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(-)-Epigallocatechin Gallate
Catalog No.S2250 Synonyms: EGCG
For research use only.
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
-Epigallocatechin-gallate-chemical-structure-S2250.gif)
CAS No. 989-51-5
Selleck's (-)-Epigallocatechin Gallate has been cited by 29 publications
Purity & Quality Control
Choose Selective Telomerase Inhibitors
Related Compound Libraries
Other Telomerase Products
Biological Activity
| Description | (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Targets |
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| In vitro |
(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3] |
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| Cell Data |
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| Assay |
|
Protocol (from reference)
| References |
|---|
Solubility (25°C)
|
In vitro |
Ethanol |
83 mg/mL
warmed (181.07 mM) |
| DMSO |
72 mg/mL
warmed (157.07 mM) |
|
| Water |
23 mg/mL
warmed (50.17 mM) |
Chemical Information
| Molecular Weight | 458.37 | ||
|---|---|---|---|
| Formula | C22H18O11 |
||
| CAS No. | 989-51-5 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O | ||
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT03928847 | Recruiting | Drug: Epigallocatechin-3-gallate (EGCG) | Idiopathic Pulmonary Fibrosis | Hal Chapman|National Heart Lung and Blood Institute (NHLBI)|University of California San Francisco | July 1 2018 | Early Phase 1 |
| NCT02779361 | Completed | Dietary Supplement: Green tea | Healthy Volunteers|Doping in Sports | Parc de Salut Mar|World Anti-doping Agency | January 2016 | Phase 1 |
| NCT02577393 | Enrolling by invitation | Drug: EGCG|Drug: mLDG | Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate | Shandong Cancer Hospital and Institute | April 2015 | Phase 2 |
(data from https://clinicaltrials.gov, updated on 2022-01-17)
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