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Oxyresveratrol Tyrosinase inhibitor

Name: Oxyresveratrol
Brand: Selleck Chemicals
SKU: S4739
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4739

Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.

Chemical Structure

Molecular Weight: 244.24

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.68%

99.68

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Chemical Information, Storage & Stability

Molecular Weight	244.24	Formula	C₁₄H₁₂O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	29700-22-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene			Smiles	C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (200.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 49 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.000mg/ml (12.28mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.250mg/ml (1.02mM)	Taking the 1 mL working solution as an example, add 50 μL of 5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	tyrosinase ^[1] DPPH ^[2] 28.9 μM
In vitro	Oxyresveratrol has been reported to inhibit β-amyloid-induced neurotoxicity in cultured cortical neurons and in vitro activity of β-secretase, an enzyme vital for the production of the Aβ protein. And it can also prevent neurotoxicity and DNA damage through its antioxidant properties in cultured neuronal cells. This compound shows modest inhibitory activity against H5N1 neuraminidase (an enzyme found in avian influenza virus), but strong inhibition against α-glucosidase, an enzyme responsible for the breaking down of starch and polysaccharides into glucose in the intestine^[1]. It is an effective radical scavenger^[2]. This chemical protects hepatocytes against oxidative stress, mitochondrial damage, and resultant cell death. It induces activation of an antioxidant transcription factor, Nrf2, mediated through ERK phosphorylation^[3].
In vivo	Oxyresveratrol has been reported to undergo extensive hepatic metabolism and rapid urinary elimination, resulting in a short half-life time, and thereby restricting its clinical use. Moreover, its postulated function as a preventive agent for neurodegenerative disorders, such as AD or PD, appears to be hindered by its low ability to cross the blood-brain barrier (BBB). Despite its moderate in vitro inhibitory activity against herpes simplex virus type I (HSV-1), this compound, in the form of topical cream, exhibits high therapeutic efficacy in mice cutaneously infected with HSV-1, with a potency comparable to that of the antiviral drug acyclovir^[1]. It ameliorates acute liver injury caused by CCl4 in mice^[3].
References	[1] https://pubmed.ncbi.nlm.nih.gov/27104505/ [2] https://pubmed.ncbi.nlm.nih.gov/14623172/ [3] https://pubmed.ncbi.nlm.nih.gov/26102008/

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