Quercetin

For research use only.

Catalog No.S2391 Synonyms: Sophoretin

5 publications

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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Selleck's Quercetin has been cited by 5 publications

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells M13sPGZ2dmO2aX;uJIF{e2G7 M364XmlvcGmkaYTpc44hd2ZicnH0JIVkfG9vNTetcpVkdGWxdHnkZZNmKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZpkh[2GyaXzsZZJ6KGWuZXP0do9xcG:{ZYPpd{Bu\XSqb3SsJGtqRTR3LkOgcm0> NWLvWWszOjBzNE[0PFM>
RBL-1 cells MVrGeY5kfGmxbjDhd5NigQ>? NVj6PZBKUW5idnn0do8hcW6qaXLpeIlwdiCjZ3HpcpN1KDVvbHnwc5h6\2WwYYPlJIlvKFKETD2xJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVAvOiEQvF2= MkTQPFI2PDZ{MB?=
HEK293 FS cells NYXPd2k3TnWwY4Tpc44h[XO|YYm= NGLiVoZKdmirYnn0bY9vKG:oIF7PXFQh\XiycnXzd4VlKGmwIFjFT|I6OyCIUzDj[YxteyCjc4Pld5Nm\CCjczDINm8zKHC{b3T1Z5Rqd25iYomgTFJQOi:WeYKvUHBQKGG|c3H5MEBKSzVyPUCuOlgh|ryP NEPxeXozODd|MUO1Oy=>
RAW264.7 cells NV\ibXl3TnWwY4Tpc44h[XO|YYm= NYqxeIljOjRiaB?= Mkm1TY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIFnfGW{IEK0JIhzeyxiSVO1NF0yNjNizszN M37XW|I{PTRyOUix
human HeLa cells MXnGeY5kfGmxbjDhd5NigQ>? M3HYW2lvcGmkaYTpc44hd2ZiTWLQNUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{PIYWxVSzRidILhcpNxd3K2IHL5JJJieGmmIH\pcJRz[XSrb36gZZN{[XluIFvpQVIvPCEQvF2= NIP5dFEyQTd{NUW3PC=>
HT22 cells M1;5Z2Z2dmO2aX;uJIF{e2G7 NFXYOJRKdmirYnn0bY9vKG:oIHfseZRidWG2ZT3pcoR2[2WmIH;4fZRwe2m|IH;mJI1wfXOnIHjpdJBw[2GvcHHsJGhVOjJiY3XscJMtKEWFNUC9Nk46QCEQvF2= MoG5NVY{QTJ6MUS=
HT22 cells NF72RYdHfW6ldHnvckBie3OjeR?= MXTO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP NVLydIxDOjR4MEK5NFQ>
NCI-H1792 cells NUfY[2ZuTnWwY4Tpc44h[XO|YYm= NGfXbmhCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzN{myJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME2zMlg2KM7:TR?= NU\w[W5{OjVzM{m1Olk>
human BV2 cells NXXQbXE4TnWwY4Tpc44h[XO|YYm= MmDPNlQhcA>? M{D5RWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjDpckBpfW2jbjDCWlIh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME20MlMh|ryP MYGyOVEzPzF4NB?=
human HTLA cells NWTKNWRuTnWwY4Tpc44h[XO|YYm= MmXiNlAhdWmwcx?= NVjhZ2lvUW6qaXLpeIlwdiCxZjDDXFNEVDFvc4TpcZVt[XSnZDDDXFNEWjFiaX6gbJVu[W5iSGTMRUBk\WyuczDwdoUucW6ldXLheIVlKG[xcjCyNEBucW6|IH3lZZN2emWmIH;uJIRigSB2IHL5JIJmfGFiYYLy[ZN1cW5vcnXjdpVqfG2nboSgcYVlcWG2ZXSgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVQvPSEQvF2= M3TZd|I{PDN5N{ey
human LOXIMVI cells MX7GeY5kfGmxbjDhd5NigQ>? NWH4dFk2SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGxQYEmPVlmgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUSuOlUh|ryP NIfLOogzPTF|OUW2PS=>
Jurkat T cells NYPMUm1STnWwY4Tpc44h[XO|YYm= M1G0fWFkfGm4aYT5JIFo[Wmwc4SgbJllem:pZX6gdIVzd3irZHWgbY5lfWOnZDDEUmEh\GGvYXflJIlvKEq3cnvheEBVKGOnbHzzMEBKSzVyPUWg{txO NEPHPFIyPjN7MkixOC=>
human HCT116 cells NVexbG9GT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NY\zeVJwPDhiaB?= Mn3GS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHBKO0ujbIDoZUBJOTB2N2KgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS55IN88US=> MmTiNlIzOTJ5MkG=
human NCI-H522 cells NV;tToNzTnWwY4Tpc44h[XO|YYm= NW[3NVFKSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNUKyJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME21Mlc4KM7:TR?= M2nTc|I2OTN7NU[5
human U2OS cells M4\HdmZ2dmO2aX;uJIF{e2G7 M3TDd2Fod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gWVJQWyClZXzsd{Bkd2W6cILld5NqdmdiR3HsOE1XWDF4LWTFWkBie3Onc4Pl[EBieyCkZYThJIFzemW|dHnuJJRz[W6|bH;jZZRqd25iYX\0[ZIhPSCqcoOgZpkh[mW2YTDsZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME21Mlk{KM7:TR?= NILjeIQzPDlyMES0Oy=>
human NCI-H157 cells M3[yZWZ2dmO2aX;uJIF{e2G7 NV\RVIdJSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUW3JINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME22JO69VQ>? M3zqSFI2OTN7NU[5
human A549 cells MVHGeY5kfGmxbjDhd5NigQ>? NYfZOYtqSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTZwMjFOwG0> M1Xsb|I2OTN7NU[5
human HCT116 cells NHnkXYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3iySlQ5KGh? MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22Mlch|ryP M{HkNFIzOjF{N{Kx
MDCK cells MWrGeY5kfGmxbjDhd5NigQ>? NF:0WI5KdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP NVnQOlVyOjF|NUS4NFA>
human HOP62 cells MluzSpVv[3Srb36gZZN{[Xl? M4\uTGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIU3A3OiClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:Py53MjFOwG0> M1i4WFI2OTN7NU[5
human H460 cells MmmwSpVv[3Srb36gZZN{[Xl? NFfvZYZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:QS54MjFOwG0> NXzzenBiOjVzM{m1Olk>
human BV2 cells M1\3OGZ2dmO2aX;uJIF{e2G7 NXXMdFNISW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBDXjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBjgSCJcnnld5Mh[XO|YYmsJGlEPTB;MUCg{txO M3;J[|I1PzB5OUO4
human MCF7 cells MnLaR5l1d3SxeHnjbZR6KGG|c3H5 MWG3NkBp NITGV|lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNE46KM7:TR?= NVvZWXg4OjV7ME[zPFU>
human 2008 cells MmjYR5l1d3SxeHnjbZR6KGG|c3H5 NEjpWmY4OiCq MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyNFA5KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{MT6xPEDPxE1? Mo\vNlU6ODZ|OEW=
human A431 cells NUf4Wm1mS3m2b4TvfIlkcXS7IHHzd4F6 NXLxNmNlPzJiaB?= MnvpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkOuNFQh|ryP MVyyOVkxPjN6NR?=
human BxPC3 cells NF;CfGhEgXSxdH;4bYNqfHliYYPzZZk> M3LkT|czKGh? MnjBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUK0MlEzKM7:TR?= M3zCcFI2QTB4M{i1
human HepG2 cells Ml\oR5l1d3SxeHnjbZR6KGG|c3H5 M3zDbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65JO69VQ>? M2jxZ|IyPzJ4MEe3
human MDA-MB-231 cells NHTjbFZHfW6ldHnvckBie3OjeR?= M3rJTVIxKM7:TR?= MX2xNkBp NGTGZWtKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4xm[X[nZDDjZZNx[XOnLUegZYNkfW23bHH0bY9vKGG2IEKwJJVOKGGodHXyJFEzKGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NXLtdHcxOjF4NUKyNFg>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

27175602 18655187
Growth inhibition assay
Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

27175602 28280414
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin
Smiles OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Suspended Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID