Isoliquiritigenin

Catalog No.S2404

Isoliquiritigenin Chemical Structure

Molecular Weight(MW): 256.25

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.

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In DMSO USD 220 In stock
USD 170 In stock
USD 570 In stock
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Cited by 3 Publications

1 Customer Review

  • Cells expressing wild type EGFR (HCC827 and H1650) or L858R/T790M mutant EGFR (HCC827GR) were treated with different concentration of ILQ for 24 h, and the expression of apoptotic markers was detected by immunoblotting.

    J Biol Chem 2014 289(52), 35839-48. Isoliquiritigenin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
Targets
Aldose reductase [1]
(Cell-free assay)
320 nM
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB cells NX;vepJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mkn2R49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCNQjDj[YxteyCkeTC1NEUtKEOFNUC9NVIh|ryP MVG5O|Y4PjN{
MT-4 cells M1zWUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDzR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCPVD20JINmdGy|IHL5JFUxLSxiQ1O1NF04NjRizszN NXvXZY1tQTd4N{[zNi=>
Hepa lclc7 cells MWHDfZRwfG:6aXPpeJkh[XO|YYm= MnHlR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgTIVx[SCuY3zjO{Bk\WyuczygTWM2OD1|OTFOwG0> M{TYTlE5ODd4MUSy
J774.1 cells M3jyVmZ2dmO2aX;uJIF{e2G7 MUmyOEBp MojRTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKGmwIH3veZNmKEp5N{SuNUBk\WyuczDh[pRmeiB{NDDodpMh[nliR4Lp[ZN{KHKnYXflcpQh[XO|YYmsJGlEPTB;MkmuN{DPxE1? MYmxOVk4PDZyOB?=
colon 26-L5 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= MVG3NkBp M1rvSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJINwdG:wIEK2MWw2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuPEDPxE1? MmnLNVg1PDB{M{O=
MCF7 cells M4T2PWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH;0XmczPS1zNUCg{txO M131cFczKGh? M3[5cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XRiMkWgeI8hOTVyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NGrvTGkyQDZyM{OzOi=>
CHO cells M363[GN6fG:2b4jpZ4l1gSCjc4PhfS=> MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBEUE9iY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTR3Lkmg{txO NW[zTm1nOTl3N{K3N|g>
human T47D cells NVu3R2txTnWwY4Tpc44h[XO|YYm= Ml6zPVYhcA>? NUfCfpA4TXO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{B{fGmvdXzheIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36g[ZF2cX[jbHXueEB1dyBzMDDwUUBme3S{YXTpc4wh[W[2ZYKgPVYhcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 Mn\KNVk6Ojh6M{K=
MCF7 cells MnfGSpVv[3Srb36gZZN{[Xl? NFLiTJM6PiCq NEHndmpGe3S{b3flcolkKGGldHn2bZR6KGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBk[XW|aX7nJJN1cW23bHH0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDldZVqfmGuZX70JJRwKDFyIIDNJIV{fHKjZHnvcEBi\nSncjC5OkBpenNiYomgZYxidWG{IHLseYUh[XO|YYm= NWPKTnVYOTl7Mki4N|I>
MCF7 cells M{\uV2Z2dmO2aX;uJIF{e2G7 M2fKbmV{fHKxZ3XubYMh[WO2aY\peJkhcW5ibIXjbYZmemG|ZTD0doFve2[nY4Tl[EBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGS{dXegcIV3\WxiY3H1d4lv\yC|dHnteYxifGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h\XG3aY\hcIVvfCC2bzCxNEBxVSCnc4TyZYRqd2xiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 NXvPTXB5OTl7Mki4N|I>
mouse NIH3T3 cells MUTGeY5kfGmxbjDhd5NigQ>? M1nURlghcA>? MX\Jcohq[mm2aX;uJI9nKGOxYnHseEBkcGyxcnnk[U1qdmS3Y3XkJGhKTi1zIHHjeIl3[XSrb36g[ZhxemW|c3XkJIlvKG2xdYPlJG5KUDOWMzDj[YxteyCjZoTldkA5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:PC56IN88US=> NYWwZZoxOjFzMUK3PFM>
OE21 cells NWLQTJg1S3m2b4TvfIlkcXS7IHHzd4F6 M1[5OlczKGh? MknpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU2UzOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUS4JO69VQ>? M2LuNVIyPjl4OUW0
U937 cells NHjBUJJHfW6ldHnvckBie3OjeR?= NG\FTm02KHWpL33s MYmyOEBp MVHBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGW5N|ch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBES0x3IIPlZ5JmfGmxbjDheEA2KHWpL33sJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSC{ZXzheIl3\SC2bzDjc451em:u M3O1dVIyQDZ4OEm5
