Catalog No.S2391 Synonyms: Sophoretin
Molecular Weight(MW): 302.24
Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
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|Description||Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.|
Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2.  Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. 
|In vivo||Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. LD50: >3000mg/kg (i.g.) |
|In vitro||DMSO||61 mg/mL (201.82 mM)|
|Ethanol||10 mg/mL (33.08 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03476330||Recruiting||Fanconi Anemia|Squamous Cell Carcinoma||Children''s Hospital Medical Center Cincinnati||May 8 2018||Phase 2|
|NCT00065676||Recruiting||Diabetes Mellitus|Obesity||National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC)||July 29 2003||Phase 2|
|NCT02989129||Withdrawn||Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain||M.D. Anderson Cancer Center||April 2018||Early Phase 1|
|NCT02446795||Recruiting||Renal Cell Carcinoma|Kidney Cancer||Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals||November 2016||Phase 1|Phase 2|
|NCT02866448||Withdrawn||Cardiovascular Disease||University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals||August 2016||Not Applicable|
|NCT02195232||Recruiting||Thromboembolism of Vein VTE in Colorectal Cancer|Thromboembolism of Vein in Pancreatic Cancer|Thromboembolism of Vein in Non-small Cell Lung Cancer||Jeffrey Zwicker MD|Quercegen Pharmaceuticals|National Heart Lung and Blood Institute (NHLBI)|Dana-Farber Cancer Institute||January 2015||Phase 2|Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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