Cyclovirobuxine D

For research use only.

Catalog No.S2402 Synonyms: Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D

Cyclovirobuxine D Chemical Structure

CAS No. 860-79-7

Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.

Purity & Quality Control

Biological Activity

Description Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.
In vitro

Cyclovirobuxine D increases cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduces the infarct size induced by ligating the coronary artery in rats. In addition, Cyclovirobuxine D protects rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells. [1] Cyclovirobuxine D facilitates the utilization of intracellular Ca(2+) and prevents the loss of Ca(2+), which may be the underlying mechanism of its protective effect on heart failure. [4]

In vivo Cyclovirobuxine D decreases the weight of venous thrombus in rats. [1] Cyclovirobuxine D causes a primary effect of coronary vasodilatation in anesthetized pigs, which involves mechanisms related to the endothelial release of nitric oxide. [2] In addition, Cyclovirobuxine D is beneficial for heart failure in rats induced by myocardial infarction. [3] LD50: Mice 8.9mg/kg (i.v.), 9.2mg/kg (i.p.), 293mg/kg (i.g.). [5]

Protocol

Solubility (25°C)

In vitro Ethanol 20 mg/mL (49.66 mM)
DMSO Insoluble
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 402.66
Formula

C26H46N2O

CAS No. 860-79-7
Storage powder
in solvent
Synonyms Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D
Smiles CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID