Home Immunology & Inflammation Immunology & Inflammation related chemical Umbelliferone

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Umbelliferone Immunology & Inflammation related chemical

Cat.No.S3675

Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
Umbelliferone Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 162.14

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Quality Control

Batch: S367501 DMSO]32 mg/mL]false]Ethanol]32 mg/mL]false]Water]Insoluble]false Purity: 99.4%
99.4

Chemical Information, Storage & Stability

Molecular Weight 162.14 Formula

C9H6O3

 Storage (From the date of receipt)
CAS No. 93-35-6 Download SDF Storage of Stock Solutions

Synonyms 7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone Smiles C1=CC(=CC2=C1C=CC(=O)O2)O

Solubility

In vitro
Batch:

DMSO : 32 mg/mL ( (197.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble

Molarity Calculator

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In vivo
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Mechanism of Action

In vitro
Treatment of KB cells with Umbelliferone (UMB), prevents and reduces the cell proliferation with the IC50--200 μM as well as induces loss of cell viability, morphology change and internucleosomal DNA fragmentation in a concentration dependent manner. UMB induces apoptosis in KB cells in a dose dependent manner. UMB has the potential to increase oxidative DNA damage in KB cells through DNA tail formation significantly. UMB brings a dose-dependent elevation of reactive oxygen species (ROS), which is evidenced by the DCF fluorescence, alters the mitochondrial membrane potential in KB cells. UMB exhibits anticancer effect on KB cell line with the increased generation of intracellular ROS, triggers oxidative stress mediated depolarization of mitochondria, which contributes cell death via DNA damage as well as cell cycle arrest at G0/G1 phase. UMB protects alcoholic fatty liver, detoxify reactive aldehyde, radiation mediated cellular damage in human blood lymphocytes, immuno modulators and treat vascular lesions[1].
In vivo
Treatment with umbelliferone (60 and 90 mg/kg) causes a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation are observed in mice treated with umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-γ, is found in bronchoalveolar lavage fluids of mice treated with umbelliferone. umbelliferone attenuates airway inflammation in a murine model of asthma[2]. Dietary administration of umbelliferone and esculetin significantly attenuates MPTP-induced neurotoxicity in the substantia nigra pars compacta but not striatum, as measured by tyrosine hydroxylase staining. Umbelliferone also prevents MPTP-dependent caspase 3 activation, an indicator of apoptosis, but does not inhibit monoamine oxidase activity[3].
References

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