Home Immunology & Inflammation Peroxidases inhibitor - Interleukins inhibitor - TNF-alpha inhibitor - NF-κB inhibitor - AMPK activator Demethyleneberberine For research use only.

Demethyleneberberine

Synonyms: DMB

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.

Demethyleneberberine Chemical Structure

Demethyleneberberine Chemical Structure

CAS: 25459-91-0

Purity & Quality Control

Batch: S329901 DMSO] 3 mg/mL] false] ] ] false] ] ] false Purity: 99.01%
99.01

Demethyleneberberine Related Products

Choose Selective Peroxidases Inhibitors

Biological Activity

Description Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
Targets
NF-κB [1] MPO [1] IL-6 [1] TNF-α [1] IL-1β [1] Click to View More Targets
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04785326 Completed
Moderate to Severe Chronic Plaque Psoriasis
Dong-A ST Co. Ltd.|Meiji Seika Pharma Co. Ltd.
 April 28 2021 Phase 3

Chemical Information & Solubility

Molecular Weight 324.35 Formula

C19H18NO4
CAS No. 25459-91-0 SDF --
Smiles COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 3 mg/mL ( (9.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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