dog MDCK cells MYXGeY5kfGmxbjDhd5NigQ>? NV\zNXZNOjBidXevcWw> M4i0OFEhcA>? M4LlUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUB3cXK3czDBM3B2\XK2bzDSbYNwNzhxM{SgTFFPOSCrbn\lZ5Rm\CCrbjDkc4chVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGG2IEKwJJVoN22OIHnuZ5Vj[XSnZDDheEAyKGi{IIDvd5QucW6oZXP0bY9vKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBp\W2jZ3fseZRqdmmwYYTpcochfW6rdDDhd5NigSC{ZXzheIl3\SC2bzDjc451em:u M1rVVlIzPzR|MEi2
dog MDCK cells NFTE[pVHfW6ldHnvckBie3OjeR?= MmLRPEBp NGL4PGVKdmirYnn0bY9vKG:oIGDLR{9xOziPQWDLMY1m\GmjdHXkJI52[2ynYYKtZ5l1d3CuYYPtbYMhfmm{YXygdoljd263Y3zlc5Bzd3SnaX6g[Zhxd3K2IHnuJIRw\yCPRFPLJINmdGy|IHnu[oVkfGWmIIfpeIghUW6obIXlcppiKH[rcoXzJGEwWHWncoTvJHJq[29xOD:zOEBJOU5zIH3lZZN2emWmIHH0JFghcHK|IIDvd5QucW6oZXP0bY9vKGK7IHnucY12dm:obIXvdoV{[2WwY3W= MkfhNlI4PDNyOE[=
NCI-H292 cells NY[yVHhOTnWwY4Tpc44h[XO|YYm= Mn3xTY5pcWKrdHnvckBw\iCSS1OtcYVlcWG2ZXSgVGtFKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBPS0lvSEK5NkBk\WyuczDpcoZm[3SnZDD3bZRpKEmwZnz1[Y57[SC4aYL1d{BCN1C3ZYL0c{BTcWOxL{ivN|QhUDGQMTDt[YF{fXKnZDDheEA3KGi{czDwc5N1NWmwZnXjeIlwdiCkeTDpcY12dm:kbH;0eIlv\yCjbnHsfZNqew>? NU\FUVl7OjJ5NEOwPFY>
NCI-H292 cells MnvtSpVv[3Srb36gZZN{[Xl? MmTxTY5pcWKrdHnvckBw\iCSS1OtcYVlcWG2ZXSgdFM5VUGSSzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTlPJMWgzQTJiY3XscJMhcW6oZXP0[YQhf2m2aDDJcoZtfWWwenGgeolzfXNiQT;QeYVzfG9iUnnjc{85NzN2IFixUlEhdWWjc4Xy[YQh[XRiNjDodpMheG:|dD3pcoZm[3Srb36gZpkhcW2vdX7vZoxwfHSrbnegZY5idHm|aYO= M{X0[lIzPzR|MEi2
NCI-H292 cells M4DjXmZ2dmO2aX;uJIF{e2G7 NUK1XHU1UW6qaXLpeIlwdiCxZjDQT2MudWWmaXH0[YQhUk6NIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQQ1mtTFI6OiClZXzsd{Bqdm[nY4Tl[EB4cXSqIFnu[ox2\W68YTD2bZJ2eyCDL2D1[ZJ1dyCUaXPvM|gwOzRiSEHONUBu\WG|dYLl[EBifCB4IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= NEDvUHEzOjd2M{C4Oi=>
dog MDCK cells MWPGeY5kfGmxbjDhd5NigQ>? MV;S[ZN1d3KjdHnvckBw\iCJU1igcIV3\WxiaX6g[I9oKE2GQ1ugZ4VtdHNiaX7m[YN1\WRid3n0bEBKdm[udXXufoEhfmm{dYOgRU9RfWW{dH:gVolkdy96L{O0JGgyVjFibXXhd5Vz\WRiYYSgNlQhcHK|IIDvd5QucW6oZXP0bY9vKGK7IFTUUmIu[mG|ZXSgZ49td22ndILpZ{Bie3OjeR?= NFPUNWIzOjd2M{C4Oi=>
RBL-1 cells NIfs[I5HfW6ldHnvckBie3OjeR?= MWfJckB3cXS{bzDpcohq[mm2aX;uJIFo[Wmwc4SgOU1tcXCxeInn[Y5ie2ViaX6gVmJNNTFiY3XscJMhf2G|IHTleIVzdWmwZXSsJGlEPTB;M{Wg{txO NGPvSZQ5OjV2NkKw
PC3 cells NInCPFREgXSxdH;4bYNqfHliYYPzZZk> NV22VHhLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{NCCLQ{WwQVQ3NjRizszN MWmxOlQ1OTB4Nh?=
HUVEC NUDKXHBuS3m2b4TvfIlkcXS7IHHzd4F6 M1HOeFQ5KGh? NHvDVJRVd3irY3n0fUBi\2GrboP0JGhWXkWFIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01OS5zNzFOwG0> NY\SdGc4OjV3OUC4OlQ>
K562 cells MlfFR5l1d3SxeHnjbZR6KGG|c3H5 MV60PEBp NI\MdmZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{OT6yO{DPxE1? MkDwNlU2QTB6NkS=
Hepa-1c1c7 cells NYewcXhuTnWwY4Tpc44h[XO|YYm= NVjB[ZduUW6mdXP0bY9vKG:oIIH1bY5wdmVicnXkeYN1[XOnIHHjeIl3cXS7IHnuJI1wfXOnIFjldIEuOWNzY{egZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBz\XG3aYLl[EB1dyCmb4XicIUh\W68eX3lJIFkfGm4aYT5 NEjyPIkyOjd4Mke4Oy=>
Hepa lclc7 cells MVzGeY5kfGmxbjDhd5NigQ>? MlTiTY5lfWO2aX;uJI9nKG2xdYPlJJF2cW6xbnWgdoVlfWO2YYPlJIlvKG2xdYPlJGhmeGFibHPsZ|ch[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bld3WkbHWg[Y57gW2nIHHjeIl3cXS7 MmHUNVgxPzZzNEK=
U937 cells MmmxSpVv[3Srb36gZZN{[Xl? MWW1JJVoN22u MmXVTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDBVE0yKGGldHn2ZZRqd25iaX6gbJVu[W5iVUmzO{Bk\WyuczDheEA2KHWpL33sJIFnfGW{IEGgbJIhemWuYYTpeoUhfG9iY3;ueJJwdA>? NWPIOJlXOjF6Nk[4PVk>

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >6g/kg (i.g.) [5]

Protocol

Solubility (25°C)

In vitro Ethanol 26 mg/mL (101.46 mM)
DMSO 12 mg/mL (46.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 256.25
Formula

C15H12O4

CAS No. 961-29-5
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID