Nicotinamide Riboside Chloride

Catalog No.S2935

For research use only.

Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

Nicotinamide Riboside Chloride Chemical Structure

CAS No. 23111-00-4

Selleck's Nicotinamide Riboside Chloride has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 58 mg/mL
(199.51 mM)
Water 58 mg/mL
(199.51 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 290.7
Formula

C11H15ClN2O5

CAS No. 23111-00-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04059757 Not yet recruiting Biological: Fecal Microbiota Transplantation (FMT) Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD) Leland Metheny|Case Comprehensive Cancer Center October 2021 Phase 2
NCT04975789 Not yet recruiting Other: InfoViz Communication|Pain University of Wisconsin Madison|National Institute of Nursing Research (NINR) October 2021 Not Applicable
NCT04368130 Not yet recruiting Behavioral: SIGNAL Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|Uterine Cancer|Cervical Cancer|Gynecologic Cancer Dana-Farber Cancer Institute|National Institute of Nursing Research (NINR) September 1 2021 Not Applicable
NCT04614714 Not yet recruiting Drug: Nicotinamide riboside chloride|Drug: Placebo Preterm Birth|Inadequate Milk Production University of California Davis August 2021 Phase 2|Phase 3
NCT04809974 Recruiting Drug: Niagen Covid19|Sequelae of; Infection|Cognitive Symptom Massachusetts General Hospital July 22 2021 Phase 4
NCT04910152 Not yet recruiting Drug: BRD4 Inhibitor PLX51107 Acute Graft Versus Host Disease|Steroid Refractory Graft Versus Host Disease Ayman Saad|Ohio State University Comprehensive Cancer Center July 1 2021 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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