Quercetin

For research use only.

Catalog No.S2391 Synonyms: Sophoretin

7 publications

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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Selleck's Quercetin has been cited by 7 publications

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells NXHDZpBtTnWwY4Tpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKHKjdDDlZ5RwNTVpLX71Z4xmd3SrZHHz[UBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHL5JINieGmubHHyfUBmdGWldILvdIhwemW|aYOgcYV1cG:mLDDLbV01PS5|IH7N NF:2bXQzODF2NkS4Ny=>
RBL-1 cells NXy5T21bTnWwY4Tpc44h[XO|YYm= NVPlW2JmUW5idnn0do8hcW6qaXLpeIlwdiCjZ3HpcpN1KDVvbHnwc5h6\2WwYYPlJIlvKFKETD2xJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVAvOiEQvF2= MXS4NlU1PjJy
HEK293 FS cells M2PxNmZ2dmO2aX;uJIF{e2G7 NW\NRWl[UW6qaXLpeIlwdiCxZjDOU3g1KGW6cILld5Nm\CCrbjDISWszQTNiRmOgZ4VtdHNiYYPz[ZN{\WRiYYOgTFJQOiCycn;keYN1cW:wIHL5JGgzVzJxVInyM2xRVyCjc4PhfUwhUUN3ME2wMlY5KM7:TR?= M2XQcVIxPzNzM{W3
RAW264.7 cells NXLtS|hITnWwY4Tpc44h[XO|YYm= MYqyOEBp MWjJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44hcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZYZ1\XJiMkSgbJJ{NCCLQ{WwQVEvOyEQvF2= MVqyN|U1ODl6MR?=
human HeLa cells MVnGeY5kfGmxbjDhd5NigQ>? M2ntWGlvcGmkaYTpc44hd2ZiTWLQNUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{PIYWxVSzRidILhcpNxd3K2IHL5JJJieGmmIH\pcJRz[XSrb36gZZN{[XluIFvpQVIvPCEQvF2= NW\4Xod{OTl5MkW1O|g>
HT22 cells M2TsVmZ2dmO2aX;uJIF{e2G7 MmTETY5pcWKrdHnvckBw\iCpbIX0ZY1ifGVvaX7keYNm\CCxeIn0c5NqeyCxZjDtc5V{\SCqaYDwc4NidXCjbDDIWFIzKGOnbHzzMEBGSzVyPUKuPVgh|ryP MmjiNVY{QTJ6MUS=
HT22 cells MXvGeY5kfGmxbjDhd5NigQ>? MUHO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP MnfuNlQ3ODJ7MES=
NCI-H1792 cells M3nuN2Z2dmO2aX;uJIF{e2G7 MkPJRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTd7MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;Mz64OUDPxE1? NHT2Ro4zPTF|OUW2PS=>
human BV2 cells NHjEXZdHfW6ldHnvckBie3OjeR?= MV2yOEBp NITQS2RKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36gbY4hcHWvYX6gRnYzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDHdolme3NiYYPzZZktKEmFNUC9OE4{KM7:TR?= MVWyOVEzPzF4NB?=
human HTLA cells NF3qflJHfW6ldHnvckBie3OjeR?= MUmyNEBucW6| MmDnTY5pcWKrdHnvckBw\iCFWEPDUFEue3SrbYXsZZRm\CCFWEPDVlEhcW5iaIXtZY4hUFSOQTDj[YxteyCycnWtbY5kfWKjdHXkJIZweiB{MDDtbY5{KG2nYYP1doVlKG:wIHThfUA1KGK7IHLleIEh[XK{ZYP0bY4uemWlcoXpeI1mdnRibXXkbYF1\WRibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUSuOUDPxE1? NUTGOnZSOjN2M{e3O|I>
human LOXIMVI cells NG\DSHJHfW6ldHnvckBie3OjeR?= NGDBbWNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUG9ZUU2YSTDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;ND62OUDPxE1? M3XlOFI2OTN7NU[5
Jurkat T cells MmDkSpVv[3Srb36gZZN{[Xl? MnfRRYN1cX[rdImgZYdicW6|dDDofYRzd2enbjDw[ZJwgGmmZTDpcoR2[2WmIFTORUBl[W2jZ3WgbY4hUnW{a3H0JHQh[2WubIOsJGlEPTB;NTFOwG0> M37TcFE3Ozl{OEG0
human HCT116 cells M4n1NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\hOFghcA>? M1fTOmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNzFOwG0> NX\SNoZuOjJ{MUK3NlE>
human NCI-H522 cells MkfiSpVv[3Srb36gZZN{[Xl? MUTBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg2OjJiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTVwN{eg{txO NIiwR5YzPTF|OUW2PS=>
human U2OS cells NHLZS4ZHfW6ldHnvckBie3OjeR?= NV7TUFVESWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVUvQTNizszN MXKyOFkxODR2Nx?=
human NCI-H157 cells M2PycGZ2dmO2aX;uJIF{e2G7 MVHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPTdiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTZizszN NIDZNVAzPTF|OUW2PS=>
human A549 cells M{HxOWZ2dmO2aX;uJIF{e2G7 MYDBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9Ok4zKM7:TR?= MUmyOVE{QTV4OR?=
human HCT116 cells M3\sNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37OZlQ5KGh? MnjOS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok44KM7:TR?= NF;uUnMzOjJzMkeyNS=>
MDCK cells M1LFOmZ2dmO2aX;uJIF{e2G7 MorXTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IIXzbY5oKEixZXPod5QhOzN|NEKgd5RicW6rbnesJGlEPTB;Nj65JO69VQ>? Mn;FNlE{PTR6MEC=
human HOP62 cells MVjGeY5kfGmxbjDhd5NigQ>? NHvwSmhCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTG9RPjJiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTdwNUKg{txO M1P4c|I2OTN7NU[5
human H460 cells NGO5bmVHfW6ldHnvckBie3OjeR?= MXHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9PU43OiEQvF2= NITpRW0zPTF|OUW2PS=>
human BV2 cells NHXsVXFHfW6ldHnvckBie3OjeR?= MmLVRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDCWlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDifUBIemmnc4OgZZN{[XluIFnDOVA:OTBizszN NV7EOZBlOjR5MEe5N|g>
human MCF7 cells NYPIVG9yS3m2b4TvfIlkcXS7IHHzd4F6 NEfSPGU4OiCq Mmn2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkCuPUDPxE1? M{fsc|I2QTB4M{i1
human 2008 cells MoDlR5l1d3SxeHnjbZR6KGG|c3H5 NFvBR4w4OiCq MoLvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNlAxQCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuNVgh|ryP M4jndFI2QTB4M{i1
human A431 cells MX\DfZRwfG:6aXPpeJkh[XO|YYm= M2nrc|czKGh? MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Mz6wOEDPxE1? M4fUfFI2QTB4M{i1
human BxPC3 cells NYfydYF4S3m2b4TvfIlkcXS7IHHzd4F6 M3nLPVczKGh? MkTuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUK0MlEzKM7:TR?= NYjJZ2ozOjV7ME[zPFU>
human HepG2 cells NUm1RnpbS3m2b4TvfIlkcXS7IHHzd4F6 NVeweWRiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUOwMlkh|ryP MmruNlE4OjZyN{e=
human MDA-MB-231 cells NYTrOph1TnWwY4Tpc44h[XO|YYm= NFy4XoIzOCEQvF2= NVe5dG5OOTJiaB?= MYjJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNiY3zlZZZm\CClYYPwZZNmNTdiYXPjeY12dGG2aX;uJIF1KDJyIIXNJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NGDlfZczOTZ3MkKwPC=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

27175602 18655187
Growth inhibition assay
Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

27175602 28280414
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin
Smiles OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Suspended Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID