(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

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In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017, 21(10):2481-2490. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells M2TrT2Z2dmO2aX;uJIF{e2G7 NFXDNpZP\XW{b4Dyc5Rm[3Srb36gZYdicW6|dDDi[ZRiNWGveXzvbYQheGWydHnk[UAyNTR{LXnu[JVk\WRidH;4bYNqfHliaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCuYXP0ZZRmKGSnaInkdo9o\W6jc3WgdoVt\WG|ZTygSWM2OD1yLkCzPVg4KM7:TR?= MXqxPVE{QDh3OR?=
human MDA435/LCC6MDR cells MmLrSpVv[3Srb36gZZN{[Xl? MXyxNEDPxE1? NHG2WFI2KGSjeYO= MX;Nc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrYnzlJI9nKHCjY3zpeIF5\WxicnXzbZN1[W6lZTDt[YF{fXKnZDDhd{BKSzVyIH\vdkBx[WOuaYThfIVtKGG2IEGwJJVOKGGodHXyJFUh\GG7czDifUBE\WyuVHn0[ZIhQTZiQYH1[Y92eyCjc4PhfUwhUUN3ME2wMlEzOjZizszN NV3FW|V5OjV7OEWxPVU>
Sf9 cells MnrtSpVv[3Srb36gZZN{[Xl? MknkTY5pcWKrdHnvckBw\iCKaYO2MZRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDEUm1VOSCneIDy[ZN{\WRiaX6gbY5{\WO2IGPmPUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iRF7BJI1mfGi7bITyZY5{\mW{YYPlJIFkfGm4aYT5JJV{cW6pIEWnMYJqd3SrbonsZZRm\CB2NT3idEB2dm2ndHj5cIF1\WRib4KgbIVucW2ndHj5cIF1\WRib3zp[49vfWOuZX;0bYRmKHO3YoP0doF1\XNiYX7kJHs{UF1vQXTvUYV1KGK7IHzpdZVq\CC|Y3nueIltdGG2aX;uJINwfW62aX7nJI1mfGixZDygTWM2OD1yLkWg{txO M4O1fVI2PDB4OUS0
human U937 cells NUn0SndwTnWwY4Tpc44h[XO|YYm= MorPTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIGW5N|ch[2WubIOsJGlEPTB;MTFOwG0> MXKyNlQyOzh2NR?=
human HeLa cells NEK2U2VHfW6ldHnvckBie3OjeR?= MYXJcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iSHXMZUBk\WyuczD1d4lv\yB3Jz3BRXQhS0OJIGTDS{BCT0NiQVfBJGdVXC1|JzDhd{B{fWK|dILheIUhcW6ldXLheIVlKG[xcjCxOUBucW6|IIDybY9zKHSxIHX4eIVve2mxbjDy[YFkfGmxbjDmc4xtd3enZDDifUBkd22yb4Xu[EB4[XOqb4X0JIJ6KHOyaX6teIVtd22ncnnjJJJmeGWjdDDhcZBtcW[rY3H0bY9vKHC{b4TvZ49tNCCLQ{WwQVEvODhizszN NWnMb5p[OjJ2MUO4OFU>
CHO cells MV;DfZRwfG:6aXRCpIF{e2G7 MnfjOFghcA>? NH30Zm9EgXSxdH;4bYNqfHliYXfhbY5{fCCFSF:gZ4VtdHNiZYjwdoV{e2mwZzDPRXRROUJ|IHjhdIxwfHmyZTCxJIFnfGW{IES4JIhzeyCkeTDmcJVwemW|Y3XuZ4Uh[mG|ZXSgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3ME2zMlIh|ryP NEL5[lkzOzN{N{i3Oy=>
MDCK cells M1T5OWZ2dmO2aX;uJIF{e2G7 NVTnTXljPCCmYYnz NUnLWmt6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhMEFxc4fpcoUwV0hxNUGxOFQ2NzJyMEeoTFFPOSlrIF;oO{Bqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPCCmYYnzJIJ6KHG3YX70bZRifGm4ZTDSWE1RS1JuIFXEOVA:QC5|IN88US=> NUHJSlZmOjJzMUW1PVE>
human HL60 cells NIP1VnRRem:uaX\ldoF1cW:wIHHzd4F6 M2HFXVMh\GG7cx?= Mn\FRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDNiZHH5d{whUUN3ME25MlQh|ryP MXOxPFY6OzB{MB?=
HSC-T6 cells  NF:0Z21HfW6ldHnvckBie3OjeR?= MlTyOFghcA>? NF\ueVZCdnSrZnnido91cWNiYXP0bZZqfHliYXfhbY5{fCC{YYSgTHNENVR4IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliQoLkWUBqdmOxcoDvdoF1cW:wIHHzd4F6NCCLQ{WwQVkvQSEQvF2= M2HsUFIyPTB2OES4
mouse 3T3-L1 cells NXG0UGhvTnWwY4Tpc44h[XO|YYm= M4fEZ2lvcGmkaYTpc44hd2ZiR{\QSE1u\WSrYYTl[EBPSUSSSDDwdo9lfWO2aX;uJIlvKG2xdYPlJFNVOy2OMTDj[YxteyxiSVO1NF0zPSEQvF2= NVizcIlVOTh|MUOzNFg>
mouse RAW264.7 cells NVHFZphETnWwY4Tpc44h[XO|YYm= MWK1JIRigXN? NGfrUWhKdmirYnn0bY9vKG:oIGLBUmtNNWmwZIXj[YQhd3O2ZX;jcIF{fG:pZX7ld4l{KGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIGTSRXAueG:|aYTpeoUhdXWudHmtcpVkdGWjdHXkJINmdGy|IHHmeIVzKDViZHH5d{whUUN3ME2yPU45KM7:TR?= NVrmXHE4OjF2NU[1NlE>
HSC-T6 cells NH3HTldRem:uaX\ldoF1cW:wIHHzd4F6 MkHlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDyZZQhUFOFLWS2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUwhUUN3ME2yPU45KM7:TR?= MknENlU{OjJ2NUW=
human A431 cells MYLQdo9tcW[ncnH0bY9vKGG|c3H5 NW\iVVZ6PDhiaB?= Mon2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEOxJINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEW{YlKgbY4he2W{dX2t[pJm\SCvZXTpeY0h[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JHdUXC1zIHHzd4F6NCCHQ{WwQVM5KM7:TR?= MVOyOFQ2PjByNB?=
human MDA-MB-231 cells MnS4VJJwdGmoZYLheIlwdiCjc4PhfS=> M2TrU|I1KGh? M{ezPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6 MYqyNlQ2QTJyOB?=
human HepG2 cells M{nxdGZ2dmO2aX;uJIF{e2G7 NFvjelczPCCq NFLVdIVKdmirYnn0bY9vKG:oIH;s[YlkKGGlaXStbY5lfWOnZDD0dolodHmlZYLp[IUhd3[ncj3hZ4N2dXWuYYTpc44hcW5iaIXtZY4hUGWyR{KgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4w> MnTrNlE5OjR4OUC=
human HepG2 cells MXTGeY5kfGmxbjDhd5NigQ>? M{jre|I1KGh? NXT3fnNYSW62aX;4bYRidnRiYXP0bZZqfHliaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIH;s[YlkKGGlaXStbY5lfWOnZDDSU3Mh\2WwZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBFUEOILVTBJIJie2WmIH\seY9zcW2ndILpZ{Bie3OjeTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcC=> NF73Rm4zOTh{NE[5NC=>
human Caco-2 cells NH7vR4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYSwZ|c5OjVizszN MUW2JIRigXN? NWj2S2xrT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS2Glbz2yJINmdGy|IHH0JFI2KHWPIHHmeIVzKDZiZHH5dy=> NHXObYYyQDN{NEe2Ny=>
mouse 3T3 cells NEn2XYtHfW6ldHnvckBie3OjeR?= Mn3YNU0zOCEQvF2= NIHoU|UyOiCq MU\BcpRqdWmpcnH0c5J6KGGldHn2bZR6KGGpYXnud5QhW3erc4OgZYxjcW6xIH3veZNmKDOWMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBk\WyuIH71cYJmenNiYYSgNUB1dyB{MDD1UUBi\nSncjCxNkBpenNiYomgZpkhe2O{YYTjbE14d3WwZDDhd5NigQ>? MljpNlExQDB4NEK=
human MDA-MB-231 cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 MVWyOEBp M3q4RWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6 MVuyNlQ2QTJyOB?=
human Jurkat cells NIe5VppHfW6ldHnvckBie3OjeR?= MV[xNE02PSEQvF2= NH\sc4UzPCCq M2H0S2lvcGmkaYTpc44hd2ZiVF7GZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjDKeZJs[XRiY3XscJMh[XRiMUCgeI8hPTVidV2gZYZ1\XJiMkSgbJJ{KGK7IHXs[YN1em:yaH;y[ZRq[yCvb3LpcIl1gSC|aHnmeEBie3OjeR?= NGfUdYczOTB6ME[0Ni=>
human K562 cells MkjuSpVv[3Srb36gZZN{[Xl? MUWyOEBp MXzJcoR2[3Srb36gc4YhPjdia1ThJIxidWmwaX6gdoVk\XC2b4Kg[ZhxemW|c3nvckBqdiCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFI1KGi{czDifUBndG:5IHP5eI9u\XS{eTDhcoFtgXOrcx?= NXnUPIx7OjF2M{S2NFM>
human HL60 cells MnHRSpVv[3Srb36gZZN{[Xl? NVH3UGFkOjRiaB?= MojKTY5lfWO2aX;uJI9nKDZ5IHvEZUBt[W2rbnnuJJJm[2WydH;yJIV5eHKnc4Ppc44hcW5iaIXtZY4hUEx4MDDj[YxteyCjZoTldkAzPCCqcoOgZpkh\myxdzDjfZRwdWW2comgZY5idHm|aYO= Mn3MNlE1OzR4MEO=
human Raji cells NEP4c45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHubplHOTBizszN NV;MfGxGPDhiaB?= MV7Hdo94fGhiaX7obYJqfGmxbjDh[4FqdnO2IHj1cYFvKFKjanmgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYYSgNVAhfU1iYX\0[ZIhPDhiaILzJIJ6KHS{eYDhckBjdHWnIHLhd4VlKG2rY4Lvd4NweGmlIHHuZYx6e2m|IHnuJJBz\XOnbnPlJI9nKHO3cHXyc5hq\GViZHnzcZV1[XOn Ml\vNlE1OzR4MEO=
human PC3 cells MX3Qdo9tcW[ncnH0bY9vKGG|c3H5 MlK3NVAuOTByIN88US=> NYSxPHN4PDhiaB?= NFnEfmdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDheEAyOCC2bzCxNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGinbX;jfZRwdWW2cnnjJINmdGxiY3;1cpRqdmdibXX0bI9l NFHPfJEzOzh4N{G2Oy=>
human A431 cells M1zBSmZ2dmO2aX;uJIF{e2G7 MY[xNFAh|ryP MYGxNkBp Mn\VVoVlfWO2aX;uJI9nKGOudYP0[ZJqdmdib3[gS2ZRNUeSSTDpckBtcXCrZDDyZYZ1eyCxZjDoeY1idiCDNEOxJINmdGy|IHH0JFExOCC3TTDh[pRmeiBzMjDodpMh[nliY3;u[o9k[WxibXnjdo9{[2:yaXOgZY5idHm|aYO= MkXSNlQ1PTZyMES=
human SKBR3 cells NYToN3dHTnWwY4Tpc44h[XO|YYm= NUjLWHhJOjByzszN NIDHUm8{OCCvaX7z M2XEUGRwf26{ZXf1cIF1cW:wIH;mJGVz[kJ{IIDyc5RmcW5iZYjwdoV{e2mxbjDpckBpfW2jbjDTT2JTOyClZXzsd{BqdiC|ZYL1cUBnemWnIH3l[Il2dSCjdDCyNFAhfU1iYX\0[ZIhOzBibXnud{BjgSCrbX31co9ndHWxcnXzZ4Vv[2Vic4ThbY5qdmdvYnHz[YQh[2:wZn;jZYwhdWmlcn;zZ49xcWNiYX7hcJl{cXN? Mom2NlQ1PTZyMES=
human 293T cells MUfGeY5kfGmxbjDhd5NigQ>? NYLpSYh{PTBizszN M4fPT|EzKGh? MYrJcohq[mm2aX;uJI9nKES\UluxRUBqdiCqdX3hckAzQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBIVElzIITyZY5{[3KrcITpc44h[WO2aY\peJkh[XRiNUCgeW0h[W[2ZYKgNVIhcHK|IHL5JIR2[WxvbIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NUX3e|h4OjJzNUS2OlQ>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
in solvent
Synonyms EGCG

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02891538 Recruiting Colon Cancer The University of Texas Health Science Center at San Antonio January 31 2017 Early Phase 1
NCT03624556 Recruiting Down Syndrome|Fragile X Syndrome Parc de Salut Mar|Hospital Infantil Universitario Niño Jesús Madrid Spain|Instituto Hispalense de Pediatría Sevilla Spain|Hospital Universitario Marqués de Valdecilla|Institut Jerome Lejeune January 29 2018 Not Applicable
NCT02011451 Withdrawn Multiple Sclerosis Louisiana State University Health Sciences Center in New Orleans|National Multiple Sclerosis Society December 2015 Phase 2
NCT02558933 Unknown status Fetal Alcohol Syndrome (FAS) Parc de Salut Mar|Fundación Mutua Madrileña June 2015 Phase 2|Phase 3
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02580279 Enrolling by invitation Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute February 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Telomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID