For research use only.
Catalog No.S2402 Synonyms: Bebuxine, CVB-D
CAS No. 860-79-7
Cyclovirobuxine D (Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.
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|Description||Cyclovirobuxine D (Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.|
Cyclovirobuxine D increases cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduces the infarct size induced by ligating the coronary artery in rats. In addition, Cyclovirobuxine D protects rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells.  Cyclovirobuxine D facilitates the utilization of intracellular Ca(2+) and prevents the loss of Ca(2+), which may be the underlying mechanism of its protective effect on heart failure. 
|In vivo||Cyclovirobuxine D decreases the weight of venous thrombus in rats.  Cyclovirobuxine D causes a primary effect of coronary vasodilatation in anesthetized pigs, which involves mechanisms related to the endothelial release of nitric oxide.  In addition, Cyclovirobuxine D is beneficial for heart failure in rats induced by myocardial infarction.  LD50: Mice 8.9mg/kg (i.v.), 9.2mg/kg (i.p.), 293mg/kg (i.g.). |
|In vitro||Ethanol||20 mg/mL (49.66 mM)|
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