Oleuropein

For research use only.

Catalog No.S7867

1 publication

Oleuropein Chemical Structure

CAS No. 32619-42-4

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.

Selleck's Oleuropein has been cited by 1 publication

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Biological Activity

Description Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.
In vitro

In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. [1] Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. [2] In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
rat IEC-18 cells NHzFTXVHfW6ldHnvckBie3OjeR?= M4q4RWlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgdFM5KE2DUFugdIhwe3Cqb4L5cIF1cW:wIHnuJJJifCCLRVOtNVgh[2WubIOgZZQhOTByIIXNJIlv[3WkYYTl[EBnd3JiMTDodkBxemmxcjD0c{BNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd3OEGxNEc,OjN5NUixNVA9N2F-

... Click to View More Cell Line Experimental Data

In vivo In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. [3] In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity. [4]

Protocol

Cell Research:

[3]

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  • Cell lines: TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells
  • Concentrations: --
  • Incubation Time: 5 days
  • Method:

    Approximately 5 × 103 cells (TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib) are seeded in triplicate wells of 96-well plates in 100 μl of their respective growth medium with increasing doses of purified Oleuropein. Cell proliferation is determined on day 5 using the CellTiter MTS cell proliferation kit according to the manufacturer’s instructions. Absorbance at 490 nm is measured with a Bio-Tek Instruments microplate reader. Background readings are subtracted from the experimental readings.


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: Swiss albino mice that spontaneously develops soft tissue sarcomas
  • Dosages: 50 μg/mouse
  • Administration: i.p. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (185.01 mM)
Water 100 mg/mL warmed (185.01 mM)
Ethanol 100 mg/mL warmed (185.01 mM)
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
PBS
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.51
Formula

C25H32O13

CAS No. 32619-42-4
Storage powder
in solvent
Synonyms N/A
Smiles CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID