Home NF-κB NF-κB inhibitor (E)-Cardamonin

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(E)-Cardamonin NF-κB inhibitor

Cat.No.S3867

(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.
(E)-Cardamonin NF-κB inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 270.28

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Quality Control

Batch: S386701 DMSO]87 mg/mL]false]]]false]]]false Purity: 99.81%
99.81

Solubility

In vitro
Batch:

DMSO : 87 mg/mL (321.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 270.28 Formula

C16H14O4

 Storage (From the date of receipt)
CAS No. 19309-14-9 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
NF-κB
(Cell-free assay)
TRPA1
(Cell-free assay)
454 nM
In vitro
Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel.
In vivo
Cardamonin inhibits tumor growth in vivo without serious side effects.
References

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