Quercetin

For research use only.

Catalog No.S2391 Synonyms: Sophoretin

11 publications

Quercetin Chemical Structure

CAS No. 117-39-5

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

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Selleck's Quercetin has been cited by 11 publications

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells NE\0WZpHfW6ldHnvckBie3OjeR?= M4Xk[2lvcGmkaYTpc44hd2ZicnH0JIVkfG9vNTetcpVkdGWxdHnkZZNmKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZpkh[2GyaXzsZZJ6KGWuZXP0do9xcG:{ZYPpd{Bu\XSqb3SsJGtqRTR3LkOgcm0> NYHjSIxHOjBzNE[0PFM>
RBL-1 cells NWTNUJBLTnWwY4Tpc44h[XO|YYm= MkW0TY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUCuNkDPxE1? NFq2O4Q5OjV2NkKw
HEK293 FS cells M2j4PGZ2dmO2aX;uJIF{e2G7 MVTJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO MmLUNlA4OzF|NUe=
RAW264.7 cells NFmybmpHfW6ldHnvckBie3OjeR?= NGTJPGIzPCCq M1rNTmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OS5|IN88US=> MUmyN|U1ODl6MR?=
human HeLa cells M2\vSGZ2dmO2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP NVTqXmM4OTl5MkW1O|g>
HT22 cells NV\jSXd1TnWwY4Tpc44h[XO|YYm= NFfXNllKdmirYnn0bY9vKG:oIHfseZRidWG2ZT3pcoR2[2WmIH;4fZRwe2m|IH;mJI1wfXOnIHjpdJBw[2GvcHHsJGhVOjJiY3XscJMtKEWFNUC9Nk46QCEQvF2= NHu1UI4yPjN7MkixOC=>
HT22 cells NGft[GFHfW6ldHnvckBie3OjeR?= NXvwSXBCVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIH;4bYRifGm4ZTDkZY1i\2ViYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiRVO1NF0{NjF|IN88US=> Mn\UNlQ3ODJ7MES=
NCI-H1792 cells NEjtPGtHfW6ldHnvckBie3OjeR?= NXn4UZhNSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUe5NkBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9N{45PSEQvF2= NXT1S5ZWOjVzM{m1Olk>
human BV2 cells NYHZd|UzTnWwY4Tpc44h[XO|YYm= NVTjbHNVOjRiaB?= NHXpdJpKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36gbY4hcHWvYX6gRnYzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDHdolme3NiYYPzZZktKEmFNUC9OE4{KM7:TR?= NYLvZnh1OjVzMkexOlQ>
human HTLA cells MnfsSpVv[3Srb36gZZN{[Xl? NV65SHZrOjBibXnudy=> M1nqeGlvcGmkaYTpc44hd2ZiQ2izR2wyNXO2aX31cIF1\WRiQ2izR3IyKGmwIHj1cYFvKEiWTFGgZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMkCgcYlveyCvZXHzeZJm\CCxbjDkZZkhPCCkeTDi[ZRiKGG{cnXzeIlvNXKnY4L1bZRu\W62IH3l[IlifGWmIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME20MlUh|ryP NUTYS|hVOjN2M{e3O|I>
human LOXIMVI cells M3Tic2Z2dmO2aX;uJIF{e2G7 M{PnZmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMU3hKVV[LIHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD12Lk[1JO69VQ>? NU\B[W1mOjVzM{m1Olk>
Jurkat T cells MV\GeY5kfGmxbjDhd5NigQ>? NW\CV2R5SWO2aY\peJkh[WejaX7zeEBpgWS{b3flckBx\XKxeHnk[UBqdmS3Y3XkJGRPSSCmYX3h[4UhcW5iSoXyb4F1KFRiY3XscJMtKEmFNUC9OUDPxE1? Ml;yNVY{QTJ6MUS=
human HCT116 cells NH33[YFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfSNoQ1QCCq NEDZOVVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNib4\ldoV5eHKnc4PpcochWEl|S3HsdIhiKEhzMES3VkBufXSjboSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13Lkeg{txO NIL3TVEzOjJzMkeyNS=>
human NCI-H522 cells NYDM[oxGTnWwY4Tpc44h[XO|YYm= NV\WPJp7SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNUKyJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME21Mlc4KM7:TR?= MXWyOVE{QTV4OR?=
human U2OS cells MkHMSpVv[3Srb36gZZN{[Xl? NG\vNYdC\2:waYP0JIFkfGm4aYT5JIF1KEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJHUzV1NiY3XscJMh[2:neIDy[ZN{cW6pIFfhcFQuXlBzNj3USXYh[XO|ZYPz[YQh[XNiYnX0ZUBienKnc4TpckB1emGwc3zvZ4F1cW:wIHHmeIVzKDViaILzJIJ6KGKndHGgcIFkfGGvYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OU46OyEQvF2= MnTGNlQ6ODB2NEe=
human NCI-H157 cells NVTnfG46TnWwY4Tpc44h[XO|YYm= NVP0OnV7SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUW3JINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME22JO69VQ>? MXiyOVE{QTV4OR?=
human A549 cells MVLGeY5kfGmxbjDhd5NigQ>? NIi3cJFCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:Pi5{IN88US=> MlryNlUyOzl3Nkm=
human HCT116 cells MkGwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGL0Too1QCCq NF;LRoFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjdizszN MoLXNlIzOTJ5MkG=
MDCK cells NXfhSVhTTnWwY4Tpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD14Lkmg{txO NUP5eZpLOjF|NUS4NFA>
human HOP62 cells M4fSOmZ2dmO2aX;uJIF{e2G7 M3jZ[mFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIU3A3OiClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:Py53MjFOwG0> M{X6W|I2OTN7NU[5
human H460 cells M3LQcmZ2dmO2aX;uJIF{e2G7 M2jUWmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIJ6KEiWUzDhd5NigSxiSVO1NF06NjZ{IN88US=> NEXiVmwzPTF|OUW2PS=>
human BV2 cells MWnGeY5kfGmxbjDhd5NigQ>? NYrFXIdQSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBDXjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBjgSCJcnnld5Mh[XO|YYmsJGlEPTB;MUCg{txO NXraSJpZOjR5MEe5N|g>
human MCF7 cells M4eyVGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXW3NkBp NXPCWohnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvQSEQvF2= MmjONlU6ODZ|OEW=
human 2008 cells NUTZcnJlS3m2b4TvfIlkcXS7IHHzd4F6 MUK3NkBp M3vJN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFIxODhiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKxMlE5KM7:TR?= NIf6TnczPTlyNkO4OS=>
human A431 cells NH\uXIZEgXSxdH;4bYNqfHliYYPzZZk> NX3SN2tbPzJiaB?= NHLQdYhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yN{4xPCEQvF2= NFniVXkzPTlyNkO4OS=>
human BxPC3 cells MUPDfZRwfG:6aXPpeJkh[XO|YYm= Mn\hO|IhcA>? MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCfHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkSuNVIh|ryP MkLoNlU6ODZ|OEW=
human HepG2 cells NVjQfGoyS3m2b4TvfIlkcXS7IHHzd4F6 NInXW4NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;M{CuPUDPxE1? MV[yNVczPjB5Nx?=
human MDA-MB-231 cells MoOxSpVv[3Srb36gZZN{[Xl? M3[5VVIxKM7:TR?= NXeyOXJDOTJiaB?= NVTrNXBGUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINt\WG4ZXSgZ4F{eGG|ZT23JIFk[3WvdXzheIlwdiCjdDCyNEB2VSCjZoTldkAyOiCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NHnoN3ozOTZ3MkKwPC=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

27175602 18655187
Growth inhibition assay
Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

27175602 28280414
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04474626 Not yet recruiting Drug: Isoquercetin Sickle Cell Disease|Sickle Cell-Beta0-Thalassemia Jeffrey Zwicker MD|Quercegen Pharmaceuticals|Dana-Farber Cancer Institute September 2020 Phase 2
NCT04063124 Recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID