Catalog No.S3867 Synonyms: Alpinetin chalcone, cardamomin
Molecular Weight(MW): 270.28
Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
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|Description||Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.|
Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel.
|In vivo||Cardamonin inhibits tumor growth in vivo without serious side effects.|
|In vitro||DMSO||54 mg/mL (199.79 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Alpinetin chalcone, cardamomin|
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