Phloretin (RJC 02792)

Catalog No.S2342 Synonyms: NSC 407292, Dihydronaringenin

For research use only.

Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

Phloretin (RJC 02792) Chemical Structure

CAS No. 60-82-2

Selleck's Phloretin (RJC 02792) has been cited by 5 Publications

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Biological Activity

Description Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
Targets
SGLT1 [1]
()
SGLT2 [1]
()
In vitro

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 cells NEXxTIVHfW6ldHnvckBie3OjeR?= MVyzNEBucW6| MnHtTY5pcWKrdHnvckBw\iCJTGXUNUBqdiCqdX3hckBJOTJ7OTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKDJvZHXvfJkuTC2dM1jdMYdtfWOxc3WgeZB1[WunIHnuZ5Vj[XSnZDDmc5IhOTVibXnud{BxemmxcjD0c{AzNWSnb4j5MWQuYzOKXT3ncJVkd3OnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nlibHnxeYllKHOlaX70bYxt[XSrb36gZ492dnSrbnegZY5idHm|aYOsJGlEPTB;MkGuOEDPpG1? NHKzSYwzPDJyMEiwPC=>
PK15NTD cells NWTEUI5FTnWwY4Tpc44h[XO|YYm= M2CyN2JqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVkd22kaX7hcpQhS06WMzDlfJBz\XO|ZXSgbY4heGmpIGDLNVVPXERiY3XscJMh[XO|ZYPz[YQh[XNiW{PIYZVzcWSrbnWgeZB1[WunIHL5JIJmfGFvc3PpcpRqdGyjdHnvckwhU2l;M{KuNlgh|ryP MkPpNVkxQTd5N{i=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 54 mg/mL
(196.88 mM)
Ethanol 54 mg/mL
(196.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 274.27
Formula

C15H14O5

CAS No. 60-82-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05073523 Recruiting Other: Diet Healthy Chalmers University of Technology September 27 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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