Phloretin

Catalog No.S2342 Synonyms: Dihydronaringenin

Phloretin Chemical Structure

Molecular Weight(MW): 274.27

Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 70 In stock
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Cited by 1 Publication

1 Customer Review

  • Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)

    J Transl Med, 2017, 15:158. Phloretin purchased from Selleck.

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Biological Activity

Description Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
Targets
SGLT1 [1]
()
SGLT2 [1]
()
In vitro

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 cells M2fOW2Z2dmO2aX;uJIF{e2G7 M{PDRVMxKG2rboO= NYSwXGpwUW6qaXLpeIlwdiCxZjDHUHVVOSCrbjDoeY1idiCKMUK5PUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIEKt[IVwgHlvRD3bN2heNWeudXPvd4UhfXC2YXvlJIlv[3WkYYTl[EBnd3JiMUWgcYlveyCycnnvdkB1dyB{LXTlc5h6NURvW{PIYU1odHWlb4PlJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEOwJI1qdnNiYomgcIlyfWmmIIPjbY51cWyuYYTpc44h[2:3boTpcoch[W6jbInzbZMtKEmFNUC9NlEvPCEQnH2= NWiyRXFVOjR{MEC4NFg>
PK15NTD cells MU\GeY5kfGmxbjDhd5NigQ>? MWnCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JGNPXDNiZYjwdoV{e2WmIHnuJJBq\yCSS{G1UnRFKGOnbHzzJIF{e2W|c3XkJIF{KFt|SG31dollcW6nIIXweIFs\SCkeTDi[ZRiNXOlaX70bYxt[XSrb36sJGtqRTN{LkK4JO69VQ>? NHTPZ4YyQTB7N{e3PC=>

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Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (196.88 mM)
Ethanol 54 mg/mL (196.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 274.27
Formula

C15H14O5

CAS No. 60-82-2
Storage powder
in solvent
Synonyms Dihydronaringenin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID