Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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Cited by 4 Publications

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells NFPleWxHfW6ldHnvckBie3OjeR?= NVLWU5YzUW6qaXLpeIlwdiCxZjDyZZQh\WO2bz21K{1vfWOuZX;0bYRie2ViZYjwdoV{e2WmIHnuJHNnQSClZXzsd{BjgSClYYDpcIxienliZXzlZ5Rzd3Cqb4Lld4l{KG2ndHjv[EwhU2l;NEWuN{BvVQ>? Mn3rNlAyPDZ2OEO=
RBL-1 cells MXLGeY5kfGmxbjDhd5NigQ>? MnvXTY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUCuNkDPxE1? NYXpPGJ4QDJ3NE[yNC=>
HEK293 FS cells M120dGZ2dmO2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO MkPYNlA4OzF|NUe=
RAW264.7 cells MV\GeY5kfGmxbjDhd5NigQ>? NXXXS4xVOjRiaB?= NXLXXIV[UW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBPVyCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFI1KGi{czygTWM2OD1zLkOg{txO NVrU[pd4OjN3NEC5PFE>
human HeLa cells NIDV[GxHfW6ldHnvckBie3OjeR?= NUnvbGJHUW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> NHi4cIcyQTd{NUW3PC=>
HT22 cells M1G1dWZ2dmO2aX;uJIF{e2G7 MV;Jcohq[mm2aX;uJI9nKGeudYThcYF1\S2rbnT1Z4VlKG:6eYTvd4l{KG:oIH3veZNmKGircIDvZ4FueGGuIFjUNlIh[2WubIOsJGVEPTB;Mj65PEDPxE1? MUexOlM6OjhzNB?=
HT22 cells MUTGeY5kfGmxbjDhd5NigQ>? MYPO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP MoPWNlQ3ODJ7MES=
NCI-H1792 cells MonZSpVv[3Srb36gZZN{[Xl? NYr2b|VTSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUe5NkBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9N{45PSEQvF2= MmroNlUyOzl3Nkm=
human BV2 cells M4DWTWZ2dmO2aX;uJIF{e2G7 MmDPNlQhcA>? M4rGW2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjDpckBpfW2jbjDCWlIh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME20MlMh|ryP MmTZNlUyOjdzNkS=
human HTLA cells M4f6XmZ2dmO2aX;uJIF{e2G7 MWWyNEBucW6| NHLDXnpKdmirYnn0bY9vKG:oIFPYN2NNOS2|dHnteYxifGWmIFPYN2NTOSCrbjDoeY1idiCKVFzBJINmdGy|IIDy[U1qdmO3YnH0[YQh\m:{IEKwJI1qdnNibXXhd5Vz\WRib36g[IF6KDRiYomgZoV1[SCjcoLld5Rqdi2{ZXPyeYl1dWWwdDDt[YRq[XSnZDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9OE42KM7:TR?= Mn;5NlM1Ozd5N{K=
human LOXIMVI cells MnHYSpVv[3Srb36gZZN{[Xl? MoHhRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTRwNkWg{txO M3TEWlI2OTN7NU[5
Jurkat T cells NUSzS4d1TnWwY4Tpc44h[XO|YYm= NXLxNphPSWO2aY\peJkh[WejaX7zeEBpgWS{b3flckBx\XKxeHnk[UBqdmS3Y3XkJGRPSSCmYX3h[4UhcW5iSoXyb4F1KFRiY3XscJMtKEmFNUC9OUDPxE1? NHnndpcyPjN7MkixOC=>
human HCT116 cells NGTzN4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXfa[5dQPDhiaB?= M4\vRWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNzFOwG0> MWiyNlIyOjd{MR?=
human NCI-H522 cells M1j4SmZ2dmO2aX;uJIF{e2G7 M4TTZ2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDV{MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;NT63O{DPxE1? NI\TR3ozPTF|OUW2PS=>
human U2OS cells NFLRdYtHfW6ldHnvckBie3OjeR?= NX;NcphuSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVUvQTNizszN NIHRUpIzPDlyMES0Oy=>
human NCI-H157 cells M2DGZ2Z2dmO2aX;uJIF{e2G7 M3vROWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF3NzDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;NjFOwG0> MWKyOVE{QTV4OR?=
human A549 cells MULGeY5kfGmxbjDhd5NigQ>? M3;EemFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KEiWUzDhd5NigSxiSVO1NF03NjJizszN NXfaZVBkOjVzM{m1Olk>
human HCT116 cells Mki1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWe0PEBp MVLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22Mlch|ryP NWj2WZY1OjJ{MUK3NlE>
MDCK cells MWrGeY5kfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD14Lkmg{txO M1XTfFIyOzV2OECw
human HOP62 cells NVzwWYd2TnWwY4Tpc44h[XO|YYm= MVjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF;QOlIh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVcvPTJizszN NHH5cmszPTF|OUW2PS=>
human H460 cells MUXGeY5kfGmxbjDhd5NigQ>? MYPBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9PU43OiEQvF2= MnPYNlUyOzl3Nkm=
human BV2 cells MXjGeY5kfGmxbjDhd5NigQ>? MW\BcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFLWNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHL5JGdzcWW|czDhd5NigSxiSVO1NF0yOCEQvF2= Mmi3NlQ4ODd7M{i=
human MCF7 cells MonjR5l1d3SxeHnjbZR6KGG|c3H5 NGfITZM4OiCq MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{MD65JO69VQ>? NVjzcJNvOjV7ME[zPFU>
human 2008 cells NX7yO3dUS3m2b4TvfIlkcXS7IHHzd4F6 MXS3NkBp MmDaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNlAxQCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuNVgh|ryP MXGyOVkxPjN6NR?=
human A431 cells NELIVoxEgXSxdH;4bYNqfHliYYPzZZk> MXO3NkBp MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Mz6wOEDPxE1? MmXPNlU6ODZ|OEW=
human BxPC3 cells MlvYR5l1d3SxeHnjbZR6KGG|c3H5 MVm3NkBp NFXFcmxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlQvOTJizszN MojpNlU6ODZ|OEW=
human HepG2 cells Ml7IR5l1d3SxeHnjbZR6KGG|c3H5 M4nB[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65JO69VQ>? M2Xv[VIyPzJ4MEe3
human MDA-MB-231 cells NWPnTnN6TnWwY4Tpc44h[XO|YYm= M{XOeFIxKM7:TR?= MmHpNVIhcA>? NI\ieGhKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4xm[X[nZDDjZZNx[XOnLUegZYNkfW23bHH0bY9vKGG2IEKwJJVOKGGodHXyJFEzKGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NWXZWmRWOjF4NUKyNFg>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

27175602 18655187
Growth inhibition assay
Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

27175602 28280414
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Not yet recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic December 2019 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID