(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

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In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017, 21(10):2481-2490. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells NWrGcJRUTnWwY4Tpc44h[XO|YYm= MVfO[ZVzd3C{b4TlZ5Rqd25iYXfhbY5{fCCkZYThMYFugWyxaXSgdIVxfGmmZTCxMVQzNWmwZIXj[YQhfG:6aXPpeJkhcW5iaIXtZY4hW0hvU2m1XUBk\WyuczDhd5Nme3OnZDDhd{Bt[WO2YYTlJIRmcHmmcn;n[Y5ie2VicnXs[YF{\SxiRVO1NF0xNjB|OUi3JO69VQ>? M{\Xd|E6OTN6OEW5
human MDA435/LCC6MDR cells NIjvSGNHfW6ldHnvckBie3OjeR?= NYTIXZA5OTBizszN NG[x[G02KGSjeYO= M{T6UG1w\HWuYYTpc44hd2ZiUD3ndEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKE2GQUSzOU9NS0N4TVTSJINmdGy|IHHzd4V{e2WmIHHzJJJmfmW{c3nicIUhd2ZicHHjcIl1[XinbDDy[ZNqe3SjbnPlJI1m[XO3cnXkJIF{KEmFNUCg[o9zKHCjY3zpeIF5\WxiYYSgNVAhfU1iYX\0[ZIhPSCmYYnzJIJ6KEOnbHzUbZRmeiB7NjDBdZVmd3W|IHHzd4F6NCCLQ{WwQVAvOTJ{NjFOwG0> NYTkTZk1OjV7OEWxPVU>
Sf9 cells MmrnSpVv[3Srb36gZZN{[Xl? M1nR[WlvcGmkaYTpc44hd2ZiSHnzOk11[WepZXSgbJVu[W5icnXjc41jcW6jboSgSG5OXDFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFTORUBu\XSqeXz0doFve2[ncnHz[UBi[3Srdnn0fUB2e2mwZzC1K{1jcW:2aX75cIF1\WRiNEWtZpAhfW6vZYTofYxifGWmIH;yJIhmdWmvZYTofYxifGWmIH;sbYdwdnWlbHXveIll\SC|dXLzeJJifGW|IHHu[EBcO0ifLVHkc21mfCCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{Bu\XSqb3SsJGlEPTB;MD61JO69VQ>? NHj3ZnczPTRyNkm0OC=>
human U937 cells MXfGeY5kfGmxbjDhd5NigQ>? NV;EdJlWUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHU6OzdiY3XscJMtKEmFNUC9NUDPxE1? NVrqWIJHOjJ2MUO4OFU>
human HeLa cells MXHGeY5kfGmxbjDhd5NigQ>? M4S1WmlvcGmkaYTpc44hd2ZidHXsc41memG|ZTDpckBpfW2jbjDI[WxiKGOnbHzzJJV{cW6pIEWnMWFCXCCFQ1egWGNIKEGJQzDBS2EhT1SWLUOnJIF{KHO3YoP0doF1\SCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:g[Zh1\W6|aX;uJJJm[WO2aX;uJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHejc3jveZQh[nlic4Dpck11\WyxbXXybYMhemWyZXH0JIFueGyrZnnjZZRqd25icILveI9kd2xuIFnDOVA:OS5yODFOwG0> MYCyNlQyOzh2NR?=
CHO cells MUHDfZRwfG:6aXRCpIF{e2G7 NWm4VnFnPDhiaB?= NGrFUnpEgXSxdH;4bYNqfHliYXfhbY5{fCCFSF:gZ4VtdHNiZYjwdoV{e2mwZzDPRXRROUJ|IHjhdIxwfHmyZTCxJIFnfGW{IES4JIhzeyCkeTDmcJVwemW|Y3XuZ4Uh[mG|ZXSgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3ME2zMlIh|ryP NX:ycmVqOjN|Mke4O|c>
MDCK cells M4q5VmZ2dmO2aX;uJIF{e2G7 M1jFbFQh\GG7cx?= NF;vUItCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBqdm[udXXufoEhSSC4aYL1d{ApSS:|d3nu[U9QUC93MUG0OFUwOjByNzjINW4yMSliT3i3JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA1KGSjeYOgZpkheXWjboTpeIF1cX[nIGLUMXBEWixiRVS1NF05NjNizszN NVHjVGNDOjJzMUW1PVE>
human HL60 cells NFrwUFZRem:uaX\ldoF1cW:wIHHzd4F6 MnrTN{Bl[Xm| NXzVfWE5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEOg[IF6eyxiSVO1NF06NjRizszN NGLXXHoyQDZ7M{CyNC=>
HSC-T6 cells  M1Lz[mZ2dmO2aX;uJIF{e2G7 MVu0PEBp MnvuRY51cW[rYoLveIlkKGGldHn2bZR6KGGpYXnud5QhemG2IFjTR{1VPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{ZGWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME25Mlkh|ryP NG\xPJQzOTVyNEi0PC=>
