Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells NUKz[2ZGTnWwY4Tpc44h[XO|YYm= NHnPOnpKdmirYnn0bY9vKG:oIILheEBm[3SxLUWnMY52[2ynb4Tp[IF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIJ6KGOjcHnscIFzgSCnbHXjeJJweGixcnXzbZMhdWW2aH;kMEBMcT12NT6zJI5O MWWyNFE1PjR6Mx?=
RBL-1 cells MYfGeY5kfGmxbjDhd5NigQ>? NVfZXlFFUW5idnn0do8hcW6qaXLpeIlwdiCjZ3HpcpN1KDVvbHnwc5h6\2WwYYPlJIlvKFKETD2xJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVAvOiEQvF2= NIHr[2M5OjV2NkKw
HEK293 FS cells MV;GeY5kfGmxbjDhd5NigQ>? NEXuS5BKdmirYnn0bY9vKG:oIF7PXFQh\XiycnXzd4VlKGmwIFjFT|I6OyCIUzDj[YxteyCjc4Pld5Nm\CCjczDINm8zKHC{b3T1Z5Rqd25iYomgTFJQOi:WeYKvUHBQKGG|c3H5MEBKSzVyPUCuOlgh|ryP NVnC[IVrOjB5M{GzOVc>
RAW264.7 cells NFPqNHlHfW6ldHnvckBie3OjeR?= M1THRlI1KGh? MlnvTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIFnfGW{IEK0JIhzeyxiSVO1NF0yNjNizszN NXy2RXRsOjN3NEC5PFE>
human HeLa cells M4HPWmZ2dmO2aX;uJIF{e2G7 MkXrTY5pcWKrdHnvckBw\iCPUmCxJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdUHREPCC2cnHud5BwenRiYomgdoFxcWRiZnnseJJifGmxbjDhd5NigSxiS3m9Nk41KM7:TR?= NYDuRnFrOTl5MkW1O|g>
HT22 cells MkTOSpVv[3Srb36gZZN{[Xl? NVfKd5pTUW6qaXLpeIlwdiCxZjDncJV1[W2jdHWtbY5lfWOnZDDvfJl1d3OrczDv[kBud3W|ZTDobZBxd2OjbYDhcEBJXDJ{IHPlcIx{NCCHQ{WwQVIvQThizszN NELMPJUyPjN7MkixOC=>
HT22 cells NWOyZY9jTnWwY4Tpc44h[XO|YYm= MYXO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP MWiyOFYxOjlyNB?=
NCI-H1792 cells M4r3NGZ2dmO2aX;uJIF{e2G7 MWnBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPzl{IHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD1|Lki1JO69VQ>? NWX3PHVGOjVzM{m1Olk>
human BV2 cells NX\3PXQ{TnWwY4Tpc44h[XO|YYm= MV2yOEBp M13xUmlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjDpckBpfW2jbjDCWlIh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME20MlMh|ryP M2rMO|I2OTJ5MU[0
human HTLA cells NIntbYJHfW6ldHnvckBie3OjeR?= Mnr2NlAhdWmwcx?= M1z3c2lvcGmkaYTpc44hd2ZiQ2izR2wyNXO2aX31cIF1\WRiQ2izR3IyKGmwIHj1cYFvKEiWTFGgZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMkCgcYlveyCvZXHzeZJm\CCxbjDkZZkhPCCkeTDi[ZRiKGG{cnXzeIlvNXKnY4L1bZRu\W62IH3l[IlifGWmIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME20MlUh|ryP NXnUd4R{OjN2M{e3O|I>
human LOXIMVI cells NFrXfIJHfW6ldHnvckBie3OjeR?= MkD0RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTRwNkWg{txO Mn3KNlUyOzl3Nkm=
Jurkat T cells MYXGeY5kfGmxbjDhd5NigQ>? NHLycZhC[3Srdnn0fUBi\2GrboP0JIh6\HKxZ3XuJJBmem:6aXTlJIlv\HWlZXSgSG5CKGSjbXHn[UBqdiCMdYLrZZQhXCClZXzsd{whUUN3ME21JO69VQ>? M4LNVlE3Ozl{OEG0
human HCT116 cells NWHaNmNST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoTFOFghcA>? NEjBNnZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNib4\ldoV5eHKnc4PpcochWEl|S3HsdIhiKEhzMES3VkBufXSjboSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13Lkeg{txO MYWyNlIyOjd{MR?=
human NCI-H522 cells MofnSpVv[3Srb36gZZN{[Xl? M{\3fWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDV{MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;NT63O{DPxE1? M4\qO|I2OTN7NU[5
human U2OS cells M3zzN2Z2dmO2aX;uJIF{e2G7 MWjB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIGWyU3Mh[2WubIOgZ49mgHC{ZYPzbY5oKEejbEStWnAyPi2WRW[gZZN{\XO|ZXSgZZMh[mW2YTDhdpJme3SrbjD0doFve2yxY3H0bY9vKGGodHXyJFUhcHK|IHL5JIJmfGFibHHjeIFu[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;NT65N{DPxE1? MXWyOFkxODR2Nx?=
human NCI-H157 cells MknoSpVv[3Srb36gZZN{[Xl? NGHDVWJCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzNUegZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPU[g{txO M2\NNlI2OTN7NU[5
human A549 cells NEnBeVdHfW6ldHnvckBie3OjeR?= NV:yTnM3SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTZwMjFOwG0> M3vMcVI2OTN7NU[5
human HCT116 cells M4DoPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn;xOFghcA>? NXTXOYpkT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi55IN88US=> MmHvNlIzOTJ5MkG=
MDCK cells NIjDUXJHfW6ldHnvckBie3OjeR?= NHv0eYJKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP M4n3XlIyOzV2OECw
human HOP62 cells NE\4dlhHfW6ldHnvckBie3OjeR?= MlK4RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjPVFYzKGOnbHzzJIJ6KEiWUzDhd5NigSxiSVO1NF04NjV{IN88US=> M2TnNFI2OTN7NU[5
human H460 cells M3vCTGZ2dmO2aX;uJIF{e2G7 MkLZRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFi0OlAh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVkvPjJizszN NFXH[o8zPTF|OUW2PS=>
human BV2 cells M13Nb2Z2dmO2aX;uJIF{e2G7 NWnYTXpUSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBDXjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBjgSCJcnnld5Mh[XO|YYmsJGlEPTB;MUCg{txO MoLhNlQ4ODd7M{i=
human MCF7 cells NFLlUWNEgXSxdH;4bYNqfHliYYPzZZk> MnvDO|IhcA>? M{H3UGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKwMlkh|ryP NVXGRllNOjV7ME[zPFU>
human 2008 cells NGPFd29EgXSxdH;4bYNqfHliYYPzZZk> MX[3NkBp NFXzcI9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAzODB6IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNU4yQCEQvF2= M{HE[FI2QTB4M{i1
human A431 cells MmLJR5l1d3SxeHnjbZR6KGG|c3H5 NWfkXW1GPzJiaB?= MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Mz6wOEDPxE1? NX7PU3RQOjV7ME[zPFU>
human BxPC3 cells NHjHXHZEgXSxdH;4bYNqfHliYYPzZZk> NYq0flFkPzJiaB?= MmTlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUK0MlEzKM7:TR?= M{X5XlI2QTB4M{i1
human HepG2 cells NXzaZWo1S3m2b4TvfIlkcXS7IHHzd4F6 NUD4e3dnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUOwMlkh|ryP M3;NblIyPzJ4MEe3
human MDA-MB-231 cells MX3GeY5kfGmxbjDhd5NigQ>? M{fEXlIxKM7:TR?= M1TrelEzKGh? M2HmPGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MnX1NlE3PTJ{MEi=

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03476330 Recruiting Fanconi Anemia|Squamous Cell Carcinoma Children''s Hospital Medical Center Cincinnati May 8 2018 Phase 2
NCT00065676 Recruiting Diabetes Mellitus|Obesity National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) July 29 2003 Phase 2
NCT02989129 Withdrawn Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center April 2018 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 Not Applicable
NCT02195232 Recruiting Thromboembolism of Vein VTE in Colorectal Cancer|Thromboembolism of Vein in Pancreatic Cancer|Thromboembolism of Vein in Non-small Cell Lung Cancer Jeffrey Zwicker MD|Quercegen Pharmaceuticals|National Heart Lung and Blood Institute (NHLBI)|Dana-Farber Cancer Institute January 2015 Phase 2|Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID