Oxyresveratrol

For research use only.

Catalog No.S4739 Synonyms: Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene

Oxyresveratrol Chemical Structure

CAS No. 29700-22-9

Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.

Purity & Quality Control

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Biological Activity

Description Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
Targets
tyrosinase [1] DPPH [2]
28.9 μM
In vitro

Oxyresveratrol has been reported to inhibit β-amyloid-induced neurotoxicity in cultured cortical neurons and in vitro activity of β-secretase, an enzyme vital for the production of the Aβ protein. And it can also prevent neurotoxicity and DNA damage through its antioxidant properties in cultured neuronal cells. It shows modest inhibitory activity against H5N1 neuraminidase (an enzyme found in avian influenza virus), but strong inhibition against α-glucosidase, an enzyme responsible for the breaking down of starch and polysaccharides into glucose in the intestine[1]. Oxyresveratrol is an effective radical scavenger[2]. Oxyresveratrol protects hepatocytes against oxidative stress, mitochondrial damage, and resultant cell death. It induces activation of an antioxidant transcription factor, Nrf2, mediated through ERK phosphorylation[3].

In vivo Oxyresveratrol has been reported to undergo extensive hepatic metabolism and rapid urinary elimination, resulting in a short half-life time, and thereby restricting its clinical use. Moreover, its postulated function as a preventive agent for neurodegenerative disorders, such as AD or PD, appears to be hindered by its low ability to cross the blood-brain barrier (BBB). Despite its moderate in vitro inhibitory activity against herpes simplex virus type I (HSV-1), oxyresveratrol, in the form of topical cream, exhibits high therapeutic efficacy in mice cutaneously infected with HSV-1, with a potency comparable to that of the antiviral drug acyclovir[1]. Oxyresveratrol ameliorates acute liver injury caused by CCl4 in mice[3].

Protocol

Cell Research:[2]
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  • Cell lines: N9 microglial cells
  • Concentrations: 25, 50, and 100 μM
  • Incubation Time: 18 h
  • Method: Cytotoxicity assays are performed by the trypan blue method. The cell cultures (N9 or C6 cell line, 2 mL medium each) are treated with 100 μL trypsin-EDTA, incubated for 5 min at 37℃, and then suspended with a pipette. The cell suspension is treated with 20 μL of 0.4% (wt/vol) trypan blue solution and the ratio of living/dead cells is determined immediately by counting the cells in a 20 μL aliquot in a Neubauer chamber under a microscope.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: C57BL/6 male mice
  • Dosages: 10 or 30 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 48 mg/mL (196.52 mM)
Ethanol 48 mg/mL (196.52 mM)
Water 1 mg/mL (4.09 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.24
Formula

C14H12O4

CAS No. 29700-22-9
Storage powder
in solvent
Synonyms Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene
Smiles C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID