(-)-Epigallocatechin Gallate
Catalog No.S2250 Synonyms: EGCG
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Molecular Weight(MW): 458.37
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
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(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.
EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate
J Cell Mol Med, 2017, 21(10):2481-2490. (-)-Epigallocatechin Gallate purchased from Selleck.
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PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.
PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.
Purity & Quality Control
Choose Selective Telomerase Inhibitors
Biological Activity
| Description | (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3] |
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| Cell Data |
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Protocol
Solubility (25°C)
| In vitro | Ethanol | 83 mg/mL warmed (181.07 mM) |
|---|---|---|
| DMSO | 72 mg/mL warmed (157.07 mM) | |
| Water | 23 mg/mL warmed (50.17 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 458.37 |
|---|---|
| Formula | C22H18O11 |
| CAS No. | 989-51-5 |
| Storage | powder |
| in solvent | |
| Synonyms | EGCG |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02891538 | Recruiting | Colon Cancer | The University of Texas Health Science Center at San Antonio | January 31 2017 | Early Phase 1 |
| NCT03624556 | Recruiting | Down Syndrome|Fragile X Syndrome | Parc de Salut Mar|Hospital Infantil Universitario Niño Jesús Madrid Spain|Instituto Hispalense de Pediatría Sevilla Spain|Hospital Universitario Marqués de Valdecilla|Institut Jerome Lejeune | January 29 2018 | Not Applicable |
| NCT02011451 | Withdrawn | Multiple Sclerosis | Louisiana State University Health Sciences Center in New Orleans|National Multiple Sclerosis Society | December 2015 | Phase 2 |
| NCT02558933 | Unknown status | Fetal Alcohol Syndrome (FAS) | Parc de Salut Mar|Fundación Mutua Madrileña | June 2015 | Phase 2|Phase 3 |
| NCT02577393 | Enrolling by invitation | Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate | Shandong Cancer Hospital and Institute | June 2015 | Phase 2 |
| NCT02580279 | Enrolling by invitation | Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate | Shandong Cancer Hospital and Institute | February 2015 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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