Quercetin (NSC 9221)

For research use only.

Catalog No.S2391 Synonyms: Sophoretin, C.I. 75720

21 publications

Quercetin (NSC 9221) Chemical Structure

CAS No. 117-39-5

Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

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Selleck's Quercetin (NSC 9221) has been cited by 21 publications

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Choose Selective Sirtuin Inhibitors

Biological Activity

Description Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Walker 256 NUDmeY1{SW62aYT1cY9zKGG|c3H5 M1jtNmlvKH[rdn:gZY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgdoF1KFejbHvldkAzPTZiY3XscJM> M4jrRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzR4OUW1OEc,PDZ7NUW0QE9iRg>?
RBI-1 M37WbGZ2dmO2aX;uJIF{e2G7 MnTBTY4hfmm2cn:gbY5pcWKrdHnvckBw\iB3LXzpdI95gWenbnHz[UApPS2ubzmg[pJwdSC2aHWgNlAxODBiZzDzeZBmem6jdHHueEBw\iCUQlmtNUBk\WyuczygTWM2OD1yLkROwG0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ4OUi5K|4zODZ4OUi5QE9iRg>?
MCF-7 M4HnZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWDJeHZRS3m2b4TvfIlkKGWoZnXjeEBwdiCPQ1[tO{BpfW2jbjDidoVie3RiY3HyZ4lvd22jIHPlcIx{NCCLQ{WwQVI1|ryP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85OjBzNkCzK|45OjBzNkCzQE9iRg>?
ANN-1 M3TJNWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2PxUWN6fG:2b4jpZ{Bm\m[nY4Sgc44hfi2jYnygeJJidnOob4Lt[YQhdXW{aX7lJGFPVi1zIHPlcIx{NCCLQ{WwQVMzNjYQvF2= M3rCWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh{MEG2NFMoRjh{MEG2NFM9N2F-
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WiDr human colon cells NU\EfpVnS3m2b4TvfIlkcXS7IHHzd4F6 MmrtR5l1d3SxeHnjJIVn\mWldDDvckBYcUS{IHj1cYFvKGOxbH;uJINmdGy|LDDJR|UxRTRyLkNOwG0> MnLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDJyMU[wN{c,QDJyMU[wN|ww[T5?
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HepG2(2.2.15) MV7DfZRwfG:6aXPpeJkh[XO|YYm= NV3lNY5MQCCmYYnz NEHjT|VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGGodHXyJFgh\GG7czDifUBOXFRiYYPzZZktKEOFNUC9N|gvOc7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRyMUGxOUc,OjF2MEGxNVU9N2F-
MDA-MB-231 NVnC[nVCTnWwY4Tpc44h[XO|YYm= M4TXb|IxKHWP NELoXlI{OCCvaX7z MVPJcoNz\WG|ZTDpckBkNU[xczDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDheEAzOCC3TTD3bZRpcW5iM{CgcYlveyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> M3\oZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkWyNlA5Lz5{MU[1NlIxQDxxYU6=
MDA-MB-231 MmS3SpVv[3Srb36gZZN{[Xl? NVfIdoZWOjBidV2= NFq0bpg{OCCvaX7z NHHqV3VKdmO{ZXHz[UBqdiCHZ4KtNUBxem:2ZXnuJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BifCB{MDD1UUB4cXSqaX6gN|AhdWmwczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NHL4WIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[1NlIxQCd-MkG2OVIzODh:L3G+
MDA-MB-231 MnXIRZBweHSxc3nzJIF{e2G7 MlPINlAhfU1? M17VbFEzKGi{cx?= M1LPOGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MlHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NUKyNFgoRjJzNkWyNlA5RC:jPh?=
HepG2 MY\DfZRwfG:6aXPpeJkh[XO|YYm= M13zS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65{txO MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd{NkC3O{c,OjF5Mk[wO|c9N2F-
Jurkat MWnGeY5kfGmxbjDhd5NigQ>? M1rOd|E1PSC3TR?= Mo\WPEBpenN? NV\lSm8yUW6qaXLpeIlwdiCxZjDo[YF1KHOqb3PrMYlv\HWlZXSgTHNRPzBiZYjwdoV{e2mxbjDpckBpfW2jbjDKeZJs[XRiY3XscJMh[XRiMUS1JJVOKHS{ZXH0[YQhOiCqcoOgZoVnd3KnIHLlZZQhe2ixY3ugZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEigbJJ{KGK7IGfld5Rmem5iYnzveJRqdmd? MmTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OUi3OFgoRjJzN{m4O|Q5RC:jPh?=
HepG2 M164V2Z2dmO2aX;uJIF{e2G7 MXuyOEBpenN? M2rnPWlvcGmkaYTpc44hd2Zib3zlbYMh[WOrZD3pcoR2[2WmIITybYdtgWOncnnk[UBwfmW{LXHjZ5VufWyjdHnvckBqdiCqdX3hckBJ\XCJMjDj[YxteyCrbnP1ZoF1\WRiZn;yJFI1KGi{czDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcEwhUUN|ME2xOE46|ryP NXTmXHVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NlQ3QTBpPkKxPFI1PjlyPD;hQi=>
HepG2 NXTmNXFXSW62aX;4bYRidnRiYYPzZZk> NF2yd|MzPCCqcoO= NEDxWI9CdnSrb4jp[IFvfCCjY4Tpeol1gSCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2Zib3zlbYMh[WOrZD3pcoR2[2WmIGLPV{Bo\W6ncnH0bY9vKGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JGRJS0ZvRFGgZoF{\WRiZnz1c5JqdWW2cnnjJIF{e2G7IILlcIF1cX[nIITvJJVvfHKnYYTl[EBkd262cn;sMEBKSzNyPUOwMljPxE1? Mnr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MkS2PVAoRjJzOEK0OlkxRC:jPh?=
MDCK NYrrW4Z7SW62aY\pdoFtKGG|c3H5 NYrMfoRxPCCmYYnz NF3MeXNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBqdm[udXXufoEhSSC4aYL1d{ApSS:|d3nu[U9QUC93MUG0OFUwOjByNzjINW4yMSliT3i3JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA1KGSjeYOgZpkheXWjboTpeIF1cX[nIGLUMXBEWixiRVS1NF01QC5{zszN MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzNUW5NUc,OjJzMUW1PVE9N2F-
HCT116 NEX5NoVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWric3U2PDhiaILz NWD2bZdOT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT63{txO M3\1S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkGyO|IyLz5{MkKxNlczOTxxYU6=
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HCT116 MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPUU2s1QCCqcoO= MYrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMhd3[ncnX4dJJme3OrbnegVGk{U2GucHjhJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkROwG0> MkXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
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HCT116 NX\Pe3p5TnWwY4Tpc44h[XO|YYm= NH2yUmszPSC3TR?= NYXaUGNGOTBibXnudy=> NYLDUIcyUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgTFExPDeUIH31eIFvfCCrbjDoeY1idiCKQ2SxNVYh[2WubIOgeZNqdmdiW{OyVH1CXFBiYYSgNlUhfU1iYX\0[ZIhOTBibXnudy=> NXO0ZlhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
HCT116 NFLuOYtHfW6ldHnvckBie3OjeR?= NUTzcmpUOjVidV2= NV\PflRjUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSWu2IGPldlQ4OyCyaH;zdIhwenmuYYTpc44h[XRiMkWgeW0h[nliaX3teY5w[myxdDDhcoFtgXOrcx?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJzMkeyNUc,OjJ{MUK3NlE9N2F-
HCT116 MlHLSpVv[3Srb36gZZN{[Xl? NEj3U24zPSC3TR?= NWTvOYNvUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgTFExPDeUIH31eIFvfCCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDheEAzPSC3TTDifUBqdW23bn;icI91KGGwYXz5d4l{ NEPlWpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKxNlczOSd-MkKyNVI4OjF:L3G+
human mast cells MnX2SpVv[3Srb36gZZN{[Xl? MmXVTY5pcWKrdHnvckBw\iCVWVugbY4hcHWvYX6gcYF{fCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gcYF{fCClZXzsJIRm\3KjboXsZZRqd25uIFXDOVA:OzYQvF2= NYrkV5M3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOVczOTNpPkKyNlU4OjF|PD;hQi=>
Huh7.5.1 NGjLTFVCdnSrdnnyZYwh[XO|YYm= MV:3NkBpenN? MlLNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNXKEqISD2xJGo{QTmHTTDpcoZm[3SnZDDpckBJfW2jbjDIeYg4NjVwMTDj[YxteyCjc4Pld5Nm\CCjczDzeZBxemW|c3nvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOgZpkhTUeIUDDhd5NigSxiRVO1NF0yQS56zszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NUOyPEc,OjJ2NEWzNlg9N2F-
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RAW264.7 NVXSUZBvTnWwY4Tpc44h[XO|YYm= M3vRd|UxKHWP MYGzJIhzew>? MnrpRYN1cX[jdHnvckBw\iCQcn[yJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIN6fG:|b3zpZ{Bi[2O3bYXsZZRqd25iYYSgOVAhfU1iYX\0[ZIhOyCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> NHvTTmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K5OFI5Pid-MkOyPVQzQDZ:L3G+
RAW264.7 NIPBfmJHfW6ldHnvckBie3OjeR?= NUjVPJhqPTBidV2= Mn3mN{BpenN? MXzBZ5RqfmG2aX;uJI9nKE6{ZkKgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgcpVkdGWjcjDhZ4N2dXWuYYTpc44h[XRiNUCgeW0h[W[2ZYKgN{BpenNiYomgW4V{fGW{bjDicI91fGmwZzDhcoFtgXOrcx?= NYD0PJhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyPVQzQDZpPkKzNlk1Ojh4PD;hQi=>
ARPE19 NVH3bpAyTnWwY4Tpc44h[XO|YYm= NYfOTIRrOjBidV2= NFniSpAyQCCmYYnz MkTkTY5pcWKrdHnvckBw\iCrboTyZYNmdGy3bHHyJGEzTSCyaH;0c495cWSjdHnvckBqdiCqdX3hckBCWlCHMUmgZ4VtdHNiYYSgNlAhfU1iYX\0[ZIhOThiZHH5dy=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN2Nki2Okc,OjN|NE[4OlY9N2F-
MV4-11 MXrDfZRwfG:6aXPpeJkh[XO|YYm= Mk\WO|IhcHK| MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhcGG{Yn;ybY5oKE[OVEOgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IITleJJigm:uaYXtJIJie2WmIFX6JGN6XG:6IHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBIUTVyPUGzMlHPxE1? MmnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUGwO|MoRjJ|NEGxNFc{RC:jPh?=
RS4:11 M{j4SGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFnuTYw4OiCqcoO= M3HxXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJUPDpzMTDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIF\MWFMh[W[2ZYKgO|IhcHK|IHL5JJRmfHKjen;sbZVuKGKjc3XkJGV7KEO7VH;4JINmdGxidnnhZoltcXS7IHHzd4F6NCCJSUWwQVIyNjcQvF2= MmXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUGwO|MoRjJ|NEGxNFc{RC:jPh?=
HCT116 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NUHOb|V{OSC2bzCxNFAhfU1? NH;VOpMyOiCqcoO= M3TCZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjdDCxJJRwKDFyMDD1UUBi\nSncjCxNkBpenNiYomgUXRVKGG|c3H5 NXPsXXRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0N|QyOzJpPkKzOFM1OTN{PD;hQi=>
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PC12 NHrZOGJP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? MnLnNVAhfU1? MlnXN{BpenN? NF\aVI1P\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hemG2IGDDNVIh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KEh{T{KtbY5lfWOnZDDjfZRwfG:6aXPpeJkh[XRiMUCgeW0heHKnLXnuZ5Vj[XSnZDDmc5IhOyCqcoOgZoVnd3KnIFiyU|Ih[WSmaYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDF{IHjyd{BjgSCPVGSgZZN{[Xl? M1L0S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK4PVkxLz5|MUGyPFk6ODxxYU6=
SH-SY5Y NHPZeohP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? MoS5NVAxKHWP NGHlfHIyKGi{ NFvme3RP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDINm8zNWmwZIXj[YQhd3irZHH0bZZmKHO2cnXzd{BqdiCqdX3hckBUUC2VWUXZJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCUT2Og[4Vv\XKjdHnvckBifCBzMECgeW0heHKnaX7jeYJifGWmIH\vdkAyKGi{IH\vcIxwf2WmIHL5JGRETkhvRFGgZYRlcXSrb36g[o9zKDNyIH3pcpMh[W6mIIP1ZpNmeXWnboSgZ48ufHKnYYTt[Y51KHerdHigZ49ueG:3bnSgZY5lKEh{T{Kg[o9zKDN? NF2yepU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUG1PFc2PCd-M{GxOVg4PTR:L3G+
HT22 NGD5ZYdP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? NIHWZoIzPSC3TR?= MoLoNlQhcHK| M3fmVG5mfXKxcILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIHPlcIwh\GWjdHigbY4hdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjdDCyOUB2VSCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6 MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZyOUGxOUc,OzF4MEmxNVU9N2F-
HT22 NWXwbnZwVmW3cn;wdo91\WO2aY\lJIF{e2G7 MUeyOUB2VQ>? MVeyOEBpenN? NFnUfmJP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZZQhdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[4x2fGGvYYTlMYlv\HWlZXSgc5hq\GG2aY\lJJN1emW|czDifUBu\WG|dYLpcoch[2WubDD2bYFjcWyrdImgZZQhOjVidV2gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliTWTUJIF{e2G7 M{jmN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNkC5OlA5Lz5|MU[wPVYxQDxxYU6=
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

18655187 27175602
Growth inhibition assay
Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

28280414 27175602
In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin, C.I. 75720
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1
NCT01720147 Recruiting Drug: Quercetin (dietary supplement) Fanconi Anemia Children''s Hospital Medical Center Cincinnati|Food and Drug Administration (FDA) July 2012 Phase 1
NCT01438320 Completed Dietary Supplement: Quercetin Chronic Hepatitis C University of California Los Angeles|American Association for Cancer Research|Tower Cancer Research Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) July 2011 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Sirtuin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID