Demethyleneberberine

For research use only.

Catalog No.S3299 Synonyms: DMB

Demethyleneberberine Chemical Structure

CAS No. 25459-91-0

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.

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Biological Activity

Description Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
Targets
NF-κB [1]
()
MPO [1]
()
IL-6 [1]
()
TNF-α [1]
()
IL-1β [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 3 mg/mL (9.24 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 324.35
Formula

C19H18NO4

CAS No. 25459-91-0
Storage powder
in solvent
Synonyms DMB

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04785326 Recruiting Drug: DMB-3115|Drug: Stelara Moderate to Severe Chronic Plaque Psoriasis Dong-A ST Co. Ltd.|Meiji Seika Pharma Co. Ltd. April 28 2021 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID