(E)-Cardamonin

Catalog No.S3867 Synonyms: Alpinetin chalcone, cardamomin

For research use only.

(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

(E)-Cardamonin Chemical Structure

CAS No. 19309-14-9

Purity & Quality Control

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Biological Activity

Description (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
Targets
NF-κB [2]
(Cell-free assay)
TRPA1 [1]
(Cell-free assay)
454 nM
In vitro

Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1].

In vivo Cardamonin inhibits tumor growth in vivo without serious side effects[2].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: NPC cells
  • Concentrations: 10 μM
  • Incubation Time: 24, 48 and 72 h
  • Method: Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO, absorbance is measured after 24, 48 and 72 h of treatment.
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: Xenograft model (BALB/c nude mice)
  • Dosages: 5 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 54 mg/mL
(199.79 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.28
Formula

C16H14O4

CAS No. 19309-14-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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