Home DNA Damage/DNA Repair Sirtuin activator Nicotinamide Riboside Chloride For research use only.

Nicotinamide Riboside Chloride

Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

Nicotinamide Riboside Chloride Chemical Structure

Nicotinamide Riboside Chloride Chemical Structure

CAS: 23111-00-4

Selleck's Nicotinamide Riboside Chloride has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.98%
99.98

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Signaling Pathway

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Biological Activity

Description Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
In vitro
In vitro

Nicotinamide Riboside supplementation increases NAD+ content and sirtuin activity in cultured mammalian cells.[1]
Cell Research Cell lines C2C12 myotubes, Hepa1.6 and HEK293T cells
Concentrations 0-1000 μM
Incubation Time 24 h
Method

--
In Vivo
In vivo

Nicotinamide Riboside, a precursor to nicotinamide adenine dinucleotide(NAD), restores tissue NAD+ depletion induced by acute kidney injury (AKI) to that of the sham group, increases autophagy and sirtuin1 (Sirt1).[2]
Animal Research Animal Models Two-month-old male Wistar rats
Dosages 500 g/kg/day
Administration o.g.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04614714 Not yet recruiting
Preterm Birth|Inadequate Milk Production
University of California Davis
 December 2024 Phase 2|Phase 3
NCT06145659 Not yet recruiting
Developmental Delay
University of Illinois at Chicago|National Institutes of Health (NIH)|National Institute of Nursing Research (NINR)
 February 2024 Not Applicable
NCT06032923 Not yet recruiting
Systemic Lupus Erythematosus (Sle)
National Heart Lung and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC)
 January 12 2024 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 290.7 Formula

C11H15ClN2O5
CAS No. 23111-00-4 SDF --
Smiles C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 58 mg/mL ( (199.51 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 58 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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