mouse 3T3-L1 cells M375RWZ2dmO2aX;uJIF{e2G7 MXjJcohq[mm2aX;uJI9nKEd4UFStcYVlcWG2ZXSgUmFFWEhicILv[JVkfGmxbjDpckBud3W|ZTCzWFMuVDFiY3XscJMtKEmFNUC9NlUh|ryP NFTSOXQyQDNzM{OwPC=>
mouse RAW264.7 cells MWnGeY5kfGmxbjDhd5NigQ>? M2rjSlUh\GG7cx?= M3jCcGlvcGmkaYTpc44hd2ZiUlHOT2wucW6mdXPl[EBwe3Snb3PsZZN1d2enbnXzbZMhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iVGLBVE1xd3OrdHn2[UBufWy2aT3ueYNt\WG2ZXSgZ4VtdHNiYX\0[ZIhPSCmYYnzMEBKSzVyPUK5Mlgh|ryP NXq0ZlFbOjF2NU[1NlE>
HSC-T6 cells Mn;MVJJwdGmoZYLheIlwdiCjc4PhfS=> MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IILheEBJW0NvVE[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUK5Mlgh|ryP M2PLbVI2OzJ{NEW1
human A431 cells MWHQdo9tcW[ncnH0bY9vKGG|c3H5 M17kSlQ5KGh? M2XOZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDveoVz\XiycnXzd4lv\yCHcnLCJIlvKHOncoXtMYZz\WVibXXkbZVuKGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBYW1RvMTDhd5NigSxiRVO1NF0{QCEQvF2= M2WyRVI1PDV4MEC0
human MDA-MB-231 cells NEmwUHFRem:uaX\ldoF1cW:wIHHzd4F6 NHfnWZUzPCCq MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> MmK3NlI1PTl{MEi=
human HepG2 cells NVW0enVyTnWwY4Tpc44h[XO|YYm= M4ToU|I1KGh? M2W0[mlvcGmkaYTpc44hd2Zib3zlbYMh[WOrZD3pcoR2[2WmIITybYdtgWOncnnk[UBwfmW{LXHjZ5VufWyjdHnvckBqdiCqdX3hckBJ\XCJMjDj[YxteyCrbnP1ZoF1\WRiZn;yJFI1KGi{czDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcC=> MV:yNVgzPDZ7MB?=
human HepG2 cells MX7GeY5kfGmxbjDhd5NigQ>? NGO2fHEzPCCq NXrpNmM4SW62aX;4bYRidnRiYXP0bZZqfHliaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIH;s[YlkKGGlaXStbY5lfWOnZDDSU3Mh\2WwZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBFUEOILVTBJIJie2WmIH\seY9zcW2ndILpZ{Bie3OjeTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcC=> NEXHc48zOTh{NE[5NC=>
human Caco-2 cells NHPW[5lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfyNIIzPSEQvF2= MUC2JIRigXN? NHnFfplIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBE[WOxLUKgZ4VtdHNiYYSgNlUhfU1iYX\0[ZIhPiCmYYnz M{fWRVE5OzJ2N{[z
mouse 3T3 cells Mo\WSpVv[3Srb36gZZN{[Xl? M4rW[lEuOjBizszN NEX1TXUyOiCq MULBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGGpYXnud5QhW3erc4OgZYxjcW6xIH3veZNmKDOWMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBk\WyuIH71cYJmenNiYYSgNUB1dyB{MDD1UUBi\nSncjCxNkBpenNiYomgZpkhe2O{YYTjbE14d3WwZDDhd5NigQ>? MUSyNVA5ODZ2Mh?=
human MDA-MB-231 cells MWrQdo9tcW[ncnH0bY9vKGG|c3H5 NYrPNJoyOjRiaB?= NF\jSZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigQ>? M{DjNVIzPDV7MkC4
human Jurkat cells MX3GeY5kfGmxbjDhd5NigQ>? NFPDcoEyOC13NTFOwG0> NHyxXmUzPCCq MV;Jcohq[mm2aX;uJI9nKFSQRnHsdIhiNWmwZIXj[YQhVkZva3HwdIFDKGGldHn2ZZRqd25iaX6gbJVu[W5iSoXyb4F1KGOnbHzzJIF1KDFyIITvJFU2KHWPIHHmeIVzKDJ2IHjyd{BjgSCnbHXjeJJweGixcnX0bYMhdW:kaXzpeJkhe2irZoSgZZN{[Xl? M2PLcFIyODhyNkSy
human K562 cells MV;GeY5kfGmxbjDhd5NigQ>? MoTqNlQhcA>? NVHUZ2lEUW6mdXP0bY9vKG:oIE[3JItF[SCuYX3pcolvKHKnY3XweI9zKGW6cILld5Nqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB{NDDodpMh[nliZnzve{BkgXSxbXX0dpkh[W6jbInzbZM> NIfKe|czOTR|NE[wNy=>
human HL60 cells NUKyWpYxTnWwY4Tpc44h[XO|YYm= MX:yOEBp M3j6ZWlv\HWldHnvckBw\iB4NzDrSIEhdGGvaX7pckBz\WOncITvdkBmgHC{ZYPzbY9vKGmwIHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KG[ub4egZ5l1d22ndIL5JIFv[Wy7c3nz NEDEc3ozOTR|NE[wNy=>
human Raji cells NFfZZWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVmxNEDPxE1? NEfLbYU1QCCq M2SyRWdzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iUnHqbUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDh[pRmeiB2ODDodpMh[nlidIL5dIFvKGKudXWgZoF{\WRibXnjdo9{[2:yaXOgZY5idHm|aYOgbY4heHKnc3XuZ4Uhd2Zic4Xw[ZJwgGmmZTDkbZNufXSjc3W= NXvZRYxzOjF2M{S2NFM>
human PC3 cells NHfDcFlRem:uaX\ldoF1cW:wIHHzd4F6 MknpNVAuOTByIN88US=> NIfTUJM1QCCq MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjdDCxNEB1dyBzMECgeW0h[W[2ZYKgOFghcHK|IHL5JIhmdW:leYTvcYV1emmlIHPlcIwh[2:3boTpcochdWW2aH;k M2W0TlI{QDZ5MU[3
human A431 cells M3fzPGZ2dmO2aX;uJIF{e2G7 MXKxNFAh|ryP NVf0e4hqOTJiaB?= MmG5VoVlfWO2aX;uJI9nKGOudYP0[ZJqdmdib3[gS2ZRNUeSSTDpckBtcXCrZDDyZYZ1eyCxZjDoeY1idiCDNEOxJINmdGy|IHH0JFExOCC3TTDh[pRmeiBzMjDodpMh[nliY3;u[o9k[WxibXnjdo9{[2:yaXOgZY5idHm|aYO= M1;pNlI1PDV4MEC0
human SKBR3 cells NWXZNJV2TnWwY4Tpc44h[XO|YYm= MmHoNlAx|ryP NV3IW3ZtOzBibXnudy=> MWHEc5dvemWpdXzheIlwdiCxZjDFdoJDOiCycn;0[YlvKGW6cILld5Nqd25iaX6gbJVu[W5iU1vCVlMh[2WubIOgbY4he2W{dX2g[pJm\SCvZXTpeY0h[XRiMkCwJJVOKGGodHXyJFMxKG2rboOgZpkhcW2vdX7v[ox2d3Knc3PlcoNmKHO2YXnubY5oNWKjc3XkJINwdm[xY3HsJI1q[3Kxc3PvdIlkKGGwYXz5d4l{ NXrCSFhuOjR2NU[wNFQ>
human 293T cells MYLGeY5kfGmxbjDhd5NigQ>? M1L2[VUxKM7:TR?= M{LmUVEzKGh? NE\yOplKdmirYnn0bY9vKG:oIFTZVmsySSCrbjDoeY1idiB{OUPUJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCJTFmxJJRz[W6|Y4LpdJRqd25iYXP0bZZqfHliYYSgOVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGS3YXytcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 M1XHc|IzOTV2Nk[0

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
in solvent
Synonyms EGCG

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03624556 Recruiting Down Syndrome|Fragile X Syndrome Parc de Salut Mar|Hospital Infantil Universitario Niño Jesús Madrid Spain|Instituto Hispalense de Pediatría Sevilla Spain|Hospital Universitario Marqués de Valdecilla|Institut Jerome Lejeune January 29 2018 Not Applicable
NCT02891538 Recruiting Colon Cancer The University of Texas Health Science Center at San Antonio January 31 2017 Early Phase 1
NCT02832271 Recruiting Endometriosis Chinese University of Hong Kong December 8 2016 Phase 2
NCT03194620 Completed Healthy University of California Davis|Mars Inc. August 2016 Not Applicable
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02731495 Completed Traumatic Brain Injury National Nutrition and Food Technology Institute|Tehran University of Medical Sciences March 2015 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Telomerase Signaling Pathway Map

Related Telomerase Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID