(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

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In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017, 21(10):2481-2490. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells NGnoWGFHfW6ldHnvckBie3OjeR?= M1fDeG5mfXKxcILveIVkfGmxbjDh[4FqdnO2IHLleIEu[W27bH;p[EBx\XC2aXTlJFEuPDJvaX7keYNm\CC2b4jpZ4l1gSCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGyjY4TheIUh\GWqeXTyc4dmdmG|ZTDy[Yxm[XOnLDDFR|UxRTBwMEO5PFch|ryP NGLIXYkyQTF|OEi1PS=>
human MDA435/LCC6MDR cells NEP2ZW5HfW6ldHnvckBie3OjeR?= Mnu0NVAh|ryP NYWyR5p{PSCmYYnz NFfOb4JOd2S3bHH0bY9vKG:oIGCt[5AhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCPRFG0N|UwVEOFNl3EVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPpZoxmKG:oIIDhZ4xqfGG6ZXygdoV{cXO2YX7j[UBu\WG|dYLl[EBieyCLQ{WwJIZweiCyYXPsbZRigGWuIHH0JFExKHWPIHHmeIVzKDViZHH5d{BjgSCFZXzsWIl1\XJiOU[gRZF2\W:3czDhd5NigSxiSVO1NF0xNjF{Mk[g{txO NVLCe5JqOjV7OEWxPVU>
Sf9 cells MkW5SpVv[3Srb36gZZN{[Xl? M17reGlvcGmkaYTpc44hd2ZiSHnzOk11[WepZXSgbJVu[W5icnXjc41jcW6jboSgSG5OXDFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFTORUBu\XSqeXz0doFve2[ncnHz[UBi[3Srdnn0fUB2e2mwZzC1K{1jcW:2aX75cIF1\WRiNEWtZpAhfW6vZYTofYxifGWmIH;yJIhmdWmvZYTofYxifGWmIH;sbYdwdnWlbHXveIll\SC|dXLzeJJifGW|IHHu[EBcO0ifLVHkc21mfCCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{Bu\XSqb3SsJGlEPTB;MD61JO69VQ>? M37pVlI2PDB4OUS0
human U937 cells Mkj3SpVv[3Srb36gZZN{[Xl? MmLETY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIGW5N|ch[2WubIOsJGlEPTB;MTFOwG0> M3\QZVIzPDF|OES1
human HeLa cells NEX1enNHfW6ldHnvckBie3OjeR?= NFvzWo5KdmirYnn0bY9vKG:oIITlcI9u\XKjc3WgbY4hcHWvYX6gTIVN[SClZXzsd{B2e2mwZzC1K{1CSVRiQ1PHJHRETyCDR1OgRWdCKEeWVD2zK{BieyC|dXLzeJJifGViaX7jeYJifGWmIH\vdkAyPSCvaX7zJJBzcW:{IITvJIV5fGWwc3nvckBz\WGldHnvckBnd2yub4fl[EBjgSClb33wc5Vv\CC5YYPoc5V1KGK7IIPwbY4ufGWub33ldolkKHKncHXheEBidXCuaX\pZ4F1cW:wIIDyc5Rw[2:uLDDJR|UxRTFwMEig{txO M{XESVIzPDF|OES1
CHO cells NEnYUYNEgXSxdH;4bYPDqGG|c3H5 MV[0PEBp M2jESGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEOKTzDj[YxteyCneIDy[ZN{cW6pIF;BWHAySjNiaHHwcI91gXCnIEGgZYZ1\XJiNEigbJJ{KGK7IH\seY9z\XOlZX7j[UBj[XOnZDDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyPUOuNkDPxE1? MWKyN|MzPzh5Nx?=
MDCK cells MmXmSpVv[3Srb36gZZN{[Xl? MYS0JIRigXN? MXTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDpcoZtfWWwenGgRUB3cXK3czCoRU9{f2mwZT;PTE82OTF2NEWvNlAxPyiKMV6xLUkhV2h5IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC0JIRigXNiYomgdZVidnSrdHH0bZZmKFKWLWDDVkwhTUR3ME24MlMh|ryP NIXNZY0zOjFzNUW5NS=>
human HL60 cells MXjQdo9tcW[ncnH0bY9vKGG|c3H5 NYrMXmt2OyCmYYnz M2nmRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB|IHThfZMtKEmFNUC9PU41KM7:TR?= NUTBfolXOTh4OUOwNlA>
HSC-T6 cells  MUTGeY5kfGmxbjDhd5NigQ>? M{f2RlQ5KGh? NULHOpZDSW62aX\pZpJwfGmlIHHjeIl3cXS7IHHnZYlve3RicnH0JGhUSy2WNjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IFLy[HUhcW6lb4Lwc5JifGmxbjDhd5NigSxiSVO1NF06NjlizszN MU[yNVUxPDh2OB?=
mouse 3T3-L1 cells NUOyVng2TnWwY4Tpc44h[XO|YYm= NG\BOI9KdmirYnn0bY9vKG:oIFe2VGQudWWmaXH0[YQhVkGGUFigdJJw\HWldHnvckBqdiCvb4Xz[UA{XDNvTEGgZ4VtdHNuIFnDOVA:OjVizszN MVSxPFMyOzNyOB?=
mouse RAW264.7 cells M2\a[2Z2dmO2aX;uJIF{e2G7 MoLUOUBl[Xm| MVnJcohq[mm2aX;uJI9nKFKDTlvMMYlv\HWlZXSgc5N1\W:lbHHzeI9o\W6nc3nzJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFSUQWCtdI9{cXSrdnWgcZVtfGlvboXjcIVifGWmIHPlcIx{KGGodHXyJFUh\GG7czygTWM2OD1{OT64JO69VQ>? M4HwclIyPDV4NUKx
HSC-T6 cells NFTGZpNRem:uaX\ldoF1cW:wIHHzd4F6 M1LSZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgdoF1KEiVQz3UOkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJktKEmFNUC9NlkvQCEQvF2= NVz2Sok1OjV|MkK0OVU>
human A431 cells NFjkW4ZRem:uaX\ldoF1cW:wIHHzd4F6 NX3GbYVVPDhiaB?= Ml\IRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEOxJINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEW{YlKgbY4he2W{dX2t[pJm\SCvZXTpeY0h[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHdUXC1zIHHzd4F6NCCHQ{WwQVM5KM7:TR?= MXeyOFQ2PjByNB?=
human MDA-MB-231 cells MnTsVJJwdGmoZYLheIlwdiCjc4PhfS=> M1HVdlI1KGh? NXXiRmF5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? NUTsPWtEOjJ2NUmyNFg>
human HepG2 cells NHT1eHJHfW6ldHnvckBie3OjeR?= Ml3NNlQhcA>? NFzwUWlKdmirYnn0bY9vKG:oIH;s[YlkKGGlaXStbY5lfWOnZDD0dolodHmlZYLp[IUhd3[ncj3hZ4N2dXWuYYTpc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4w> NUfOTVhnOjF6MkS2PVA>
human HepG2 cells MV\GeY5kfGmxbjDhd5NigQ>? M3W3dVI1KGh? MVHBcpRqd3irZHHueEBi[3Srdnn0fUBqdiCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhd2ynaXOgZYNq\C2rbnT1Z4VlKFKRUzDn[Y5memG2aX;uJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IFTIR2YuTEFiYnHz[YQh\my3b4LpcYV1emmlIHHzd4F6KHKnbHH0bZZmKHSxIIXueJJm[XSnZDDjc451em:u M2O5eVIyQDJ2Nkmw
human Caco-2 cells M1SwUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUiyOUDPxE1? NWTlcWdVPiCmYYnz MVzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDDZYNwNTJiY3XscJMh[XRiMkWgeW0h[W[2ZYKgOkBl[Xm| MoPaNVg{OjR5NkO=
mouse 3T3 cells NIDQRldHfW6ldHnvckBie3OjeR?= NYm2THE4OS1{MDFOwG0> NE\ZfXkyOiCq MYfBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGGpYXnud5QhW3erc4OgZYxjcW6xIH3veZNmKDOWMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBk\WyuIH71cYJmenNiYYSgNUB1dyB{MDD1UUBi\nSncjCxNkBpenNiYomgZpkhe2O{YYTjbE14d3WwZDDhd5NigQ>? NHXGeZEzOTB6ME[0Ni=>
human MDA-MB-231 cells NGq5fYFRem:uaX\ldoF1cW:wIHHzd4F6 NHT4RngzPCCq MkPpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> MWOyNlQ2QTJyOB?=
human Jurkat cells NHjtWFdHfW6ldHnvckBie3OjeR?= MlrxNVAuPTVizszN NHLsSGozPCCq Ml\mTY5pcWKrdHnvckBw\iCWTl\hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4TpeoF1cW:wIHnuJIh2dWGwIFr1dotifCClZXzsd{BifCBzMDD0c{A2PSC3TTDh[pRmeiB{NDDodpMh[nliZXzlZ5Rzd3Cqb4LleIlkKG2xYnnsbZR6KHOqaX\0JIF{e2G7 Ml7KNlExQDB4NEK=
human K562 cells NELhc3lHfW6ldHnvckBie3OjeR?= NFn5S3ozPCCq NGjYN|lKdmS3Y4Tpc44hd2ZiNkegb2RiKGyjbXnubY4hemWlZYD0c5Ih\XiycnXzd4lwdiCrbjDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCobH;3JIN6fG:vZYTyfUBidmGueYPpdy=> Mlq3NlE1OzR4MEO=
human HL60 cells NGnnN4NHfW6ldHnvckBie3OjeR?= MlG2NlQhcA>? NIHlbVVKdmS3Y4Tpc44hd2ZiNkegb2RiKGyjbXnubY4hemWlZYD0c5Ih\XiycnXzd4lwdiCrbjDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCobH;3JIN6fG:vZYTyfUBidmGueYPpdy=> MWeyNVQ{PDZyMx?=
human Raji cells NUPLNGtFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfOSVUyOCEQvF2= NGfNXFc1QCCq NGixXIJIem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIGLhbokh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZZQhOTBidV2gZYZ1\XJiNEigbJJ{KGK7IITyfZBidiCkbIXlJIJie2WmIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJIlvKHC{ZYPlcoNmKG:oIIP1dIVzd3irZHWg[Il{dXW2YYPl MWSyNVQ{PDZyMx?=
human PC3 cells NUjPR|YxWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1vPelExNTFyMDFOwG0> NET5T2w1QCCq NIfu[VJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDheEAyOCC2bzCxNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGinbX;jfZRwdWW2cnnjJINmdGxiY3;1cpRqdmdibXX0bI9l MofTNlM5PjdzNke=
human A431 cells MoS0SpVv[3Srb36gZZN{[Xl? NVLrS2NkOTByIN88US=> M33VWFEzKGh? M3vZcnJm\HWldHnvckBw\iClbIXzeIVzcW6pIH;mJGdHWC2JUFmgbY4hdGmyaXSgdoFnfHNib3[gbJVu[W5iQUSzNUBk\WyuczDheEAyODBidV2gZYZ1\XJiMUKgbJJ{KGK7IHPvcoZw[2GuIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nz NULI[3pTOjR2NU[wNFQ>
human SKBR3 cells NVH4UFJ3TnWwY4Tpc44h[XO|YYm= MXGyNFDPxE1? NYnFfY9QOzBibXnudy=> M3\jb2Rwf26{ZXf1cIF1cW:wIH;mJGVz[kJ{IIDyc5RmcW5iZYjwdoV{e2mxbjDpckBpfW2jbjDTT2JTOyClZXzsd{BqdiC|ZYL1cUBnemWnIH3l[Il2dSCjdDCyNFAhfU1iYX\0[ZIhOzBibXnud{BjgSCrbX31co9ndHWxcnXzZ4Vv[2Vic4ThbY5qdmdvYnHz[YQh[2:wZn;jZYwhdWmlcn;zZ49xcWNiYX7hcJl{cXN? MV2yOFQ2PjByNB?=
human 293T cells NV3rT4N4TnWwY4Tpc44h[XO|YYm= M3S0[lUxKM7:TR?= MVyxNkBp MX\Jcohq[mm2aX;uJI9nKES\UluxRUBqdiCqdX3hckAzQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBIVElzIITyZY5{[3KrcITpc44h[WO2aY\peJkh[XRiNUCgeW0h[W[2ZYKgNVIhcHK|IHL5JIR2[WxvbIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NGjEVmUzOjF3NE[2OC=>

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Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
in solvent
Synonyms EGCG

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03624556 Recruiting Down Syndrome|Fragile X Syndrome Parc de Salut Mar|Hospital Infantil Universitario Niño Jesús Madrid Spain|Instituto Hispalense de Pediatría Sevilla Spain|Hospital Universitario Marqués de Valdecilla|Institut Jerome Lejeune January 29 2018 Not Applicable
NCT02891538 Recruiting Colon Cancer The University of Texas Health Science Center at San Antonio January 31 2017 Early Phase 1
NCT02832271 Recruiting Endometriosis Chinese University of Hong Kong December 8 2016 Phase 2
NCT03194620 Completed Healthy University of California Davis|Mars Inc. August 2016 Not Applicable
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02731495 Completed Traumatic Brain Injury National Nutrition and Food Technology Institute|Tehran University of Medical Sciences March 2015 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Telomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID