Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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Cited by 3 Publications

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells MkfySpVv[3Srb36gZZN{[Xl? NE[xW4VKdmirYnn0bY9vKG:oIILheEBm[3SxLUWnMY52[2ynb4Tp[IF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIJ6KGOjcHnscIFzgSCnbHXjeJJweGixcnXzbZMhdWW2aH;kMEBMcT12NT6zJI5O M2TZV|IxOTR4NEiz
RBL-1 cells MYXGeY5kfGmxbjDhd5NigQ>? NHTiXHRKdiC4aYTyc{BqdmirYnn0bY9vKGGpYXnud5QhPS2uaYDvfJlo\W6jc3WgbY4hWkKOLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQtKEmFNUC9NE4zKM7:TR?= M3fnelgzPTR4MkC=
HEK293 FS cells MVTGeY5kfGmxbjDhd5NigQ>? Ml\VTY5pcWKrdHnvckBw\iCQT2i0JIV5eHKnc4Pl[EBqdiCKRVuyPVMhTlNiY3XscJMh[XO|ZYPz[YQh[XNiSELPNkBxem:mdXP0bY9vKGK7IFiyU|IwXHm{L1zQU{Bie3OjeTygTWM2OD1yLk[4JO69VQ>? MYKyNFc{OTN3Nx?=
RAW264.7 cells NYS0WJhITnWwY4Tpc44h[XO|YYm= NEHON3EzPCCq M3juVmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OS5|IN88US=> MmrxNlM2PDB7OEG=
human HeLa cells NH3IT2RHfW6ldHnvckBie3OjeR?= NVnnTIw1UW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> M3jl[lE6PzJ3NUe4
HT22 cells NXS3follTnWwY4Tpc44h[XO|YYm= M1vpPGlvcGmkaYTpc44hd2ZiZ3z1eIFu[XSnLXnu[JVk\WRib4j5eI9{cXNib3[gcY92e2ViaHnwdI9k[W2yYXygTHQzOiClZXzsd{whTUN3ME2yMlk5KM7:TR?= MnHDNVY{QTJ6MUS=
HT22 cells M3LsRmZ2dmO2aX;uJIF{e2G7 MXPO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP NFm2VpgzPDZyMkmwOC=>
NCI-H1792 cells MkOzSpVv[3Srb36gZZN{[Xl? M2T2SWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF5OUKgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUOuPFUh|ryP MV2yOVE{QTV4OR?=
human BV2 cells MXXGeY5kfGmxbjDhd5NigQ>? Mo\zNlQhcA>? MV7Jcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25iaX6gbJVu[W5iQm[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;ND6zJO69VQ>? MVmyOVEzPzF4NB?=
human HTLA cells NUnV[oc2TnWwY4Tpc44h[XO|YYm= MkLyNlAhdWmwcx?= M{e5TGlvcGmkaYTpc44hd2ZiQ2izR2wyNXO2aX31cIF1\WRiQ2izR3IyKGmwIHj1cYFvKEiWTFGgZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMkCgcYlveyCvZXHzeZJm\CCxbjDkZZkhPCCkeTDi[ZRiKGG{cnXzeIlvNXKnY4L1bZRu\W62IH3l[IlifGWmIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME20MlUh|ryP Mke2NlM1Ozd5N{K=
human LOXIMVI cells NEnEOFZHfW6ldHnvckBie3OjeR?= MoLjRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTRwNkWg{txO NYK5SXFsOjVzM{m1Olk>
Jurkat T cells MoDjSpVv[3Srb36gZZN{[Xl? NY\zSI1MSWO2aY\peJkh[WejaX7zeEBpgWS{b3flckBx\XKxeHnk[UBqdmS3Y3XkJGRPSSCmYX3h[4UhcW5iSoXyb4F1KFRiY3XscJMtKEmFNUC9OUDPxE1? NFrJRlYyPjN7MkixOC=>
human HCT116 cells MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnSVFZrPDhiaB?= MkHvS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHBKO0ujbIDoZUBJOTB2N2KgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS55IN88US=> NXPoOGVGOjJ{MUK3NlE>
human NCI-H522 cells M{XWbmZ2dmO2aX;uJIF{e2G7 MoPaRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPTJ{IHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD13Lke3JO69VQ>? MlriNlUyOzl3Nkm=
human U2OS cells MlLqSpVv[3Srb36gZZN{[Xl? MmPIRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWFJ|NTDy[YNmeHSxcjDpckBpfW2jbjDVNm9UKGOnbHzzJINw\XiycnXzd4lv\yCJYXy0MXZROTZvVFXWJIF{e2W|c3XkJIF{KGKndHGgZZJz\XO2aX6geJJidnOub3PheIlwdiCjZoTldkA2KGi{czDifUBj\XSjIHzhZ5RidWG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUWuPVMh|ryP NHrMWI0zPDlyMES0Oy=>
human NCI-H157 cells NGT4V41HfW6ldHnvckBie3OjeR?= MUXBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPTdiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTZizszN MUmyOVE{QTV4OR?=
human A549 cells MYnGeY5kfGmxbjDhd5NigQ>? MoLYRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVYvOiEQvF2= M1LLOlI2OTN7NU[5
human HCT116 cells M33Ecmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFvrPIg1QCCq MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22Mlch|ryP M{fCflIzOjF{N{Kx
MDCK cells NHHU[2NHfW6ldHnvckBie3OjeR?= NHfuXGNKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP NX3jU2FjOjF|NUS4NFA>
human HOP62 cells NXv5TW9YTnWwY4Tpc44h[XO|YYm= MWfBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF;QOlIh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVcvPTJizszN MXSyOVE{QTV4OR?=
human H460 cells NYTDdHo4TnWwY4Tpc44h[XO|YYm= NWfx[IxkSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTlwNkKg{txO NE\Bd20zPTF|OUW2PS=>
human BV2 cells M3TDdGZ2dmO2aX;uJIF{e2G7 MXHBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFLWNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHL5JGdzcWW|czDhd5NigSxiSVO1NF0yOCEQvF2= M{DHTFI1PzB5OUO4
human MCF7 cells M{jmc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MX[3NkBp Mki2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkCuPUDPxE1? MmXVNlU6ODZ|OEW=
human 2008 cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= NHrNOYw4OiCq NUDtNZg2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOjByODDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlEvOThizszN NILRTnkzPTlyNkO4OS=>
human A431 cells MVfDfZRwfG:6aXPpeJkh[XO|YYm= MmrkO|IhcA>? MmHqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkOuNFQh|ryP NVy1cFBCOjV7ME[zPFU>
human BxPC3 cells NUXoR3pLS3m2b4TvfIlkcXS7IHHzd4F6 M4XYNVczKGh? NF;SUndEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlQvOTJizszN NYjrVJRiOjV7ME[zPFU>
human HepG2 cells NUC3RopSS3m2b4TvfIlkcXS7IHHzd4F6 MkTZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTNyLkmg{txO NW\SbnpLOjF5Mk[wO|c>
human MDA-MB-231 cells MXHGeY5kfGmxbjDhd5NigQ>? NFXrd3UzOCEQvF2= NGjIfm0yOiCq M4XwPWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M4DsfFIyPjV{MkC4

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin

Bio Calculators

Molarity Calculator

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04063124 Not yet recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic December 2019 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID