Catalog No.S2342 Synonyms: Dihydronaringenin
Molecular Weight(MW): 274.27
Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
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Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)
J Transl Med, 2017, 15:158. Phloretin purchased from Selleck.
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|Description||Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.|
Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin.  Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption.   Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. 
|In vitro||DMSO||54 mg/mL (196.88 mM)|
|Ethanol||54 mg/mL (196.88 mM)|
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