Home Endocrinology & Hormones Androgen Receptor antagonist 3,3'-Diindolylmethane

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3,3'-Diindolylmethane Androgen Receptor antagonist

Cat.No.S4728

3,3'-Diindolylmethane (DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. This compound is a strong, pure androgen receptor (AR) antagonist.
3,3'-Diindolylmethane Androgen Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 246.31

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Quality Control

Batch: S472801 DMSO]49 mg/mL]false]Ethanol]18 mg/mL]false]Water]Insoluble]false Purity: 98.07%
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98.07

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 246.31 Formula

C17H14N2

 Storage (From the date of receipt)
CAS No. 1968-05-4 Download SDF Storage of Stock Solutions

Synonyms DIM Smiles C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43

Mechanism of Action

Targets/IC50/Ki
Androgen Receptor
In vitro
DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. This compound can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. This chemical alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity.
In vivo
Preliminary studies show this compound is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. This chemical activates ATM in normal tissues. It can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability.
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