Demethyleneberberine

Catalog No.S3299 Synonyms: DMB

For research use only.

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.

Demethyleneberberine Chemical Structure

CAS No. 25459-91-0

Purity & Quality Control

Choose Selective Peroxidases Inhibitors

Biological Activity

Description Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
Targets
NF-κB [1]
()
MPO [1]
()
IL-6 [1]
()
TNF-α [1]
()
IL-1β [1]
()
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Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 3 mg/mL
(9.24 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 324.35
Formula

C19H18NO4

CAS No. 25459-91-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04785326 Active not recruiting Drug: DMB-3115|Drug: Stelara Moderate to Severe Chronic Plaque Psoriasis Dong-A ST Co. Ltd.|Meiji Seika Pharma Co. Ltd. April 28 2021 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

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