Cardamonin

Catalog No.S3867 Synonyms: Alpinetin chalcone, cardamomin

Cardamonin  Chemical Structure

Molecular Weight(MW): 270.28

Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

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Biological Activity

Description Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
Targets
NF-kB [2]
(Cell-free assay)
TRPA1 [1]
(Cell-free assay)
454 nM
In vitro

Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1].

In vivo Cardamonin inhibits tumor growth in vivo without serious side effects[2].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NPC cells
  • Concentrations: 10 μM
  • Incubation Time: 24, 48 and 72 h
  • Method: Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO, absorbance is measured after 24, 48 and 72 h of treatment.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Xenograft model (BALB/c nude mice)
  • Formulation: 18% ethanol, 10% Tween-80 and 72% distilled water
  • Dosages: 5 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 54 mg/mL (199.79 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.28
Formula

C16H14O4

CAS No. 19309-14-9
Storage powder
in solvent
Synonyms Alpinetin chalcone, cardamomin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID