wIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| NH;UW3gzOjd2M{C4Oi=>
NCI-H292 cells NYC5UnVuTnWwY4Tpc44h[XO|YYm= MorlTY5pcWKrdHnvckBw\iCSS1OtcYVlcWG2ZXSgdFM5VUGSSzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTlPJMWgzQTJiY3XscJMhcW6oZXP0[YQhf2m2aDDJcoZtfWWwenGgeolzfXNiQT;QeYVzfG9iUnnjc{85NzN2IFixUlEhdWWjc4Xy[YQh[XRiNjDodpMheG:|dD3pcoZm[3Srb36gZpkhcW2vdX7vZoxwfHSrbnegZY5idHm|aYO= NH;rO5MzOjd2M{C4Oi=>
NCI-H292 cells NGq0OotHfW6ldHnvckBie3OjeR?= Mmj3TY5pcWKrdHnvckBw\iCSS1OtcYVlcWG2ZXSgTm5MKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBPS0lvSEK5NkBk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEA3KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDpcY12dm:kbH;0eIlv\yCjbnHsfZNqew>? NFS1dVYzOjd2M{C4Oi=>
dog MDCK cells MlXwSpVv[3Srb36gZZN{[Xl? MlnvVoV{fG:{YYTpc44hd2ZiR2PIJIxmfmWuIHnuJIRw\yCPRFPLJINmdGy|IHnu[oVkfGWmIIfpeIghUW6obIXlcppiKH[rcoXzJGEwWHWncoTvJHJq[29xOD:zOEBJOU5zIH3lZZN2emWmIHH0JFI1KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDEWG5DNWKjc3XkJINwdG:vZYTybYMh[XO|YYm= MWqyNlc1OzB6Nh?=
RBL-1 cells M4r3WWZ2dmO2aX;uJIF{e2G7 NXPUbY85UW5idnn0do8hcW6qaXLpeIlwdiCjZ3HpcpN1KDVvbHnwc5h6\2WwYYPlJIlvKFKETD2xJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVM2KM7:TR?= NX;ySldFQDJ3NE[yNC=>
PC3 cells MUPDfZRwfG:6aXPpeJkh[XO|YYm= MmH1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzMEBKSzVyPUS2MlQh|ryP NY\kW3BOOTZ2NEGwOlY>
HUVEC NE\4dVREgXSxdH;4bYNqfHliYYPzZZk> NXTpToI{PDhiaB?= MXzUc5hq[2m2eTDh[4FqdnO2IFjVWmVEKGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20NU4yPyEQvF2= NVXkVFJ{OjV3OUC4OlQ>
K562 cells NHPESXlEgXSxdH;4bYNqfHliYYPzZZk> M3GxW|Q5KGh? NI\ET29CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{OT6yO{DPxE1? M373VlI2PTlyOE[0
Hepa-1c1c7 cells MUnGeY5kfGmxbjDhd5NigQ>? MlrRTY5lfWO2aX;uJI9nKHG3aX7vcoUhemWmdXP0ZZNmKGGldHn2bZR6KGmwIH3veZNmKEincHGtNYMy[zdiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 NVfkO5N4OTJ5NkK3PFc>
Hepa lclc7 cells MlzISpVv[3Srb36gZZN{[Xl? Mm[4TY5lfWO2aX;uJI9nKG2xdYPlJJF2cW6xbnWgdoVlfWO2YYPlJIlvKG2xdYPlJGhmeGFibHPsZ|ch[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 NVfvRYFqOThyN{[xOFI>
U937 cells M1;ROWZ2dmO2aX;uJIF{e2G7 MoXpOUB2\y:vbB?= MnPKTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDBVE0yKGGldHn2ZZRqd25iaX6gbJVu[W5iVUmzO{Bk\WyuczDheEA2KHWpL33sJIFnfGW{IEGgbJIhemWuYYTpeoUhfG9iY3;ueJJwdA>? NUHBSFZEOjF6Nk[4PVk>

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID