Quercetin (NSC 9221)

Catalog No.S2391 Synonyms: Sophoretin, C.I. 75720

For research use only.

Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

Quercetin (NSC 9221) Chemical Structure

CAS No. 117-39-5

Selleck's Quercetin (NSC 9221) has been cited by 26 publications

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Biological Activity

Description Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
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2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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ANN-1 NYTqSWh6S3m2b4TvfIlkcXS7IHHzd4F6 NULlPZF3S3m2b4TvfIlkKGWoZnXjeEBwdiC4LXHicEB1emGwc3\vdo1m\CCvdYLpcoUhSU6QLUGgZ4VtdHNuIFnDOVA:OzJwNd88US=> NV70Xm46RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEKwNVYxOyd-OEKwNVYxOzxxYU6=
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MCF-7 MX M3HaTmZ2dmO2aX;uJIF{e2G7 Ml3RTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPQ1[tO{BOYCClZXzsd{B2e2mwZzDIc4VkcHO2IEOzN|QzKHO2YXnubY5oNCCLQ{WwQVcvPs7:TR?= NVfHfJY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVQ5ODBpPkKxN|U1QDByPD;hQi=>
HepG2(2.2.15) NGXXUlFEgXSxdH;4bYNqfHliYYPzZZk> MVu4JIRigXN? M1;4fGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[W[2ZYKgPEBl[Xm|IHL5JG1VXCCjc4PhfUwhS0N3ME2zPE4y|ryP M{TNSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNECxNVE2Lz5{MUSwNVEyPTxxYU6=
MDA-MB-231 NXGxe|ZJTnWwY4Tpc44h[XO|YYm= MWeyNEB2VQ>? NVf3OpVCOzBibXnudy=> MXTJcoNz\WG|ZTDpckBkNU[xczDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDheEAzOCC3TTD3bZRpcW5iM{CgcYlveyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NX;5S|lTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OVIzODhpPkKxOlUzOjB6PD;hQi=>
MDA-MB-231 MWrGeY5kfGmxbjDhd5NigQ>? MXOyNEB2VQ>? M3HVflMxKG2rboO= NIHEenhKdmO{ZXHz[UBqdiCHZ4KtNUBxem:2ZXnuJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BifCB{MDD1UUB4cXSqaX6gN|AhdWmwczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ3MkKwPEc,OjF4NUKyNFg9N2F-
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HepG2 M{n3UmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{TSVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65{txO M2G4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{K2NFc4Lz5{MUeyOlA4PzxxYU6=
Jurkat MkfjSpVv[3Srb36gZZN{[Xl? NH3pXmwyPDVidV2= M332UVghcHK| NFTOeoJKdmirYnn0bY9vKG:oIHjlZZQhe2ixY3utbY5lfWOnZDDIV3A4OCCneIDy[ZN{cW:wIHnuJIh2dWGwIFr1dotifCClZXzsd{BifCBzNEWgeW0hfHKnYYTl[EAzKGi{czDi[YZwemViYnXheEB{cG:lazDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiODDodpMh[nliV3XzeIVzdiCkbH;0eIlv\w>? M4nkbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{m4O|Q5Lz5{MUe5PFc1QDxxYU6=
HepG2 MkfSSpVv[3Srb36gZZN{[Xl? M{XJfVI1KGi{cx?= NXLkfYxHUW6qaXLpeIlwdiCxZjDvcIVq[yCjY3nkMYlv\HWlZXSgeJJq\2y7Y3XybYRmKG:4ZYKtZYNkfW23bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9tNCCLQ{OwQVE1NjoQvF2= NXrwfYFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NlQ3QTBpPkKxPFI1PjlyPD;hQi=>
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MDCK NYjTXZV[SW62aY\pdoFtKGG|c3H5 MUm0JIRigXN? NV7TPW9mSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhMEFxc4fpcoUwV0hxNUGxOFQ2NzJyMEeoTFFPOSlrIF;oO{Bqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPCCmYYnzJIJ6KHG3YX70bZRifGm4ZTDSWE1RS1JuIFXEOVA:PDhwMt88US=> MoLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUW1PVEoRjJ{MUG1OVkyRC:jPh?=
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HCT116 NVz1WGlmTnWwY4Tpc44h[XO|YYm= NX3qS4F3OjVidV2= MYnJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDheEAzPSC3TTDifUBqdW23bn;icI91KGGwYXz5d4l{ NUHlOYpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
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PC12 NGXhbFdP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? M{\NOFExKHWP NVjmV3AyOyCqcoO= M2OzNm5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBz[XRiUFOxNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5QhUDKRMj3pcoR2[2WmIHP5eI91d3irY3n0fUBifCBzMDD1UUBxemVvaX7jeYJifGWmIH\vdkA{KGi{czDi[YZwemViSELPNkBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOTJiaILzJIJ6KE2WVDDhd5NigQ>? NUewbVJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlg6QTBpPkOxNVI5QTlyPD;hQi=>
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Assay
Methods Test Index PMID
Western blot Her-2 / p-PI3K / p-Akt / Akt ; p-JAK1 / p-STAT3 / STAT3 / VEGF ; p-p53 / p53 / p21 ; Bcl-2 / Bax / Bcl-xl 18655187 27175602
Growth inhibition assay Cell viability ; Cell viability 28280414 27175602
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

6mg/mL

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907253 Recruiting Drug: Quercetin|Drug: Placebo Coronary Artery Disease Montreal Heart Institute June 4 2021 Phase 2
NCT04474626 Withdrawn Drug: Isoquercetin Sickle Cell Disease|Sickle Cell-Beta0-Thalassemia Jeffrey Zwicker MD|Quercegen Pharmaceuticals|Dana-Farber Cancer Institute December 2020 Phase 2
NCT04063124 Active not recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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