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Thiamine monochloride Vitamin chemical

Name: Thiamine monochloride
Brand: Selleck Chemicals
SKU: S4486
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4486

Thiamine (Vitamin B1) monochloride is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.

Chemical Structure

Molecular Weight: 300.81

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S448601 DMSO]60 mg/mL]false]Water]60 mg/mL]false]Ethanol]Insoluble]false Purity: 99.96%

99.96

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP (HSP90) Transferase Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase Serine/threonin kinase Lipoxygenase Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Fatty Acid Synthase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase DHFR IDO/TDO Hydroxylase PCSK9 OXPHOS ROR Acyltransferase
Related Products	Trolox Nicotinic Acid Sodium ascorbate Amprolium HCl Thiamine pyrophosphate hydrochloride Ergosterol Fursultiamine D-Pantothenate Sodium

Chemical Information, Storage & Stability

Molecular Weight	300.81	Formula	C₁₂H₁₇ClN₄OS	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	59-43-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Vitamin B1			Smiles	[Cl-].CC1=NC=C(C[N+]2=CSC(=C2C)CCO)C(=N1)N

Solubility

In vitro
Batch:

DMSO : 60 mg/mL ( (199.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 60 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	https://pubmed.ncbi.nlm.nih.gov/23696956/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06323538	Not yet recruiting	Dietary Exposure\|Diabetes Mellitus Type 2\|Cardiovascular Diseases\|Bone Loss\|Sustainability\|Exposure\|Obesity\|Vitamin Deficiency\|Mineral Deficiency	German Federal Institute for Risk Assessment\|Max Rubner-Institut\|University of Bonn\|Research Institute for Plant-Based Nutrition\|University of Jena\|University of Regensburg\|Heidelberg University\|University of Vienna	April 1 2024	--
NCT06057597	Recruiting	Obesity\|Morbid	Assistance Publique - Hôpitaux de Paris	November 13 2023	Not Applicable
NCT05474105	Recruiting	Ischemic Stroke	Barts & The London NHS Trust\|Queen Mary University of London\|Nutricia Research	July 11 2023	Not Applicable
NCT05742516	Recruiting	Exogenous Carbohydrate Oxidation	University of Bath\|Clasado Biosciences	April 23 2023	Not Applicable
NCT05610137	Completed	Dietary Intake	Vanessa Corrales Agudelo\|Vidarium Nutrition Health and Wellness Research Center	October 18 2022	--
NCT05382533	Completed	Decreased Cardovascular Risk\|Decreased Risk of Diabetes Mellitus Type II	University of Jena	May 30 2022	Not Applicable

Tech Support

Handling Instructions

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